File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The role of mitochondrial and plasma membrane nucleoside transporters in drug toxicity

TitleThe role of mitochondrial and plasma membrane nucleoside transporters in drug toxicity
Authors
KeywordsAnticancer
Antiviral
Mitochondria
Nucleoside
Toxicity
Transporter
Issue Date2007
PublisherInforma Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/emt
Citation
Expert Opinion On Drug Metabolism And Toxicology, 2007, v. 3 n. 5, p. 705-718 How to Cite?
AbstractMany anticancer and antiviral drugs are nucleoside analogues, which interfere with nucleotide metabolism and DNA replication to produce pharmacological effects. Clinical efficacy and toxicity of nucleoside drugs are closely associated with nucleoside transporters because they mediate the transport of nucleoside drugs across biological membranes. Two families of human nucleoside transporters (equilibrative nucleoside transporters and concentrative nucleoside transporters) have been extensively studied for several decades. They are widely distributed, from the plasma membrane to membranes of organelles such as mitochondria, and the distribution differs in different tissues. In addition, they have different specificities to nucleoside drugs. The characteristics of equilibrative and concentrative nucleoside transporters affect the therapeutic outcomes achieved with anticancer and antiviral nucleoside drugs. In this review, an overview of the role of mitochondrial and plasma membrane nucleoside transporters in nucleoside drug toxicity is provided. Rational design and therapeutic application of nucleoside analogues are also discussed. © 2007 Informa UK Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/80216
ISSN
2015 Impact Factor: 2.598
2015 SCImago Journal Rankings: 0.866
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, GPHen_HK
dc.contributor.authorTse, CMen_HK
dc.date.accessioned2010-09-06T08:03:49Z-
dc.date.available2010-09-06T08:03:49Z-
dc.date.issued2007en_HK
dc.identifier.citationExpert Opinion On Drug Metabolism And Toxicology, 2007, v. 3 n. 5, p. 705-718en_HK
dc.identifier.issn1742-5255en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80216-
dc.description.abstractMany anticancer and antiviral drugs are nucleoside analogues, which interfere with nucleotide metabolism and DNA replication to produce pharmacological effects. Clinical efficacy and toxicity of nucleoside drugs are closely associated with nucleoside transporters because they mediate the transport of nucleoside drugs across biological membranes. Two families of human nucleoside transporters (equilibrative nucleoside transporters and concentrative nucleoside transporters) have been extensively studied for several decades. They are widely distributed, from the plasma membrane to membranes of organelles such as mitochondria, and the distribution differs in different tissues. In addition, they have different specificities to nucleoside drugs. The characteristics of equilibrative and concentrative nucleoside transporters affect the therapeutic outcomes achieved with anticancer and antiviral nucleoside drugs. In this review, an overview of the role of mitochondrial and plasma membrane nucleoside transporters in nucleoside drug toxicity is provided. Rational design and therapeutic application of nucleoside analogues are also discussed. © 2007 Informa UK Ltd.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/emten_HK
dc.relation.ispartofExpert Opinion on Drug Metabolism and Toxicologyen_HK
dc.rightsExpert Opinion on Drug Metabolism & Toxicology. Copyright © Informa Healthcare.en_HK
dc.subjectAnticanceren_HK
dc.subjectAntiviralen_HK
dc.subjectMitochondriaen_HK
dc.subjectNucleosideen_HK
dc.subjectToxicityen_HK
dc.subjectTransporteren_HK
dc.titleThe role of mitochondrial and plasma membrane nucleoside transporters in drug toxicityen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1742-5255&volume=3&spage=705&epage=718&date=2007&atitle=The+role+of+mitochondrial+and+plasma+membrane+nucleoside+transporters+in+drug+toxicityen_HK
dc.identifier.emailLeung, GPH: gphleung@hkucc.hku.hken_HK
dc.identifier.authorityLeung, GPH=rp00234en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1517/17425225.3.5.705en_HK
dc.identifier.pmid17916056-
dc.identifier.scopuseid_2-s2.0-38449092117en_HK
dc.identifier.hkuros157510en_HK
dc.identifier.volume3en_HK
dc.identifier.issue5en_HK
dc.identifier.spage705en_HK
dc.identifier.epage718en_HK
dc.identifier.eissn1744-7607-
dc.identifier.isiWOS:000250295400005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLeung, GPH=35963668200en_HK
dc.identifier.scopusauthoridTse, CM=7103295076en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats