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Article: The phytoestrogen genistein enhances endothelium-independent relaxation in the porcine coronary artery

TitleThe phytoestrogen genistein enhances endothelium-independent relaxation in the porcine coronary artery
Authors
KeywordsGenistein
Phytoestrogen
Smooth muscle
Vasodilatation
Issue Date2003
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 2003, v. 481 n. 2-3, p. 227-232 How to Cite?
AbstractGenistein, a phytoestrogen, possesses cardioprotective effects. Responses to genistein (0.1-100 μM) were assessed in 9,11-dideoxy-9α, 11α-methanoepoxy prostaglandin F2α (U46619)-contracted porcine coronary arterial rings, with significant relaxations at high concentrations. At concentrations with little relaxation, genistein (0.3-3 μM) did not affect relaxation produced by bradykinin and the calcium ionophore, A23187. In contrast, sodium nitroprusside- and cromakalim-induced relaxations were enhanced by genistein (3 μM). Nω-nitro-L- arginine methyl ester (L-NAME) (300 μM) or Triton X-100 (0.5%) did not affect the enhancement of relaxation by genistein. The tyrosine kinase inhibitor, tyrphostin 23 (30 μM), had no effect on sodium nitroprusside-elicited relaxation. In summary, genistein relaxed porcine coronary artery at relatively high concentrations. At a physiologically relevant concentration (3 μM), it is devoid of significant vascular effect, but enhanced endothelium-independent relaxations. This effect of genistein does not involve the nitric oxide synthase (NOS) pathway and the endothelium, and is mediated through a mechanism different from tyrosine kinase inhibition. © 2003 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/80218
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, MYKen_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2010-09-06T08:03:50Z-
dc.date.available2010-09-06T08:03:50Z-
dc.date.issued2003en_HK
dc.identifier.citationEuropean Journal Of Pharmacology, 2003, v. 481 n. 2-3, p. 227-232en_HK
dc.identifier.issn0014-2999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80218-
dc.description.abstractGenistein, a phytoestrogen, possesses cardioprotective effects. Responses to genistein (0.1-100 μM) were assessed in 9,11-dideoxy-9α, 11α-methanoepoxy prostaglandin F2α (U46619)-contracted porcine coronary arterial rings, with significant relaxations at high concentrations. At concentrations with little relaxation, genistein (0.3-3 μM) did not affect relaxation produced by bradykinin and the calcium ionophore, A23187. In contrast, sodium nitroprusside- and cromakalim-induced relaxations were enhanced by genistein (3 μM). Nω-nitro-L- arginine methyl ester (L-NAME) (300 μM) or Triton X-100 (0.5%) did not affect the enhancement of relaxation by genistein. The tyrosine kinase inhibitor, tyrphostin 23 (30 μM), had no effect on sodium nitroprusside-elicited relaxation. In summary, genistein relaxed porcine coronary artery at relatively high concentrations. At a physiologically relevant concentration (3 μM), it is devoid of significant vascular effect, but enhanced endothelium-independent relaxations. This effect of genistein does not involve the nitric oxide synthase (NOS) pathway and the endothelium, and is mediated through a mechanism different from tyrosine kinase inhibition. © 2003 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_HK
dc.relation.ispartofEuropean Journal of Pharmacologyen_HK
dc.rightsEuropean Journal of Pharmacology. Copyright © Elsevier BV.en_HK
dc.subjectGenisteinen_HK
dc.subjectPhytoestrogenen_HK
dc.subjectSmooth muscleen_HK
dc.subjectVasodilatationen_HK
dc.titleThe phytoestrogen genistein enhances endothelium-independent relaxation in the porcine coronary arteryen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-2999&volume=481&spage=227&epage=232 &date=2003&atitle=The+phytoestrogen+genistein+enhances+endothelium-independent+relaxation+in+the+porcine+coronary+artery.+en_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejphar.2003.09.028en_HK
dc.identifier.pmid14642790-
dc.identifier.scopuseid_2-s2.0-0344395548en_HK
dc.identifier.hkuros147812en_HK
dc.identifier.hkuros85972-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0344395548&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume481en_HK
dc.identifier.issue2-3en_HK
dc.identifier.spage227en_HK
dc.identifier.epage232en_HK
dc.identifier.isiWOS:000186925400014-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLee, MYK=22980015700en_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK

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