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Article: Worsening effect of partial sleep deprivation on indomethacin-induced gastric mucosal damage

TitleWorsening effect of partial sleep deprivation on indomethacin-induced gastric mucosal damage
Authors
KeywordsCyclooxygenase
Indomethacin
Partial sleep deprivation
Prostaglandin
Stress
Issue Date2005
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembeh
Citation
Pharmacology Biochemistry And Behavior, 2005, v. 82 n. 3, p. 515-521 How to Cite?
AbstractThe present study was to investigate the roles of cyclooxygenase-1 and -2 (COX-1 and COX-2) and prostaglandin (PG) on gastric mucosal integrity of partially sleep deprived (PSD) rats. A slowly moving drum was used to induce PSD. The PG levels in the gastric mucosa of PSD rats, with or without indomethacin or rofecoxib treatment, were determined. Exogenous prostaglandin E (PGE) analog, misoprostol, was administered to PSD rats to investigate the modulating effect of PG in indomethacin-induced gastric damage. It was observed that COX-1 mRNA and protein were up-regulated in the gastric mucosa of PSD rats. Selective COX-2 inhibition by rofecoxib failed to decrease mucosal PGE 2 levels nor to affect mucosal integrity in both PSD and sleep undisturbed rats. However, indomethacin, a COX-1 preferential non-selective COX inhibitor, significantly reduced mucosal PGE2 content and produced more severe mucosal damage in PSD rats than in the controls. The deleterious effect of indomethacin on gastric mucosal integrity of PSD rats was significantly attenuated with the administration of misoprostol. These results suggest that PSD enhances COX-1 biosynthesis of gastroprotective PGE2 as an adaptive response of the stomach to stress. The administration of non-selective COX inhibitors to subjects with chronic sleep deprivation may induce more gastric damages. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/80235
ISSN
2015 Impact Factor: 2.537
2015 SCImago Journal Rankings: 1.121
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuo, JSen_HK
dc.contributor.authorChau, FLen_HK
dc.contributor.authorCho, CHen_HK
dc.contributor.authorKoo, MWLen_HK
dc.date.accessioned2010-09-06T08:04:02Z-
dc.date.available2010-09-06T08:04:02Z-
dc.date.issued2005en_HK
dc.identifier.citationPharmacology Biochemistry And Behavior, 2005, v. 82 n. 3, p. 515-521en_HK
dc.identifier.issn0091-3057en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80235-
dc.description.abstractThe present study was to investigate the roles of cyclooxygenase-1 and -2 (COX-1 and COX-2) and prostaglandin (PG) on gastric mucosal integrity of partially sleep deprived (PSD) rats. A slowly moving drum was used to induce PSD. The PG levels in the gastric mucosa of PSD rats, with or without indomethacin or rofecoxib treatment, were determined. Exogenous prostaglandin E (PGE) analog, misoprostol, was administered to PSD rats to investigate the modulating effect of PG in indomethacin-induced gastric damage. It was observed that COX-1 mRNA and protein were up-regulated in the gastric mucosa of PSD rats. Selective COX-2 inhibition by rofecoxib failed to decrease mucosal PGE 2 levels nor to affect mucosal integrity in both PSD and sleep undisturbed rats. However, indomethacin, a COX-1 preferential non-selective COX inhibitor, significantly reduced mucosal PGE2 content and produced more severe mucosal damage in PSD rats than in the controls. The deleterious effect of indomethacin on gastric mucosal integrity of PSD rats was significantly attenuated with the administration of misoprostol. These results suggest that PSD enhances COX-1 biosynthesis of gastroprotective PGE2 as an adaptive response of the stomach to stress. The administration of non-selective COX inhibitors to subjects with chronic sleep deprivation may induce more gastric damages. © 2005 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembehen_HK
dc.relation.ispartofPharmacology Biochemistry and Behavioren_HK
dc.rightsPharmacology, Biochemistry and Behavior . Copyright © Elsevier Inc.en_HK
dc.subjectCyclooxygenaseen_HK
dc.subjectIndomethacinen_HK
dc.subjectPartial sleep deprivationen_HK
dc.subjectProstaglandinen_HK
dc.subjectStressen_HK
dc.titleWorsening effect of partial sleep deprivation on indomethacin-induced gastric mucosal damageen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0091-3057&volume=82&spage=515&epage=521&date=2005&atitle=Worsening+effect+of+partial+sleep+deprivation+on+indomethacin-induced+gastric+mucosal+damageen_HK
dc.identifier.emailKoo, MWL: wlkoo@hku.hken_HK
dc.identifier.authorityKoo, MWL=rp00233en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.pbb.2005.10.006en_HK
dc.identifier.pmid16343605-
dc.identifier.scopuseid_2-s2.0-29244440833en_HK
dc.identifier.hkuros119239en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-29244440833&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume82en_HK
dc.identifier.issue3en_HK
dc.identifier.spage515en_HK
dc.identifier.epage521en_HK
dc.identifier.isiWOS:000234623700011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGuo, JS=7404488815en_HK
dc.identifier.scopusauthoridChau, FL=10140226100en_HK
dc.identifier.scopusauthoridCho, CH=7403100461en_HK
dc.identifier.scopusauthoridKoo, MWL=7004550899en_HK

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