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Article: Pathogenesis of nicotine treatment and its withdrawal on stress-induced gastric ulceration in rats

TitlePathogenesis of nicotine treatment and its withdrawal on stress-induced gastric ulceration in rats
Authors
KeywordsBlood flow
Gastric ulcer
Glutathione
Mucus
Nicotine
Prostaglandin E2
Issue Date2002
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 2002, v. 434 n. 1-2, p. 81-86 How to Cite?
AbstractPrevious studies showed that cigarette smoking was closely associated with gastric ulceration. People usually smoke under stress conditions, and together, these could induce more gastric damage. In the present study, we aimed to study the effects of nicotine administration and its withdrawal on stress-induced gastric ulceration in rats. Male Sprague-Dawley rats were given nicotine (25 or 50 μg/ml) for 10 days and then withdrawn for 2, 4 or 6 days. They were subjected to cold-restraint stress for 2 h after nicotine treatment or after nicotine withdrawal, and then killed. The results indicated that both nicotine treatment and its withdrawal potentiated stress-induced gastric damage. The mucosal glutathione (GSH) and mucus levels were reduced by stress and decreased further by nicotine. The prostaglandin E2 concentration remained unchanged. To conclude, the adverse effect of nicotine on stress ulceration was prostaglandin E2-independent but mediated by the depression of glutathione and mucus levels in the gastric mucosa. © 2002 Elsevier Science B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/80248
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, Den_HK
dc.contributor.authorKoo, MWLen_HK
dc.contributor.authorShin, VYen_HK
dc.contributor.authorLiu, ESLen_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2010-09-06T08:04:11Z-
dc.date.available2010-09-06T08:04:11Z-
dc.date.issued2002en_HK
dc.identifier.citationEuropean Journal Of Pharmacology, 2002, v. 434 n. 1-2, p. 81-86en_HK
dc.identifier.issn0014-2999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80248-
dc.description.abstractPrevious studies showed that cigarette smoking was closely associated with gastric ulceration. People usually smoke under stress conditions, and together, these could induce more gastric damage. In the present study, we aimed to study the effects of nicotine administration and its withdrawal on stress-induced gastric ulceration in rats. Male Sprague-Dawley rats were given nicotine (25 or 50 μg/ml) for 10 days and then withdrawn for 2, 4 or 6 days. They were subjected to cold-restraint stress for 2 h after nicotine treatment or after nicotine withdrawal, and then killed. The results indicated that both nicotine treatment and its withdrawal potentiated stress-induced gastric damage. The mucosal glutathione (GSH) and mucus levels were reduced by stress and decreased further by nicotine. The prostaglandin E2 concentration remained unchanged. To conclude, the adverse effect of nicotine on stress ulceration was prostaglandin E2-independent but mediated by the depression of glutathione and mucus levels in the gastric mucosa. © 2002 Elsevier Science B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_HK
dc.relation.ispartofEuropean Journal of Pharmacologyen_HK
dc.rightsEuropean Journal of Pharmacology. Copyright © Elsevier BV.en_HK
dc.subjectBlood flowen_HK
dc.subjectGastric ulceren_HK
dc.subjectGlutathioneen_HK
dc.subjectMucusen_HK
dc.subjectNicotineen_HK
dc.subjectProstaglandin E2en_HK
dc.titlePathogenesis of nicotine treatment and its withdrawal on stress-induced gastric ulceration in ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-2999&volume=434&spage=81&epage=86&date=2002&atitle=Pathogenesis+of+nicotine+treatment+and+its+withdrawal+on+stress-induced+gastric+ulceration+in+ratsen_HK
dc.identifier.emailKoo, MWL: wlkoo@hku.hken_HK
dc.identifier.authorityKoo, MWL=rp00233en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0014-2999(01)01529-1en_HK
dc.identifier.pmid11755169-
dc.identifier.scopuseid_2-s2.0-0037005736en_HK
dc.identifier.hkuros73404en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037005736&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume434en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage81en_HK
dc.identifier.epage86en_HK
dc.identifier.isiWOS:000173119400012-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridWong, D=36932587600en_HK
dc.identifier.scopusauthoridKoo, MWL=7004550899en_HK
dc.identifier.scopusauthoridShin, VY=7003491170en_HK
dc.identifier.scopusauthoridLiu, ESL=7202240071en_HK
dc.identifier.scopusauthoridCho, CH=7403100461en_HK

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