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Article: Inhibitory effect of Chinese green tea on endothelial cell-induced LDL oxidation

TitleInhibitory effect of Chinese green tea on endothelial cell-induced LDL oxidation
Authors
KeywordsChinese green tea
Cholesterol
LDL oxidation
Lung Chen Tea
Relative electrophoretic mobility
TBARS
Issue Date2000
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis
Citation
Atherosclerosis, 2000, v. 148 n. 1, p. 67-73 How to Cite?
AbstractGreen tea has been shown to inhibit Cu2+-induced LDL oxidation and suppress lipoxygenase activity. Since LDL oxidation is a characteristic feature of atherogenesis and lipoxygenase is involved in the disease process, the effect of Lung Chen Tea, a non-fermented Chinese green tea, on LDL oxidation induced by human umbilical cord vascular endothelial cell was investigated in the present study. Lung Chen Tea was extracted with methanol and the dried powder was redissolved in water before extraction with chloroform and then ethyl acetate. Lung Chen Tea, chloroform and ethyl acetate fractions dose-dependently reduced LDL oxidation and decreased its relative electrophoretic mobility (P<0.001) when compared to the oxidized LDL. The lipid peroxidation products, thiobarbituric acid reactive substances, and cellular cholesterol were also significantly lowered by 5 and 10 μg/ml Lung Chen Tea (P<0.001) in a dose-dependent manner. The remaining aqueous layer, which was devoid of catechins after chloroform and ethyl acetate extractions, did not prevent LDL oxidation. The results of this study demonstrated that Lung Chen Tea and catechin-rich fractions significantly prevented endothelial cell induced LDL oxidation. The consumption of Lung Chen Tea may therefore lower the risk of coronary heart diseases. Copyright (C) 2000 Elsevier Science Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/80251
ISSN
2015 Impact Factor: 3.942
2015 SCImago Journal Rankings: 1.819
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, TTCen_HK
dc.contributor.authorKoo, MWLen_HK
dc.date.accessioned2010-09-06T08:04:13Z-
dc.date.available2010-09-06T08:04:13Z-
dc.date.issued2000en_HK
dc.identifier.citationAtherosclerosis, 2000, v. 148 n. 1, p. 67-73en_HK
dc.identifier.issn0021-9150en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80251-
dc.description.abstractGreen tea has been shown to inhibit Cu2+-induced LDL oxidation and suppress lipoxygenase activity. Since LDL oxidation is a characteristic feature of atherogenesis and lipoxygenase is involved in the disease process, the effect of Lung Chen Tea, a non-fermented Chinese green tea, on LDL oxidation induced by human umbilical cord vascular endothelial cell was investigated in the present study. Lung Chen Tea was extracted with methanol and the dried powder was redissolved in water before extraction with chloroform and then ethyl acetate. Lung Chen Tea, chloroform and ethyl acetate fractions dose-dependently reduced LDL oxidation and decreased its relative electrophoretic mobility (P<0.001) when compared to the oxidized LDL. The lipid peroxidation products, thiobarbituric acid reactive substances, and cellular cholesterol were also significantly lowered by 5 and 10 μg/ml Lung Chen Tea (P<0.001) in a dose-dependent manner. The remaining aqueous layer, which was devoid of catechins after chloroform and ethyl acetate extractions, did not prevent LDL oxidation. The results of this study demonstrated that Lung Chen Tea and catechin-rich fractions significantly prevented endothelial cell induced LDL oxidation. The consumption of Lung Chen Tea may therefore lower the risk of coronary heart diseases. Copyright (C) 2000 Elsevier Science Ireland Ltd.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosisen_HK
dc.relation.ispartofAtherosclerosisen_HK
dc.rightsAtherosclerosis. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectChinese green teaen_HK
dc.subjectCholesterolen_HK
dc.subjectLDL oxidationen_HK
dc.subjectLung Chen Teaen_HK
dc.subjectRelative electrophoretic mobilityen_HK
dc.subjectTBARSen_HK
dc.titleInhibitory effect of Chinese green tea on endothelial cell-induced LDL oxidationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9150&volume=148&spage=67&epage=73&date=2000&atitle=Inhibitory+effect+of+Chinese+green+tea+on+endothelial+cell-induced+LDL+oxidationen_HK
dc.identifier.emailKoo, MWL: wlkoo@hku.hken_HK
dc.identifier.authorityKoo, MWL=rp00233en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0021-9150(99)00239-7en_HK
dc.identifier.pmid10580172-
dc.identifier.scopuseid_2-s2.0-0033991717en_HK
dc.identifier.hkuros50139en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033991717&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume148en_HK
dc.identifier.issue1en_HK
dc.identifier.spage67en_HK
dc.identifier.epage73en_HK
dc.identifier.isiWOS:000084243200008-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridYang, TTC=8075284700en_HK
dc.identifier.scopusauthoridKoo, MWL=7004550899en_HK

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