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Article: Genistein reduces agonist-induced contractions of porcine coronary arterial smooth muscle in a cyclic AMP-dependent manner

TitleGenistein reduces agonist-induced contractions of porcine coronary arterial smooth muscle in a cyclic AMP-dependent manner
Authors
KeywordsCoronary artery, porcine
Cyclic nucleotides
Genistein
Receptor-mediated contraction
Issue Date2004
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 2004, v. 503 n. 1-3, p. 165-172 How to Cite?
AbstractLow concentrations of genistein enhance the vasodilatation induced by endothelium-independent vasodilators. The present study examined whether or not low concentrations of genistein modulate contractions in isolated porcine coronary arteries. The role of second messengers in the response to genistein was also assessed. Arterial rings were studied in organ baths and contracted with KCl, U-46619 (9,11-dideoxy-9α, 11α-methanoepoxy prostaglandin F 2α), 5-hydroxytryptamine (5-HT) or endothelin-1 in the absence or presence of genistein (≤3 μM). Genistein significantly reduced agonist-induced but not KCl-induced contraction. Inhibition of endothelial nitric oxide synthase and disruption of endothelial function by Triton-X100 did not affect the modulation of contraction by genistein. The genistein-induced attenuation of contraction could be mimicked by both cAMP and cGMP analogs. However, only the cAMP-dependent protein kinase inhibitor, Rp-8-Br-cAMPS, abolished the effect of genistein. These results suggest that genistein reduces agonist-induced contraction by an endothelium-independent manner. This action is mediated via the cAMP-dependent signal transduction pathway. © 2004 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/80239
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, MYKen_HK
dc.contributor.authorLeung, SWSen_HK
dc.contributor.authorVanhoutte, PMen_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2010-09-06T08:04:05Z-
dc.date.available2010-09-06T08:04:05Z-
dc.date.issued2004en_HK
dc.identifier.citationEuropean Journal Of Pharmacology, 2004, v. 503 n. 1-3, p. 165-172en_HK
dc.identifier.issn0014-2999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80239-
dc.description.abstractLow concentrations of genistein enhance the vasodilatation induced by endothelium-independent vasodilators. The present study examined whether or not low concentrations of genistein modulate contractions in isolated porcine coronary arteries. The role of second messengers in the response to genistein was also assessed. Arterial rings were studied in organ baths and contracted with KCl, U-46619 (9,11-dideoxy-9α, 11α-methanoepoxy prostaglandin F 2α), 5-hydroxytryptamine (5-HT) or endothelin-1 in the absence or presence of genistein (≤3 μM). Genistein significantly reduced agonist-induced but not KCl-induced contraction. Inhibition of endothelial nitric oxide synthase and disruption of endothelial function by Triton-X100 did not affect the modulation of contraction by genistein. The genistein-induced attenuation of contraction could be mimicked by both cAMP and cGMP analogs. However, only the cAMP-dependent protein kinase inhibitor, Rp-8-Br-cAMPS, abolished the effect of genistein. These results suggest that genistein reduces agonist-induced contraction by an endothelium-independent manner. This action is mediated via the cAMP-dependent signal transduction pathway. © 2004 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_HK
dc.relation.ispartofEuropean Journal of Pharmacologyen_HK
dc.rightsEuropean Journal of Pharmacology. Copyright © Elsevier BV.en_HK
dc.subjectCoronary artery, porcineen_HK
dc.subjectCyclic nucleotidesen_HK
dc.subjectGenisteinen_HK
dc.subjectReceptor-mediated contractionen_HK
dc.titleGenistein reduces agonist-induced contractions of porcine coronary arterial smooth muscle in a cyclic AMP-dependent manneren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-2999&volume=503&spage=165&epage=172&date=2004&atitle=Genistein+reduces+agonist-induced+contractions+of+porcine+coronary+arterial+smooth+muscle+in+a+cyclic+AMP-dependent+manneren_HK
dc.identifier.emailLeung, SWS: swsleung@hku.hken_HK
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SWS=rp00235en_HK
dc.identifier.authorityVanhoutte, PM=rp00238en_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejphar.2004.09.028en_HK
dc.identifier.pmid15496311-
dc.identifier.scopuseid_2-s2.0-7444269548en_HK
dc.identifier.hkuros97510en_HK
dc.identifier.hkuros147811-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-7444269548&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume503en_HK
dc.identifier.issue1-3en_HK
dc.identifier.spage165en_HK
dc.identifier.epage172en_HK
dc.identifier.isiWOS:000225058600024-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLee, MYK=22980015700en_HK
dc.identifier.scopusauthoridLeung, SWS=24540419500en_HK
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK

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