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Conference Paper: Acute exposure to a low level of testosterone impairs relaxation in porcine coronary arteries

TitleAcute exposure to a low level of testosterone impairs relaxation in porcine coronary arteries
Authors
Keywords17β-oestradiol
Endothelium-dependent relaxation
Endothelium-independent relaxation
Oestrogen
Porcine coronary artery
Testosterone
Issue Date1999
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP
Citation
2nd Scientific Symposium of Cardiovascular Science Across the Strait, Dalian, People's Republic of China, 20-23 APR 1998. In Clinical And Experimental Pharmacology And Physiology, 1999, v. 26 n. 10, p. 830-832 How to Cite?
Abstract1. While the gender bias associated with coronary artery disease has been suggested to be partially accounted for by the protective effects of oestrogens, the role of testosterone remains unclear. The aim of the present study was to determine whether vasorelaxation could be affected by acute administration of testosterone with and without 17β-oestradiol. 2. Precontracted porcine coronary artery rings were relaxed with sodium nitroprusside (SNP), leveromakalim, bradykinin (BK) or A23187. At 1 nmol/L, testosterone impaired relaxations to BK and A23187, while the same concentration of 17β-oestradiol potentiated levcromakalim- and SNP-induced relaxations. The impairment of relaxation responses by testosterone was reduced in the presence of 17β-oestradiol, while the enhancement by 17β- oestradiol was decreased by testosterone. 3. We demonstrate that a low level of testosterone can impair agonist-induced relaxation, an effect that is reduced by 17β-oestradiol. This further supports evidence indicating a detrimental role for testosterone in coronary artery disease and suggests that circulating levels of testosterone may undermine the beneficial effects of oestrogen in women.
Persistent Identifierhttp://hdl.handle.net/10722/80231
ISSN
2012 Impact Factor: 2.16
2015 SCImago Journal Rankings: 0.944
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQuan, Aen_HK
dc.contributor.authorTeoh, Hen_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2010-09-06T08:03:59Z-
dc.date.available2010-09-06T08:03:59Z-
dc.date.issued1999en_HK
dc.identifier.citation2nd Scientific Symposium of Cardiovascular Science Across the Strait, Dalian, People's Republic of China, 20-23 APR 1998. In Clinical And Experimental Pharmacology And Physiology, 1999, v. 26 n. 10, p. 830-832en_HK
dc.identifier.issn0305-1870en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80231-
dc.description.abstract1. While the gender bias associated with coronary artery disease has been suggested to be partially accounted for by the protective effects of oestrogens, the role of testosterone remains unclear. The aim of the present study was to determine whether vasorelaxation could be affected by acute administration of testosterone with and without 17β-oestradiol. 2. Precontracted porcine coronary artery rings were relaxed with sodium nitroprusside (SNP), leveromakalim, bradykinin (BK) or A23187. At 1 nmol/L, testosterone impaired relaxations to BK and A23187, while the same concentration of 17β-oestradiol potentiated levcromakalim- and SNP-induced relaxations. The impairment of relaxation responses by testosterone was reduced in the presence of 17β-oestradiol, while the enhancement by 17β- oestradiol was decreased by testosterone. 3. We demonstrate that a low level of testosterone can impair agonist-induced relaxation, an effect that is reduced by 17β-oestradiol. This further supports evidence indicating a detrimental role for testosterone in coronary artery disease and suggests that circulating levels of testosterone may undermine the beneficial effects of oestrogen in women.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEPen_HK
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_HK
dc.subject17β-oestradiolen_HK
dc.subjectEndothelium-dependent relaxationen_HK
dc.subjectEndothelium-independent relaxationen_HK
dc.subjectOestrogenen_HK
dc.subjectPorcine coronary arteryen_HK
dc.subjectTestosteroneen_HK
dc.titleAcute exposure to a low level of testosterone impairs relaxation in porcine coronary arteriesen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0305-1870&volume=26&spage=830&epage=832&date=1999&atitle=Acute+exposure+to+a+low+level+of+testosterone+impairs+relaxation+in+porcine+coronary+arteriesen_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1440-1681.1999.03138.xen_HK
dc.identifier.pmid10549414-
dc.identifier.scopuseid_2-s2.0-0032883774en_HK
dc.identifier.hkuros50113en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032883774&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue10en_HK
dc.identifier.spage830en_HK
dc.identifier.epage832en_HK
dc.identifier.isiWOS:000082846500019-
dc.publisher.placeAustraliaen_HK
dc.description.other2nd Scientific Symposium of Cardiovascular Science Across the Strait, Dalian, People's Republic of China, 20-23 APR 1998. In Clinical And Experimental Pharmacology And Physiology, 1999, v. 26 n. 10, p. 830-832-
dc.identifier.scopusauthoridQuan, A=7006871453en_HK
dc.identifier.scopusauthoridTeoh, H=7003816542en_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK

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