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Article: Angelica sinensis modulates migration and proliferation of gastric epithelial cells

TitleAngelica sinensis modulates migration and proliferation of gastric epithelial cells
Authors
KeywordsAngelica sinensis
Gastric epithelial cells
Migration
Proliferation
Issue Date2001
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 2001, v. 68 n. 8, p. 961-968 How to Cite?
AbstractA crude extract from Angelica sinensis (ASCE), which mainly consists of polysaccharides, prevents ethanol- or indomethacin-induced gastric mucosal damage and promotes ulcer healing. The aim of this study was to test the hypothesis that ASCE has a direct stimulating effect on gastric epithelial cells for wound healing. We found that ASCE significantly promoted the migration of epithelial cells over an artificial wound on the surface of an RGM-1 monolayer. The extract also stimulated DNA synthesis in a dose-dependent manner and concomitantly increased EGF mRNA expression. Co-incubation of ASCE with anti-EGF antibody reduced the speed of migration and the DNA synthesis, which however were still higher than the control without ASCE. These results strongly suggest that ASCE has a direct wound healing effect on gastric mucosa, and this is acting partially through an EGF-mediated pathway. © 2001 Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/80246
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYe, YNen_HK
dc.contributor.authorKoo, MWLen_HK
dc.contributor.authorLi, Yen_HK
dc.contributor.authorMatsui, Hen_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2010-09-06T08:04:10Z-
dc.date.available2010-09-06T08:04:10Z-
dc.date.issued2001en_HK
dc.identifier.citationLife Sciences, 2001, v. 68 n. 8, p. 961-968en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80246-
dc.description.abstractA crude extract from Angelica sinensis (ASCE), which mainly consists of polysaccharides, prevents ethanol- or indomethacin-induced gastric mucosal damage and promotes ulcer healing. The aim of this study was to test the hypothesis that ASCE has a direct stimulating effect on gastric epithelial cells for wound healing. We found that ASCE significantly promoted the migration of epithelial cells over an artificial wound on the surface of an RGM-1 monolayer. The extract also stimulated DNA synthesis in a dose-dependent manner and concomitantly increased EGF mRNA expression. Co-incubation of ASCE with anti-EGF antibody reduced the speed of migration and the DNA synthesis, which however were still higher than the control without ASCE. These results strongly suggest that ASCE has a direct wound healing effect on gastric mucosa, and this is acting partially through an EGF-mediated pathway. © 2001 Elsevier Science Inc.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.rightsLife Sciences. Copyright © Elsevier Inc.en_HK
dc.subjectAngelica sinensisen_HK
dc.subjectGastric epithelial cellsen_HK
dc.subjectMigrationen_HK
dc.subjectProliferationen_HK
dc.titleAngelica sinensis modulates migration and proliferation of gastric epithelial cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0024-3205&volume=68&spage=961&epage=968&date=2001&atitle=Angelica+sinensis+modulates+migration+and+proliferation+of+gastric+epithelial+cellsen_HK
dc.identifier.emailKoo, MWL: wlkoo@hku.hken_HK
dc.identifier.authorityKoo, MWL=rp00233en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0024-3205(00)00994-2en_HK
dc.identifier.pmid11213366-
dc.identifier.scopuseid_2-s2.0-0035846884en_HK
dc.identifier.hkuros61326en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035846884&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume68en_HK
dc.identifier.issue8en_HK
dc.identifier.spage961en_HK
dc.identifier.epage968en_HK
dc.identifier.isiWOS:000166536500012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYe, YN=7401627402en_HK
dc.identifier.scopusauthoridKoo, MWL=7004550899en_HK
dc.identifier.scopusauthoridLi, Y=54970596900en_HK
dc.identifier.scopusauthoridMatsui, H=7401527136en_HK
dc.identifier.scopusauthoridCho, CH=14067000400en_HK

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