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Article: The effect of fenofibrate treatment on endothelium-dependent relaxation induced by oxidative modified low density lipoprotein from hyperlipidemic patients

TitleThe effect of fenofibrate treatment on endothelium-dependent relaxation induced by oxidative modified low density lipoprotein from hyperlipidemic patients
Authors
KeywordsFenofibrate
Hyperlipidemia
Low density lipoprotein
Lysophosphatidylcholine
Issue Date2000
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177
Citation
Molecular And Cellular Biochemistry, 2000, v. 207 n. 1-2, p. 123-129 How to Cite?
AbstractThe objective of the research project was to investigate whether fenofibrate treatment may alter the biochemical content of the oxidized LDL and consequently its ability to impair the endothelium-dependent relaxation in hyperlipidemic patients. We hypothesized that fenofibrate treatment of hyperlipidemic patients may attenuate the ability of their oxidized LDL to impair the endothelium-dependent relaxation of the blood vessels as a consequence of fenofibrate-induced changes to the content and composition of lysoPC in the LDL molecule. Hyperlipidemic patients (Type IIb and Type IV) were recruited from the Lipid Clinic, HSC, Winnipeg, Canada, for this study. A blood sample was taken immediately after the recruitment, a second sample was taken after 6 weeks of dietary treatment, and a third sample was taken after 8 weeks of fenofibrate treatment. LDL was isolated from the plasma and oxidized by copper sulfate. Fenofibrate was shown to be highly effect in the reduction of total cholesterol, LDL cholesterol and triglycerides in these patients. Fenofibrate treatment also caused the attenuation of impairment of endothelium-dependent relaxation by the oxidized LDL from these patients. A slight reduction of lysophosphatidylcholine level was also found in the oxidized LDL of the fenofibrate treated patients, relative to LDL isolated after dietary treatment. In addition there were no changes in the fatty acid levels of the lysophosphatidylcholine isolated from LDL. Taken together, our results suggest that while the reduced lysophosphatidylcholine levels may contribute to the attenuated impairment of the endothelium-dependent relaxation of the aortic ring, other unidentified factors impacted by fenofibrate are likely to contribute to the attenuated effects.
Persistent Identifierhttp://hdl.handle.net/10722/80254
ISSN
2015 Impact Factor: 2.613
2015 SCImago Journal Rankings: 1.019
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiang, Ben_HK
dc.contributor.authorMcMaster, JCen_HK
dc.contributor.authorKroeger, EAen_HK
dc.contributor.authorHatch, GMen_HK
dc.contributor.authorMymin, Den_HK
dc.contributor.authorDembinski, Ten_HK
dc.contributor.authorArthur, Gen_HK
dc.contributor.authorShen, Gen_HK
dc.contributor.authorMan, RYKen_HK
dc.contributor.authorChoy, PCen_HK
dc.date.accessioned2010-09-06T08:04:15Z-
dc.date.available2010-09-06T08:04:15Z-
dc.date.issued2000en_HK
dc.identifier.citationMolecular And Cellular Biochemistry, 2000, v. 207 n. 1-2, p. 123-129en_HK
dc.identifier.issn0300-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80254-
dc.description.abstractThe objective of the research project was to investigate whether fenofibrate treatment may alter the biochemical content of the oxidized LDL and consequently its ability to impair the endothelium-dependent relaxation in hyperlipidemic patients. We hypothesized that fenofibrate treatment of hyperlipidemic patients may attenuate the ability of their oxidized LDL to impair the endothelium-dependent relaxation of the blood vessels as a consequence of fenofibrate-induced changes to the content and composition of lysoPC in the LDL molecule. Hyperlipidemic patients (Type IIb and Type IV) were recruited from the Lipid Clinic, HSC, Winnipeg, Canada, for this study. A blood sample was taken immediately after the recruitment, a second sample was taken after 6 weeks of dietary treatment, and a third sample was taken after 8 weeks of fenofibrate treatment. LDL was isolated from the plasma and oxidized by copper sulfate. Fenofibrate was shown to be highly effect in the reduction of total cholesterol, LDL cholesterol and triglycerides in these patients. Fenofibrate treatment also caused the attenuation of impairment of endothelium-dependent relaxation by the oxidized LDL from these patients. A slight reduction of lysophosphatidylcholine level was also found in the oxidized LDL of the fenofibrate treated patients, relative to LDL isolated after dietary treatment. In addition there were no changes in the fatty acid levels of the lysophosphatidylcholine isolated from LDL. Taken together, our results suggest that while the reduced lysophosphatidylcholine levels may contribute to the attenuated impairment of the endothelium-dependent relaxation of the aortic ring, other unidentified factors impacted by fenofibrate are likely to contribute to the attenuated effects.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177en_HK
dc.relation.ispartofMolecular and Cellular Biochemistryen_HK
dc.subjectFenofibrateen_HK
dc.subjectHyperlipidemiaen_HK
dc.subjectLow density lipoproteinen_HK
dc.subjectLysophosphatidylcholineen_HK
dc.titleThe effect of fenofibrate treatment on endothelium-dependent relaxation induced by oxidative modified low density lipoprotein from hyperlipidemic patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-8177&volume=207&spage=123&epage=129&date=2000&atitle=The+effect+of+fenofibrate+treatment+on+endothelium-dependent+relaxation+induced+by+oxidative+modified+low+density+lipoprotein+from+hyperlipidemic+patientsen_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10888237-
dc.identifier.scopuseid_2-s2.0-18844465975en_HK
dc.identifier.hkuros58379en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18844465975&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume207en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage123en_HK
dc.identifier.epage129en_HK
dc.identifier.isiWOS:000087113200019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiang, B=7202071094en_HK
dc.identifier.scopusauthoridMcMaster, JC=7006833856en_HK
dc.identifier.scopusauthoridKroeger, EA=7003400023en_HK
dc.identifier.scopusauthoridHatch, GM=7102271713en_HK
dc.identifier.scopusauthoridMymin, D=6701628222en_HK
dc.identifier.scopusauthoridDembinski, T=6602725224en_HK
dc.identifier.scopusauthoridArthur, G=7102560612en_HK
dc.identifier.scopusauthoridShen, G=7401966876en_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK
dc.identifier.scopusauthoridChoy, PC=7006633002en_HK

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