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Article: Effects of Centella asiatica on ethanol induced gastric mucosal lesions in rats

TitleEffects of Centella asiatica on ethanol induced gastric mucosal lesions in rats
Authors
Cheng, CLKoo, MWL
KeywordsCentella asiatica
Gastric mucosal lesions
MPO activity
Transmucosal potential difference
Issue Date2000
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 2000, v. 67 n. 21, p. 2647-2653 How to Cite?
DOI: http://dx.doi.org/10.1016/S0024-3205(00)00848-1
AbstractCentella asiatica is a herbal medicine widely used in China and India for wound healing. The aim of this study was to examine its effects on the prevention of ethanol induced gastric lesions in rats. Gastric transmucosal potential difference (PD) was reduced by the application of 50% ethanol in the gastric ex-vivo chamber model and Centella extract (CE) accelerated its recovery. Oral administration of CE (0.05g/kg, 0.25g/kg and 0.50g/kg) before ethanol administration significantly inhibited gastric lesions formation (58% to 82% reduction) and decreased mucosal myeloperoxidase (MPO) activity in a dose dependent manner. These results suggested that CE prevented ethanol induced gastric mucosal lesions by strengthening the mucosal barrier and reducing the damaging effects of free radicals. (C) 2000 Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/80286
ISSN
0024-3205
2023 Impact Factor: 5.2
2023 SCImago Journal Rankings: 1.257
ISI Accession Number ID
WOS:000089928900011
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorCheng, CLen_HK
dc.contributor.authorKoo, MWLen_HK
dc.date.accessioned2010-09-06T08:04:37Z-
dc.date.available2010-09-06T08:04:37Z-
dc.date.issued2000en_HK
dc.identifier.citationLife Sciences, 2000, v. 67 n. 21, p. 2647-2653en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80286-
dc.description.abstractCentella asiatica is a herbal medicine widely used in China and India for wound healing. The aim of this study was to examine its effects on the prevention of ethanol induced gastric lesions in rats. Gastric transmucosal potential difference (PD) was reduced by the application of 50% ethanol in the gastric ex-vivo chamber model and Centella extract (CE) accelerated its recovery. Oral administration of CE (0.05g/kg, 0.25g/kg and 0.50g/kg) before ethanol administration significantly inhibited gastric lesions formation (58% to 82% reduction) and decreased mucosal myeloperoxidase (MPO) activity in a dose dependent manner. These results suggested that CE prevented ethanol induced gastric mucosal lesions by strengthening the mucosal barrier and reducing the damaging effects of free radicals. (C) 2000 Elsevier Science Inc.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.rightsLife Sciences. Copyright © Elsevier Inc.en_HK
dc.subjectCentella asiaticaen_HK
dc.subjectGastric mucosal lesionsen_HK
dc.subjectMPO activityen_HK
dc.subjectTransmucosal potential differenceen_HK
dc.titleEffects of Centella asiatica on ethanol induced gastric mucosal lesions in ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0024-3205&volume=67&spage=2647&epage=2653&date=2000&atitle=Effects+of+Centella+asiatica+on+ethanol+induced+gastric+mucosal+lesions+in+ratsen_HK
dc.identifier.emailKoo, MWL: wlkoo@hku.hken_HK
dc.identifier.authorityKoo, MWL=rp00233en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0024-3205(00)00848-1-
dc.identifier.pmid11104366-
dc.identifier.scopuseid_2-s2.0-0034644721en_HK
dc.identifier.hkuros58807en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034644721&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume67en_HK
dc.identifier.issue21en_HK
dc.identifier.spage2647en_HK
dc.identifier.epage2653en_HK
dc.identifier.isiWOS:000089928900011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheng, CL=7404797794en_HK
dc.identifier.scopusauthoridKoo, MWL=7004550899en_HK
dc.identifier.issnl0024-3205-

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