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Article: Chinese green tea lowers cholesterol level through an increase in fecal lipid excretion

TitleChinese green tea lowers cholesterol level through an increase in fecal lipid excretion
Authors
KeywordsBile acids
Cholesterol
Cholesterol 7α-hydroxylase
Fatty acid synthase
Green tea
HMG-CoA reductase
Lung Chen tea
Issue Date1999
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1999, v. 66 n. 5, p. 411-423 How to Cite?
AbstractLung Chen Tea, a Chinese green tea, has been found to lower serum and liver cholesterol. In this study, its dose response and mechanisms of action on cholesterol lowering in diet-induced hypercholesterolemic Sprague-Dawley rats were investigated. The activities of three major lipid metabolizing enzymes, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-Co A) reductase, cholesterol 7α-hydroxylase and fatty acid synthase (FAS), as well as fecal excretion of bile acids and cholesterol were examined. Lung Chen Tea administration for eight weeks significantly lowered the serum cholesterol in the 2% and 4% groups. The activities of the three enzymes were not affected by Lung Chen Tea, but the fecal bile acids and cholesterol excretions were significantly increased. These results demonstrated that Lung Chen Tea lowered plasma cholesterol by increasing fecal bile acids and cholesterol excretion. Further investigation is required to evaluate the exact mechanisms of action of Lung Chen Tea.
Persistent Identifierhttp://hdl.handle.net/10722/80241
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, TTCen_HK
dc.contributor.authorKoo, MWLen_HK
dc.date.accessioned2010-09-06T08:04:06Z-
dc.date.available2010-09-06T08:04:06Z-
dc.date.issued1999en_HK
dc.identifier.citationLife Sciences, 1999, v. 66 n. 5, p. 411-423en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80241-
dc.description.abstractLung Chen Tea, a Chinese green tea, has been found to lower serum and liver cholesterol. In this study, its dose response and mechanisms of action on cholesterol lowering in diet-induced hypercholesterolemic Sprague-Dawley rats were investigated. The activities of three major lipid metabolizing enzymes, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-Co A) reductase, cholesterol 7α-hydroxylase and fatty acid synthase (FAS), as well as fecal excretion of bile acids and cholesterol were examined. Lung Chen Tea administration for eight weeks significantly lowered the serum cholesterol in the 2% and 4% groups. The activities of the three enzymes were not affected by Lung Chen Tea, but the fecal bile acids and cholesterol excretions were significantly increased. These results demonstrated that Lung Chen Tea lowered plasma cholesterol by increasing fecal bile acids and cholesterol excretion. Further investigation is required to evaluate the exact mechanisms of action of Lung Chen Tea.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.rightsLife Sciences. Copyright © Elsevier Inc.en_HK
dc.subjectBile acidsen_HK
dc.subjectCholesterolen_HK
dc.subjectCholesterol 7α-hydroxylaseen_HK
dc.subjectFatty acid synthaseen_HK
dc.subjectGreen teaen_HK
dc.subjectHMG-CoA reductaseen_HK
dc.subjectLung Chen teaen_HK
dc.titleChinese green tea lowers cholesterol level through an increase in fecal lipid excretionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0024-3205&volume=66 No 5&spage=411&epage=423&date=2000&atitle=Chinese+green+tea+lowers+cholesterol+level+through+an+increase+in+fecal+lipid+excretionen_HK
dc.identifier.emailKoo, MWL: wlkoo@hku.hken_HK
dc.identifier.authorityKoo, MWL=rp00233en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0024-3205(99)00607-4en_HK
dc.identifier.pmid10670829en_HK
dc.identifier.scopuseid_2-s2.0-0033579326en_HK
dc.identifier.hkuros52422en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033579326&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume66en_HK
dc.identifier.issue5en_HK
dc.identifier.spage411en_HK
dc.identifier.epage423en_HK
dc.identifier.isiWOS:000084403600005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYang, TTC=8075284700en_HK
dc.identifier.scopusauthoridKoo, MWL=7004550899en_HK

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