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Article: Progesterone modulates estradiol actions: Acute effects at physiological concentrations

TitleProgesterone modulates estradiol actions: Acute effects at physiological concentrations
Authors
Keywords17β-Estradiol
Coronary artery
Porcine
Progesterone
Vasorelaxation
Issue Date1999
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 1999, v. 378 n. 1, p. 57-62 How to Cite?
AbstractThe progestin element of hormone replacement therapy may reduce the cardioprotective actions of the estrogen component. Only high concentrations (μM) of progesterone directly relaxed U46619 (9,11-dideoxy-9α, 11α-methanoepoxy prostaglandin F2α)-pre-contracted porcine coronary artery rings. A low concentration of progesterone (1 nM), with no effects of its own, shifted the relaxation curves of bradykinin and calcium ionophore A23187 to the right while not affecting those of sodium nitroprusside and levcromakalim. The negative influence that 1 nM progesterone exerted on bradykinin- and A23187-mediated relaxation was diminished when 1 nM 17β-estradiol was concomitantly added to the bathing medium. Conversely, the potentiating actions of 1 nM 17β-estradiol on relaxations elicited by sodium nitroprusside and levcromakalim were reduced following simultaneous treatment with the same concentrations of progesterone. These findings represent the first evidence for an acute in vitro vascular effect of progesterone at a physiologically relevant concentration and concur with previous in vivo reports demonstrating that progesterone may diminish the beneficial effects of estrogens. Copyright (C) 1999 Elsevier Science B.V.
Persistent Identifierhttp://hdl.handle.net/10722/80220
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTeoh, Hen_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2010-09-06T08:03:52Z-
dc.date.available2010-09-06T08:03:52Z-
dc.date.issued1999en_HK
dc.identifier.citationEuropean Journal Of Pharmacology, 1999, v. 378 n. 1, p. 57-62en_HK
dc.identifier.issn0014-2999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80220-
dc.description.abstractThe progestin element of hormone replacement therapy may reduce the cardioprotective actions of the estrogen component. Only high concentrations (μM) of progesterone directly relaxed U46619 (9,11-dideoxy-9α, 11α-methanoepoxy prostaglandin F2α)-pre-contracted porcine coronary artery rings. A low concentration of progesterone (1 nM), with no effects of its own, shifted the relaxation curves of bradykinin and calcium ionophore A23187 to the right while not affecting those of sodium nitroprusside and levcromakalim. The negative influence that 1 nM progesterone exerted on bradykinin- and A23187-mediated relaxation was diminished when 1 nM 17β-estradiol was concomitantly added to the bathing medium. Conversely, the potentiating actions of 1 nM 17β-estradiol on relaxations elicited by sodium nitroprusside and levcromakalim were reduced following simultaneous treatment with the same concentrations of progesterone. These findings represent the first evidence for an acute in vitro vascular effect of progesterone at a physiologically relevant concentration and concur with previous in vivo reports demonstrating that progesterone may diminish the beneficial effects of estrogens. Copyright (C) 1999 Elsevier Science B.V.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_HK
dc.relation.ispartofEuropean Journal of Pharmacologyen_HK
dc.rightsEuropean Journal of Pharmacology. Copyright © Elsevier BV.en_HK
dc.subject17β-Estradiolen_HK
dc.subjectCoronary arteryen_HK
dc.subjectPorcineen_HK
dc.subjectProgesteroneen_HK
dc.subjectVasorelaxationen_HK
dc.titleProgesterone modulates estradiol actions: Acute effects at physiological concentrationsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-2999&volume=378&spage=57&epage=62&date=1999&atitle=Progesterone+modulates+estradiol+actions:+acute+effects+at+physiological+concentrationsen_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0014-2999(99)00438-0en_HK
dc.identifier.pmid10478565-
dc.identifier.scopuseid_2-s2.0-0032780428en_HK
dc.identifier.hkuros50110en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032780428&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume378en_HK
dc.identifier.issue1en_HK
dc.identifier.spage57en_HK
dc.identifier.epage62en_HK
dc.identifier.isiWOS:000081841700008-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridTeoh, H=7003816542en_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK

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