File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Partial sleep deprivation compromises gastric mucosal integrity in rats

TitlePartial sleep deprivation compromises gastric mucosal integrity in rats
Authors
KeywordsGastric acidity
Gastric mucosal damage
Gastrin
Histamine
Noradrenaline
Partial sleep deprivation
Somatostatin
Issue Date2005
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 2005, v. 77 n. 2, p. 220-229 How to Cite?
AbstractThe gastric mucosa is most susceptible to stress that has been shown to induce mucosal damage in humans and animals. This study aims to explore the underlying mechanisms of partial sleep deprivation, as a source of psychophysiological stress, on gastric functions and its effect on mucosal integrity. Sprague-Dawley rats were partially sleep deprived (PSD) for 7 or 14 days by housing inside slowly rotating drums. Gastric tissues and plasma were sampled at the end of the sleep deprivation periods and mucosal lesion scores were evaluated. Morphological examination was performed after Hematoxylin and Eosin staining. Plasma levels of noradrenaline, adrenaline, gastrin, histamine and somatostatin were determined with enzyme immunoassays. Gastric acidity was measured with acid-base titration in pylorus ligated rats. Gastric mucosal blood flow was evaluated with Laser Doppler Flowmetry. It was found that gastric lesions were induced in about 30%-50% of the PSD rats. Gastric acidity as well as plasma levels of noradrenaline, gastrin and histamine were elevated. Gastric mucosal blood flow and plasma somatostatin level were on the contrary reduced, especially in rats with PSD for 14 days. It is concluded that partial sleep deprivation compromises gastric mucosal integrity by increasing gastric acidity, plasma levels of noradrenaline, gastrin, histamine, and decreasing gastric mucosal blood flow. These results provided experimental evidence on the gastric damaging effects of PSD and it could be one of the risk factors contributing to gastric ulcer formation. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/80224
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJin, SGen_HK
dc.contributor.authorChau, JFLen_HK
dc.contributor.authorChi, HCen_HK
dc.contributor.authorKoo, MWLen_HK
dc.date.accessioned2010-09-06T08:03:54Z-
dc.date.available2010-09-06T08:03:54Z-
dc.date.issued2005en_HK
dc.identifier.citationLife Sciences, 2005, v. 77 n. 2, p. 220-229en_HK
dc.identifier.issn0024-3205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80224-
dc.description.abstractThe gastric mucosa is most susceptible to stress that has been shown to induce mucosal damage in humans and animals. This study aims to explore the underlying mechanisms of partial sleep deprivation, as a source of psychophysiological stress, on gastric functions and its effect on mucosal integrity. Sprague-Dawley rats were partially sleep deprived (PSD) for 7 or 14 days by housing inside slowly rotating drums. Gastric tissues and plasma were sampled at the end of the sleep deprivation periods and mucosal lesion scores were evaluated. Morphological examination was performed after Hematoxylin and Eosin staining. Plasma levels of noradrenaline, adrenaline, gastrin, histamine and somatostatin were determined with enzyme immunoassays. Gastric acidity was measured with acid-base titration in pylorus ligated rats. Gastric mucosal blood flow was evaluated with Laser Doppler Flowmetry. It was found that gastric lesions were induced in about 30%-50% of the PSD rats. Gastric acidity as well as plasma levels of noradrenaline, gastrin and histamine were elevated. Gastric mucosal blood flow and plasma somatostatin level were on the contrary reduced, especially in rats with PSD for 14 days. It is concluded that partial sleep deprivation compromises gastric mucosal integrity by increasing gastric acidity, plasma levels of noradrenaline, gastrin, histamine, and decreasing gastric mucosal blood flow. These results provided experimental evidence on the gastric damaging effects of PSD and it could be one of the risk factors contributing to gastric ulcer formation. © 2005 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_HK
dc.relation.ispartofLife Sciencesen_HK
dc.rightsLife Sciences. Copyright © Elsevier Inc.en_HK
dc.subjectGastric acidityen_HK
dc.subjectGastric mucosal damageen_HK
dc.subjectGastrinen_HK
dc.subjectHistamineen_HK
dc.subjectNoradrenalineen_HK
dc.subjectPartial sleep deprivationen_HK
dc.subjectSomatostatinen_HK
dc.titlePartial sleep deprivation compromises gastric mucosal integrity in ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0024-3205&volume=77 &issue=2005&spage=220&epage=229&date=2005&atitle=Partial+sleep+deprivation+compromises+gastric+mucosal+integrity+in+ratsen_HK
dc.identifier.emailKoo, MWL: wlkoo@hku.hken_HK
dc.identifier.authorityKoo, MWL=rp00233en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.lfs.2004.12.027en_HK
dc.identifier.pmid15862606en_HK
dc.identifier.scopuseid_2-s2.0-18044383512en_HK
dc.identifier.hkuros104939en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18044383512&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume77en_HK
dc.identifier.issue2en_HK
dc.identifier.spage220en_HK
dc.identifier.epage229en_HK
dc.identifier.isiWOS:000229047300010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridJin, SG=8415019300en_HK
dc.identifier.scopusauthoridChau, JFL=9236841800en_HK
dc.identifier.scopusauthoridChi, HC=8415019500en_HK
dc.identifier.scopusauthoridKoo, MWL=7004550899en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats