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Article: 5-Hydroxytryptamine and thromboxane A2 as physiologic mediators of human umbilical artery closure

Title5-Hydroxytryptamine and thromboxane A2 as physiologic mediators of human umbilical artery closure
Authors
Keywords5-hydroxytryptamine
Human umbilical arteries
Thromboxane A2
Umbilical cord closure
Vasoconstriction
Issue Date2003
PublisherSage Publications, Inc. The Journal's web site is located at http://rsx.sagepub.com
Citation
Journal Of The Society For Gynecologic Investigation, 2003, v. 10 n. 8, p. 490-495 How to Cite?
AbstractOBJECTIVE: This study investigated the response of the human umbilical artery to various agonists in order to determine which agents might be involved in umbilical cord closure. METHODS: Umbilical artery rings from 22 cesarean deliveries were suspended in tissue baths containing Krebs-Henseleit solution under low and normal oxygen conditions. Samples were challenged with 5-hydroxytryptamine, acetylcholine, angiotensin II, bradykinin, endothelin-1, histamine, norepinephrine, phenylephrine, and U46619 (a thromboxane A 2 mimetic). RESULTS: Only 5-hydroxytryptamine, bradykinin, endothelin-1, histamine, and U46619 produced appreciable maximal contractions. Furthermore, although the contractile force generated by these agonists was diminished in normal oxygen conditions, this reduction affected responses to 5-hydroxytryptamine and U46619 least. CONCLUSION: 5-Hydroxytryptamine and U46619 demonstrated the characteristics most likely to be associated with closure of the umbilical artery, ie, they elicited strong, sustained contractions at physiologic concentrations and under both normal and low-oxygen conditions. These data suggest that closure of the umbilical artery may be mediated by 5-hydroxytryptamine and thromboxane A2. Copyright © 2003 by the Society for Gynecologic Investigation.
Persistent Identifierhttp://hdl.handle.net/10722/80290
ISSN
2008 Impact Factor: 2.333
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQuan, Aen_HK
dc.contributor.authorLeung, SWSen_HK
dc.contributor.authorLao, TTen_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2010-09-06T08:04:40Z-
dc.date.available2010-09-06T08:04:40Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of The Society For Gynecologic Investigation, 2003, v. 10 n. 8, p. 490-495en_HK
dc.identifier.issn1071-5576en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80290-
dc.description.abstractOBJECTIVE: This study investigated the response of the human umbilical artery to various agonists in order to determine which agents might be involved in umbilical cord closure. METHODS: Umbilical artery rings from 22 cesarean deliveries were suspended in tissue baths containing Krebs-Henseleit solution under low and normal oxygen conditions. Samples were challenged with 5-hydroxytryptamine, acetylcholine, angiotensin II, bradykinin, endothelin-1, histamine, norepinephrine, phenylephrine, and U46619 (a thromboxane A 2 mimetic). RESULTS: Only 5-hydroxytryptamine, bradykinin, endothelin-1, histamine, and U46619 produced appreciable maximal contractions. Furthermore, although the contractile force generated by these agonists was diminished in normal oxygen conditions, this reduction affected responses to 5-hydroxytryptamine and U46619 least. CONCLUSION: 5-Hydroxytryptamine and U46619 demonstrated the characteristics most likely to be associated with closure of the umbilical artery, ie, they elicited strong, sustained contractions at physiologic concentrations and under both normal and low-oxygen conditions. These data suggest that closure of the umbilical artery may be mediated by 5-hydroxytryptamine and thromboxane A2. Copyright © 2003 by the Society for Gynecologic Investigation.en_HK
dc.languageengen_HK
dc.publisherSage Publications, Inc. The Journal's web site is located at http://rsx.sagepub.comen_HK
dc.relation.ispartofJournal of the Society for Gynecologic Investigationen_HK
dc.rightsJournal of the Society for Gynecologic Investigation. Copyright © Sage Publications, Inc.en_HK
dc.subject5-hydroxytryptamineen_HK
dc.subjectHuman umbilical arteriesen_HK
dc.subjectThromboxane A2en_HK
dc.subjectUmbilical cord closureen_HK
dc.subjectVasoconstrictionen_HK
dc.title5-Hydroxytryptamine and thromboxane A2 as physiologic mediators of human umbilical artery closureen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1071-5576&volume=10&issue=8&spage=490&epage=495&date=2003&atitle=5-Hydroxytryptamine+and+Thromboxane+A2+as+Physiologic+Mediators+of+Human+Umbilical+Artery+Closureen_HK
dc.identifier.emailLeung, SWS: swsleung@hku.hken_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SWS=rp00235en_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1071-5576(03)00149-7en_HK
dc.identifier.pmid14662162-
dc.identifier.scopuseid_2-s2.0-0345528877en_HK
dc.identifier.hkuros85973en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0345528877&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue8en_HK
dc.identifier.spage490en_HK
dc.identifier.epage495en_HK
dc.identifier.isiWOS:000187209100007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridQuan, A=7006871453en_HK
dc.identifier.scopusauthoridLeung, SWS=24540419500en_HK
dc.identifier.scopusauthoridLao, TT=35275381600en_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK

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