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Article: Folic acid supplementation modifies β-adrenoceptor-mediated in vitro lipolysis of obese/diabetic (+db/+db) mice

TitleFolic acid supplementation modifies β-adrenoceptor-mediated in vitro lipolysis of obese/diabetic (+db/+db) mice
Authors
Keywordsβ-adrenoceptor
+db/+db mice
Adipocytes
Folic acid
Lipolysis
Issue Date2009
PublisherSociety for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/
Citation
Experimental Biology And Medicine, 2009, v. 234 n. 9, p. 1047-1055 How to Cite?
AbstractThe effects of folic acid (5.7 and 71 lg/kg, 4 weeks) consumption on the β-adrenoceptors (β-ARs)-elicited lipolysis in vitro of the abdominal adipocytes of lean/control (+m/+db) and obese/diabetic (+db/+db) mice (female) were investigated. β-AR agonists (salbutamol, a β 2-AR agonist; BRL 37344 and CGP 12177, β 3-AR agonists; adrenaline, a β-AR agonist)-mediated lipolysis, β 2-, and β 3-ARs protein expression of the adipose tissues after folic acid consumption were evaluated. Our results demonstrate that a smaller magnitude of the basal (spontaneous) and the β-AR agonists-triggered lipolysis was observed in +db/+db mice, and folic acid supplementation (71 μg/kg) resulted in an improvement of both the baseline and the β-ARs-mediated lipolysis. In controls, a lower β 2- and β 3-ARs protein expression of the adipose tissues was detected in +db/+db mice, compared to +m/+db mice. In both strains fed with folic acid (71 μg/kg), a reduction of β 2-AR protein expression was observed compared to the respective controls. In +db/+db mice, folic acid (5.7 and 71 μg/kg) consumption caused a dose-dependent increase of β 3-AR protein expression compared to controls. We demonstrate that lipolysis elicited by β-AR (β 2- and β 3-ARs) agonists was blunted in +db/+db mice. Folic acid consumption has significant modulatory effects on β-ARs protein expression and lipolysis. Copyright © 2009 by the Society for Experimental Biology and Medicine.
Persistent Identifierhttp://hdl.handle.net/10722/80293
ISSN
2015 Impact Factor: 2.542
2015 SCImago Journal Rankings: 0.991
ISI Accession Number ID
Funding AgencyGrant Number
Chou's Foundation Fund
Student Campus Work Scheme (Shaw College, The Chinese University of Hong Kong
Funding Information:

Provision of the Student Campus Work Scheme by the Chou's Foundation Fund and the Student Campus Work Scheme (Shaw College, The Chinese University of Hong Kong) is appreciated. Proofreading of the manuscript by Mr. Ho Yeung Lain is acknowledged.

References

 

DC FieldValueLanguage
dc.contributor.authorTsz, YLen_HK
dc.contributor.authorSai, WSen_HK
dc.contributor.authorAu, ALSen_HK
dc.contributor.authorPoon, CCWen_HK
dc.contributor.authorLi, RWSen_HK
dc.contributor.authorHo, YLen_HK
dc.contributor.authorWing, SLen_HK
dc.contributor.authorShun, WCen_HK
dc.contributor.authorSai, MNen_HK
dc.contributor.authorLeung, GPHen_HK
dc.contributor.authorLee, SMYen_HK
dc.contributor.authorTsui, SKWen_HK
dc.contributor.authorYiu, WKen_HK
dc.date.accessioned2010-09-06T08:04:42Z-
dc.date.available2010-09-06T08:04:42Z-
dc.date.issued2009en_HK
dc.identifier.citationExperimental Biology And Medicine, 2009, v. 234 n. 9, p. 1047-1055en_HK
dc.identifier.issn1535-3702en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80293-
dc.description.abstractThe effects of folic acid (5.7 and 71 lg/kg, 4 weeks) consumption on the β-adrenoceptors (β-ARs)-elicited lipolysis in vitro of the abdominal adipocytes of lean/control (+m/+db) and obese/diabetic (+db/+db) mice (female) were investigated. β-AR agonists (salbutamol, a β 2-AR agonist; BRL 37344 and CGP 12177, β 3-AR agonists; adrenaline, a β-AR agonist)-mediated lipolysis, β 2-, and β 3-ARs protein expression of the adipose tissues after folic acid consumption were evaluated. Our results demonstrate that a smaller magnitude of the basal (spontaneous) and the β-AR agonists-triggered lipolysis was observed in +db/+db mice, and folic acid supplementation (71 μg/kg) resulted in an improvement of both the baseline and the β-ARs-mediated lipolysis. In controls, a lower β 2- and β 3-ARs protein expression of the adipose tissues was detected in +db/+db mice, compared to +m/+db mice. In both strains fed with folic acid (71 μg/kg), a reduction of β 2-AR protein expression was observed compared to the respective controls. In +db/+db mice, folic acid (5.7 and 71 μg/kg) consumption caused a dose-dependent increase of β 3-AR protein expression compared to controls. We demonstrate that lipolysis elicited by β-AR (β 2- and β 3-ARs) agonists was blunted in +db/+db mice. Folic acid consumption has significant modulatory effects on β-ARs protein expression and lipolysis. Copyright © 2009 by the Society for Experimental Biology and Medicine.en_HK
dc.languageengen_HK
dc.publisherSociety for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/en_HK
dc.relation.ispartofExperimental Biology and Medicineen_HK
dc.subjectβ-adrenoceptoren_HK
dc.subject+db/+db miceen_HK
dc.subjectAdipocytesen_HK
dc.subjectFolic aciden_HK
dc.subjectLipolysisen_HK
dc.titleFolic acid supplementation modifies β-adrenoceptor-mediated in vitro lipolysis of obese/diabetic (+db/+db) miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1535-3702&volume=234&issue=9&spage=1047&epage=1055&date=2009&atitle=Folic+acid+supplementation+modifies+beta-adrenoceptor-mediated+in+vitro+lipolysis+of+obese/diabetic+(+db/+db)+miceen_HK
dc.identifier.emailLeung, GPH: gphleung@hkucc.hku.hken_HK
dc.identifier.authorityLeung, GPH=rp00234en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3181/0902-RM-44en_HK
dc.identifier.pmid19596833-
dc.identifier.scopuseid_2-s2.0-70349094101en_HK
dc.identifier.hkuros165871en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349094101&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume234en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1047en_HK
dc.identifier.epage1055en_HK
dc.identifier.isiWOS:000269966600006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTsz, YL=35189588500en_HK
dc.identifier.scopusauthoridSai, WS=26538926000en_HK
dc.identifier.scopusauthoridAu, ALS=7005391144en_HK
dc.identifier.scopusauthoridPoon, CCW=26656895800en_HK
dc.identifier.scopusauthoridLi, RWS=7404722884en_HK
dc.identifier.scopusauthoridHo, YL=35188802000en_HK
dc.identifier.scopusauthoridWing, SL=35189672400en_HK
dc.identifier.scopusauthoridShun, WC=7404255670en_HK
dc.identifier.scopusauthoridSai, MN=22035995700en_HK
dc.identifier.scopusauthoridLeung, GPH=35963668200en_HK
dc.identifier.scopusauthoridLee, SMY=35233892600en_HK
dc.identifier.scopusauthoridTsui, SKW=7004961364en_HK
dc.identifier.scopusauthoridYiu, WK=9940937400en_HK

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