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Article: Mucosal nitric oxide is not responsible for the hemodynamic changes induced by nicotine in rat stomachs

TitleMucosal nitric oxide is not responsible for the hemodynamic changes induced by nicotine in rat stomachs
Authors
KeywordsEthanol
Gastric hemodynamics
Gastric lesion
Nicotine
Nitric oxide
Issue Date1996
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/etap
Citation
Environmental Toxicology And Pharmacology, 1996, v. 1 n. 3, p. 167-174 How to Cite?
AbstractIt has been shown that chronic nicotine treatment decreases gastric mucosal blood flow (GMBF). The mechanism for this action is still not defined. In this study, nicotine treatment (5, 25 or 50 μg/ml drinking water) for 10 days dose dependently reduced the GMBF and volume of hemoglobin but increased ethanol-induced gastric damage. These effects were potentiated by N(ω)-nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthase inhibitor, L-arginine but not the D-analog restored the actions of L-NAME, indicating that the selective action of L-NAME. However, the potentiating actions of L-NAME were significantly attenuated in the nicotine-pretreated rats. When the basal mucosal NO synthase (both iNOS and cNOS) activity and its second messenger cyclic GMP levels were measured, no difference was found between the nicotine and the non-nicotine groups. Furthermore, high dose of L-arginine could not reverse the action of nicotine. These findings suggest that the adverse action of chronic nicotine treatment on GMBF and lesion formation is probably mediated through a NO independent mechanism.
Persistent Identifierhttp://hdl.handle.net/10722/80214
ISSN
2015 Impact Factor: 2.187
2015 SCImago Journal Rankings: 0.791
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, Den_HK
dc.contributor.authorQiu, BSen_HK
dc.contributor.authorKo, JKSen_HK
dc.contributor.authorKoo, MWLen_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2010-09-06T08:03:48Z-
dc.date.available2010-09-06T08:03:48Z-
dc.date.issued1996en_HK
dc.identifier.citationEnvironmental Toxicology And Pharmacology, 1996, v. 1 n. 3, p. 167-174en_HK
dc.identifier.issn1382-6689en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80214-
dc.description.abstractIt has been shown that chronic nicotine treatment decreases gastric mucosal blood flow (GMBF). The mechanism for this action is still not defined. In this study, nicotine treatment (5, 25 or 50 μg/ml drinking water) for 10 days dose dependently reduced the GMBF and volume of hemoglobin but increased ethanol-induced gastric damage. These effects were potentiated by N(ω)-nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthase inhibitor, L-arginine but not the D-analog restored the actions of L-NAME, indicating that the selective action of L-NAME. However, the potentiating actions of L-NAME were significantly attenuated in the nicotine-pretreated rats. When the basal mucosal NO synthase (both iNOS and cNOS) activity and its second messenger cyclic GMP levels were measured, no difference was found between the nicotine and the non-nicotine groups. Furthermore, high dose of L-arginine could not reverse the action of nicotine. These findings suggest that the adverse action of chronic nicotine treatment on GMBF and lesion formation is probably mediated through a NO independent mechanism.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/etapen_HK
dc.relation.ispartofEnvironmental Toxicology and Pharmacologyen_HK
dc.rightsEnvironmental Toxicology and Pharmacology. Copyright © Elsevier BV.en_HK
dc.subjectEthanolen_HK
dc.subjectGastric hemodynamicsen_HK
dc.subjectGastric lesionen_HK
dc.subjectNicotineen_HK
dc.subjectNitric oxideen_HK
dc.titleMucosal nitric oxide is not responsible for the hemodynamic changes induced by nicotine in rat stomachsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1382-6689&volume=1&spage=167&epage=174&date=1996&atitle=Mucosal+nitric+oxide+is+not+responsible+for+the+hemodynamic+changes+induced+by+nicotine+in+rat+stomachsen_HK
dc.identifier.emailKoo, MWL: wlkoo@hku.hken_HK
dc.identifier.authorityKoo, MWL=rp00233en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/1382-6689(96)00003-8en_HK
dc.identifier.scopuseid_2-s2.0-0029975620en_HK
dc.identifier.hkuros14985en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029975620&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1en_HK
dc.identifier.issue3en_HK
dc.identifier.spage167en_HK
dc.identifier.epage174en_HK
dc.identifier.isiWOS:A1996UU45600002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridWong, D=36932587600en_HK
dc.identifier.scopusauthoridQiu, BS=7102407334en_HK
dc.identifier.scopusauthoridKo, JKS=7402678571en_HK
dc.identifier.scopusauthoridKoo, MWL=7004550899en_HK
dc.identifier.scopusauthoridCho, CH=7403100461en_HK

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