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Article: Differential effects of selective and non-selective inhibition of nitric oxide synthase on the expression and activity of cyclooxygenase-2 during gastric ulcer healing

TitleDifferential effects of selective and non-selective inhibition of nitric oxide synthase on the expression and activity of cyclooxygenase-2 during gastric ulcer healing
Authors
KeywordsCOX-2 (cyclooxygenase-2)
eNOS (endothelial nitric oxide synthase)
iNOS (inducible nitric oxide synthase)
L-NAME (NG-nitro-l-arginine methyl ester)
N-(3-(aminomethyl)benzyl)acetamidine (1400W)
NF-κB (nuclear transcription factor κB)
Issue Date2006
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 2006, v. 536 n. 3, p. 301-308 How to Cite?
AbstractNitric oxide synthases (NOS) and cyclooxygenase-2 (COX-2) are important enzymes involved in ulcer healing but interactions between them have not been clearly defined. The aim of this study was to investigate the effects of selective or non-selective inhibition of NOS on the expression and activity of COX-2 during healing of acetic acid-induced gastric ulcers in rats. N-[3-(aminomethyl)benzyl] acetamidine (1400W), a potent selective inhibitor of inducible nitric oxide synthase (iNOS), at a dose of 0.1 mg/kg/day, was found to reduce the ulcer sizes at day 3 and 7 post-ulcer induction. On the other hand, 15 mg/kg/day of NG-nitro-l-arginine methyl ester (l-NAME), a non-selective NOS inhibitor that suppresses both iNOS and endothelial nitric oxide synthase (eNOS), enlarged the ulcer sizes over the same time periods. The expression of COX-2 and COX activity, together with NF-κB activation in the ulcer tissues were down-regulated by l-NAME but not 1400W. It is concluded that iNOS may contribute to ulcer formation while COX-2 and eNOS promote ulcer healing. eNOS enhances COX-2 expression possibly through the activation of NF-κB. © 2006 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/80237
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuo, JSen_HK
dc.contributor.authorCho, CHen_HK
dc.contributor.authorWang, JYen_HK
dc.contributor.authorKoo, MWLen_HK
dc.date.accessioned2010-09-06T08:04:03Z-
dc.date.available2010-09-06T08:04:03Z-
dc.date.issued2006en_HK
dc.identifier.citationEuropean Journal Of Pharmacology, 2006, v. 536 n. 3, p. 301-308en_HK
dc.identifier.issn0014-2999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80237-
dc.description.abstractNitric oxide synthases (NOS) and cyclooxygenase-2 (COX-2) are important enzymes involved in ulcer healing but interactions between them have not been clearly defined. The aim of this study was to investigate the effects of selective or non-selective inhibition of NOS on the expression and activity of COX-2 during healing of acetic acid-induced gastric ulcers in rats. N-[3-(aminomethyl)benzyl] acetamidine (1400W), a potent selective inhibitor of inducible nitric oxide synthase (iNOS), at a dose of 0.1 mg/kg/day, was found to reduce the ulcer sizes at day 3 and 7 post-ulcer induction. On the other hand, 15 mg/kg/day of NG-nitro-l-arginine methyl ester (l-NAME), a non-selective NOS inhibitor that suppresses both iNOS and endothelial nitric oxide synthase (eNOS), enlarged the ulcer sizes over the same time periods. The expression of COX-2 and COX activity, together with NF-κB activation in the ulcer tissues were down-regulated by l-NAME but not 1400W. It is concluded that iNOS may contribute to ulcer formation while COX-2 and eNOS promote ulcer healing. eNOS enhances COX-2 expression possibly through the activation of NF-κB. © 2006 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_HK
dc.relation.ispartofEuropean Journal of Pharmacologyen_HK
dc.rightsEuropean Journal of Pharmacology. Copyright © Elsevier BV.en_HK
dc.subjectCOX-2 (cyclooxygenase-2)en_HK
dc.subjecteNOS (endothelial nitric oxide synthase)en_HK
dc.subjectiNOS (inducible nitric oxide synthase)en_HK
dc.subjectL-NAME (NG-nitro-l-arginine methyl ester)en_HK
dc.subjectN-(3-(aminomethyl)benzyl)acetamidine (1400W)en_HK
dc.subjectNF-κB (nuclear transcription factor κB)en_HK
dc.titleDifferential effects of selective and non-selective inhibition of nitric oxide synthase on the expression and activity of cyclooxygenase-2 during gastric ulcer healingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-2999&volume=536&spage=301&epage=308&date=2006&atitle=Differential+effects+of+selective+and+non-selective+inhibition+of+nitric+oxide+synthase+on+the+expression+and+activity+of+cyclooxygenase-2+during+gastric+ulcer+healingen_HK
dc.identifier.emailKoo, MWL: wlkoo@hku.hken_HK
dc.identifier.authorityKoo, MWL=rp00233en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejphar.2005.12.088en_HK
dc.identifier.pmid16600210en_HK
dc.identifier.scopuseid_2-s2.0-33646470979en_HK
dc.identifier.hkuros119513en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646470979&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume536en_HK
dc.identifier.issue3en_HK
dc.identifier.spage301en_HK
dc.identifier.epage308en_HK
dc.identifier.isiWOS:000237407700012-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridGuo, JS=7404488815en_HK
dc.identifier.scopusauthoridCho, CH=7403100461en_HK
dc.identifier.scopusauthoridWang, JY=8071004900en_HK
dc.identifier.scopusauthoridKoo, MWL=7004550899en_HK

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