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Article: Effects of ginseng on ethanol induced sedation in mice

TitleEffects of ginseng on ethanol induced sedation in mice
Authors
KeywordsEthanol
Ginseng
Righting reflex
Issue Date1998
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1998, v. 64 n. 2, p. 153-160 How to Cite?
AbstractThe effects of ginseng, ginsenosides, coffee, and caffeine on 75% ethanol induced sleeping in mice were examined. Mice treated with ethanol lost their fighting reflex within 30 min and this lasted for about 4 h. The onset time of lose of righting reflex (LR) in mice pre-treated with ginseng, ginsenosides, coffee or caffeine 10 min before ethanol was significantly delayed; whereas the duration of sleep was not affected by all treatments. Administration of these agents 10 min alter ethanol was ineffective in counteracting the LR effect of ethanol. Coffee and caffeine produced central stimulation and increased locomotor activity. Ginseng and ginsenosides were found to enhance exercise endurance and reduced the plasma level of ethanol. Gastric emptying was slowed by ginseng, ginsenosides or ethanol administration. An additive effect was observed when the mice were pre- treated with ginseng or ginsenosides 10 rain before ethanol administration. It is suggested that ginseng decreased plasma ethanol concentration by delaying gastric emptying and this may be partly due to the effect of the ginsenosides.
Persistent Identifierhttp://hdl.handle.net/10722/80295
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKoo, MWLen_HK
dc.date.accessioned2010-09-06T08:04:43Z-
dc.date.available2010-09-06T08:04:43Z-
dc.date.issued1998en_HK
dc.identifier.citationLife Sciences, 1998, v. 64 n. 2, p. 153-160en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80295-
dc.description.abstractThe effects of ginseng, ginsenosides, coffee, and caffeine on 75% ethanol induced sleeping in mice were examined. Mice treated with ethanol lost their fighting reflex within 30 min and this lasted for about 4 h. The onset time of lose of righting reflex (LR) in mice pre-treated with ginseng, ginsenosides, coffee or caffeine 10 min before ethanol was significantly delayed; whereas the duration of sleep was not affected by all treatments. Administration of these agents 10 min alter ethanol was ineffective in counteracting the LR effect of ethanol. Coffee and caffeine produced central stimulation and increased locomotor activity. Ginseng and ginsenosides were found to enhance exercise endurance and reduced the plasma level of ethanol. Gastric emptying was slowed by ginseng, ginsenosides or ethanol administration. An additive effect was observed when the mice were pre- treated with ginseng or ginsenosides 10 rain before ethanol administration. It is suggested that ginseng decreased plasma ethanol concentration by delaying gastric emptying and this may be partly due to the effect of the ginsenosides.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.rightsLife Sciences. Copyright © Elsevier Inc.en_HK
dc.subjectEthanolen_HK
dc.subjectGinsengen_HK
dc.subjectRighting reflexen_HK
dc.titleEffects of ginseng on ethanol induced sedation in miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0024-3205&volume=64&issue=2&spage=153&epage=160&date=1998&atitle=Effects+of+Ginseng+on+ethanol+induced+sedation+in+miceen_HK
dc.identifier.emailKoo, MWL: wlkoo@hku.hken_HK
dc.identifier.authorityKoo, MWL=rp00233en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0024-3205(98)00545-1en_HK
dc.identifier.pmid10069493-
dc.identifier.scopuseid_2-s2.0-0032484258en_HK
dc.identifier.hkuros45664en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032484258&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume64en_HK
dc.identifier.issue2en_HK
dc.identifier.spage153en_HK
dc.identifier.epage160en_HK
dc.identifier.isiWOS:000077566300007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKoo, MWL=7004550899en_HK

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