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Article: Endothelial dysfunction: A multifaceted disorder

TitleEndothelial dysfunction: A multifaceted disorder
Authors
KeywordsAngioplasty
Endothelin
Endothelium-derived contracting factor
Endothelium-derived hperpolarizing factor
Hypertension
Nitric oxide
Oxidative stress
Prostaglandins
Regenerated endothelium
Superoxide anion
Issue Date2006
PublisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpheart.physiology.org/
Citation
American Journal Of Physiology - Heart And Circulatory Physiology, 2006, v. 291 n. 3, p. H985-H1002 How to Cite?
AbstractEndothelial cells synthesize and release various factors that regulate angiogenesis, inflammatory responses, hemostasis, as well as vascular tone and permeability. Endothelial dysfunction has been associated with a number of pathophysiological processes. Oxidative stress appears to be a common denominator underlying endothelial dysfunction in cardiovascular diseases. However, depending on the pathology, the vascular bed studied, the stimulant, and additional factors such as age, sex, salt intake, cholesterolemia, glycemia, and hyperhomocysteinemia, the mechanisms underlying the endothelial dysfunction can be markedly different. A reduced bioavailability of nitric oxide (NO), an alteration in the production of prostanoids, including prostacyclin, thromboxane A 2, and/or isoprostanes, an impairment of endothelium-dependent hyperpolarization, as well as an increased release of endothelin-1, can individually or in association contribute to endothelial dysfunction. Therapeutic interventions do not necessarily restore a proper endothelial function and, when they do, may improve only part of these variables. Copyright © 2006 the American Physiological Society.
Persistent Identifierhttp://hdl.handle.net/10722/80232
ISSN
2015 Impact Factor: 3.324
2015 SCImago Journal Rankings: 1.823
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFélétou, Men_HK
dc.contributor.authorVanhoutte, PMen_HK
dc.date.accessioned2010-09-06T08:04:00Z-
dc.date.available2010-09-06T08:04:00Z-
dc.date.issued2006en_HK
dc.identifier.citationAmerican Journal Of Physiology - Heart And Circulatory Physiology, 2006, v. 291 n. 3, p. H985-H1002en_HK
dc.identifier.issn0363-6135en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80232-
dc.description.abstractEndothelial cells synthesize and release various factors that regulate angiogenesis, inflammatory responses, hemostasis, as well as vascular tone and permeability. Endothelial dysfunction has been associated with a number of pathophysiological processes. Oxidative stress appears to be a common denominator underlying endothelial dysfunction in cardiovascular diseases. However, depending on the pathology, the vascular bed studied, the stimulant, and additional factors such as age, sex, salt intake, cholesterolemia, glycemia, and hyperhomocysteinemia, the mechanisms underlying the endothelial dysfunction can be markedly different. A reduced bioavailability of nitric oxide (NO), an alteration in the production of prostanoids, including prostacyclin, thromboxane A 2, and/or isoprostanes, an impairment of endothelium-dependent hyperpolarization, as well as an increased release of endothelin-1, can individually or in association contribute to endothelial dysfunction. Therapeutic interventions do not necessarily restore a proper endothelial function and, when they do, may improve only part of these variables. Copyright © 2006 the American Physiological Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpheart.physiology.org/en_HK
dc.relation.ispartofAmerican Journal of Physiology - Heart and Circulatory Physiologyen_HK
dc.subjectAngioplastyen_HK
dc.subjectEndothelinen_HK
dc.subjectEndothelium-derived contracting factoren_HK
dc.subjectEndothelium-derived hperpolarizing factoren_HK
dc.subjectHypertensionen_HK
dc.subjectNitric oxideen_HK
dc.subjectOxidative stressen_HK
dc.subjectProstaglandinsen_HK
dc.subjectRegenerated endotheliumen_HK
dc.subjectSuperoxide anionen_HK
dc.titleEndothelial dysfunction: A multifaceted disorderen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0363-6135&volume=291&spage=H985&epage=H1002&date=2006&atitle=Endothelial+dysfunction:+a+multifaceted+disorderen_HK
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_HK
dc.identifier.authorityVanhoutte, PM=rp00238en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1152/ajpheart.00292.2006en_HK
dc.identifier.pmid16632549-
dc.identifier.scopuseid_2-s2.0-33748421398en_HK
dc.identifier.hkuros123430en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33748421398&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume291en_HK
dc.identifier.issue3en_HK
dc.identifier.spageH985en_HK
dc.identifier.epageH1002en_HK
dc.identifier.isiWOS:000239680000001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridFélétou, M=7006461826en_HK
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_HK

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