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Article: Over-expression of inducible heat shock protein 70 in the gastric mucosa of partially sleep-deprived rats

TitleOver-expression of inducible heat shock protein 70 in the gastric mucosa of partially sleep-deprived rats
Authors
KeywordsAcid-induced gastric damage
Gastric acidity
Gastrin
Inducible heat shock protein 70
Partial sleep deprivation
Issue Date2004
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00365521.asp
Citation
Scandinavian Journal Of Gastroenterology, 2004, v. 39 n. 6, p. 510-515 How to Cite?
AbstractBackground: Previous findings have demonstrated increased expression of inducible heat shock protein 70 (iHSP70) in the gastric mucosa of rats exposed to partial sleep deprived (PSD). The purpose of this study was to investigate the functional role of iHSP70 and its relationship with acid secretion in the stomachs of PSD animals. Methods: A slowly rotating drum was used to induce PSD in male Sprague-Dawley rats with or without omeprazole treatment. Gastric mucosal samples were harvested for iHSP70 mRNA and protein analysis with RT-PCR and Western blotting, respectively. Enzyme immunoassay was used to determine plasma gastrin level and gastric acidity was measured by titration. The modulating effect of PSD on 0.6 M hydrochloric acid (HCl)-induced gastric damage was also evaluated. Results: PSD increased plasma gastrin, gastric acidity and expression of iHSP70, while significantly reducing HCl-induced gastric damage. Omeprazole administration decreased gastric acidity and reversed iHSP70 over-expression in PSD rats. Conclusions: PSD increases gastric acidity which enhances expression of mucosal iHSP70. Over-expression of iHSP70 may be a protective homeostatic response of the stomach to stress induced by PSD and acid secretion.
Persistent Identifierhttp://hdl.handle.net/10722/80287
ISSN
2015 Impact Factor: 2.199
2015 SCImago Journal Rankings: 0.891
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuo, JSen_HK
dc.contributor.authorChau, JFLen_HK
dc.contributor.authorShen, XZen_HK
dc.contributor.authorCho, CHen_HK
dc.contributor.authorLuk, JMen_HK
dc.contributor.authorKoo, MWLen_HK
dc.date.accessioned2010-09-06T08:04:38Z-
dc.date.available2010-09-06T08:04:38Z-
dc.date.issued2004en_HK
dc.identifier.citationScandinavian Journal Of Gastroenterology, 2004, v. 39 n. 6, p. 510-515en_HK
dc.identifier.issn0036-5521en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80287-
dc.description.abstractBackground: Previous findings have demonstrated increased expression of inducible heat shock protein 70 (iHSP70) in the gastric mucosa of rats exposed to partial sleep deprived (PSD). The purpose of this study was to investigate the functional role of iHSP70 and its relationship with acid secretion in the stomachs of PSD animals. Methods: A slowly rotating drum was used to induce PSD in male Sprague-Dawley rats with or without omeprazole treatment. Gastric mucosal samples were harvested for iHSP70 mRNA and protein analysis with RT-PCR and Western blotting, respectively. Enzyme immunoassay was used to determine plasma gastrin level and gastric acidity was measured by titration. The modulating effect of PSD on 0.6 M hydrochloric acid (HCl)-induced gastric damage was also evaluated. Results: PSD increased plasma gastrin, gastric acidity and expression of iHSP70, while significantly reducing HCl-induced gastric damage. Omeprazole administration decreased gastric acidity and reversed iHSP70 over-expression in PSD rats. Conclusions: PSD increases gastric acidity which enhances expression of mucosal iHSP70. Over-expression of iHSP70 may be a protective homeostatic response of the stomach to stress induced by PSD and acid secretion.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00365521.aspen_HK
dc.relation.ispartofScandinavian Journal of Gastroenterologyen_HK
dc.rightsScandinavian Journal of Gastroenterology. Copyright © Informa Healthcare.en_HK
dc.subjectAcid-induced gastric damageen_HK
dc.subjectGastric acidityen_HK
dc.subjectGastrinen_HK
dc.subjectInducible heat shock protein 70en_HK
dc.subjectPartial sleep deprivationen_HK
dc.titleOver-expression of inducible heat shock protein 70 in the gastric mucosa of partially sleep-deprived ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0036-5521&volume=39&spage=510&epage=515&date=2004&atitle=Over-Expression+of+Inducible+Heat+Shock+Protein+70+in+the+Gastric+Mucosa+of+Partially+Sleep-Deprived+Ratsen_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.emailKoo, MWL: wlkoo@hku.hken_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.identifier.authorityKoo, MWL=rp00233en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/00365520410004523en_HK
dc.identifier.pmid15223672-
dc.identifier.scopuseid_2-s2.0-3142708191en_HK
dc.identifier.hkuros88712en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3142708191&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue6en_HK
dc.identifier.spage510en_HK
dc.identifier.epage515en_HK
dc.identifier.isiWOS:000222222200002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridGuo, JS=7404488815en_HK
dc.identifier.scopusauthoridChau, JFL=9236841800en_HK
dc.identifier.scopusauthoridShen, XZ=7402721067en_HK
dc.identifier.scopusauthoridCho, CH=7403100461en_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK
dc.identifier.scopusauthoridKoo, MWL=7004550899en_HK

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