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Article: Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-α, and C-reactive protein to a high-fat dietary load

TitlePostprandial response of adiponectin, interleukin-6, tumor necrosis factor-α, and C-reactive protein to a high-fat dietary load
Authors
KeywordsAdiponectin
Inflammatory cytokines
Postprandial
Saturated fatty acids
Issue Date2008
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nut
Citation
Nutrition, 2008, v. 24 n. 4, p. 322-329 How to Cite?
AbstractObjective: Circulating levels of adiponectin are low in obesity and metabolic disorders associated with increasing fat mass including insulin resistance and dyslipidemia. Body fat stores may be positively related to intake of dietary fat, but little is known of mechanisms by which serum adiponectin may be regulated through diet. We investigated acute effects of a high-fat load and changes in fatty acid saturation on circulating adiponectin and associated mediators of inflammation including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP). Methods: A high-fat test meal (59 ± 4 g fat; 71% of energy as fat) containing a high (∼71:29) or low (∼55:45) ratio of saturated:unsaturated fatty acids was given at breakfast on two occasions. Blood samples were collected at 0 (baseline), 1, 3, and 6 h for measurement of adiponectin, IL-6, TNF-α, and high-sensitivity CRP. A fat-exclusion lunch, snack, and dinner were also given and blood samples collected at 10 and 24 h. Results: Eighteen healthy, lean men completed the trial. There was no evidence of acute change in circulating adiponectin in response to the lipid bolus or a differential effect of fatty acid saturation on adiponectin, high-sensitivity CRP, or IL-6 (P > 0.05). IL-6 increased over 6 h on both treatments (time, P < 0.05). TNF-α decreased on the high saturated:unsaturated fatty acid treatment (treatment by time, P < 0.05). There were no significant correlations between circulating adiponectin and insulin on either dietary treatment in these normoglycemic subjects. Conclusion: Acute changes in the content of saturated and unsaturated fatty acids had no adverse effect on postprandial circulation of the adipose-related factors adiponectin, IL-6, TNF-α, or high-sensitivity CRP. © 2008 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/80281
ISSN
2015 Impact Factor: 2.839
2015 SCImago Journal Rankings: 1.085
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPoppitt, SDen_HK
dc.contributor.authorKeogh, GFen_HK
dc.contributor.authorLithander, FEen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorMulvey, TBen_HK
dc.contributor.authorChan, YKen_HK
dc.contributor.authorMcArdle, BHen_HK
dc.contributor.authorCooper, GJSen_HK
dc.date.accessioned2010-09-06T08:04:34Z-
dc.date.available2010-09-06T08:04:34Z-
dc.date.issued2008en_HK
dc.identifier.citationNutrition, 2008, v. 24 n. 4, p. 322-329en_HK
dc.identifier.issn0899-9007en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80281-
dc.description.abstractObjective: Circulating levels of adiponectin are low in obesity and metabolic disorders associated with increasing fat mass including insulin resistance and dyslipidemia. Body fat stores may be positively related to intake of dietary fat, but little is known of mechanisms by which serum adiponectin may be regulated through diet. We investigated acute effects of a high-fat load and changes in fatty acid saturation on circulating adiponectin and associated mediators of inflammation including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP). Methods: A high-fat test meal (59 ± 4 g fat; 71% of energy as fat) containing a high (∼71:29) or low (∼55:45) ratio of saturated:unsaturated fatty acids was given at breakfast on two occasions. Blood samples were collected at 0 (baseline), 1, 3, and 6 h for measurement of adiponectin, IL-6, TNF-α, and high-sensitivity CRP. A fat-exclusion lunch, snack, and dinner were also given and blood samples collected at 10 and 24 h. Results: Eighteen healthy, lean men completed the trial. There was no evidence of acute change in circulating adiponectin in response to the lipid bolus or a differential effect of fatty acid saturation on adiponectin, high-sensitivity CRP, or IL-6 (P > 0.05). IL-6 increased over 6 h on both treatments (time, P < 0.05). TNF-α decreased on the high saturated:unsaturated fatty acid treatment (treatment by time, P < 0.05). There were no significant correlations between circulating adiponectin and insulin on either dietary treatment in these normoglycemic subjects. Conclusion: Acute changes in the content of saturated and unsaturated fatty acids had no adverse effect on postprandial circulation of the adipose-related factors adiponectin, IL-6, TNF-α, or high-sensitivity CRP. © 2008 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nuten_HK
dc.relation.ispartofNutritionen_HK
dc.rightsNutrition. Copyright © Elsevier Inc.en_HK
dc.subjectAdiponectinen_HK
dc.subjectInflammatory cytokinesen_HK
dc.subjectPostprandialen_HK
dc.subjectSaturated fatty acidsen_HK
dc.titlePostprandial response of adiponectin, interleukin-6, tumor necrosis factor-α, and C-reactive protein to a high-fat dietary loaden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0899-9007&volume=24&spage=322&epage=9&date=2008&atitle=Postprandial+response+of+adiponectin,+interleukin-6,+tumor+necrosis+factor-alpha,+and+C-reactive+protein+to+a+high-fat+dietary+load.en_HK
dc.identifier.emailWang, Y: yuwanghk@hku.hken_HK
dc.identifier.authorityWang, Y=rp00239en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.nut.2007.12.012en_HK
dc.identifier.pmid18262390-
dc.identifier.scopuseid_2-s2.0-39949084669en_HK
dc.identifier.hkuros146082en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-39949084669&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue4en_HK
dc.identifier.spage322en_HK
dc.identifier.epage329en_HK
dc.identifier.isiWOS:000254231500005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPoppitt, SD=7004592052en_HK
dc.identifier.scopusauthoridKeogh, GF=7004386410en_HK
dc.identifier.scopusauthoridLithander, FE=23489547400en_HK
dc.identifier.scopusauthoridWang, Y=34973733700en_HK
dc.identifier.scopusauthoridMulvey, TB=7003519653en_HK
dc.identifier.scopusauthoridChan, YK=8613931200en_HK
dc.identifier.scopusauthoridMcArdle, BH=7005760191en_HK
dc.identifier.scopusauthoridCooper, GJS=7402355946en_HK

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