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Article: A new role of heparin: A polysaccharide for gastrointestinal diseases

TitleA new role of heparin: A polysaccharide for gastrointestinal diseases
Authors
KeywordsGastric ulcer
Heparin
Ulcerative colitis
Issue Date2002
PublisherBirkhaeuser Verlag AG.
Citation
Inflammopharmacology, 2002, v. 10 n. 4-6, p. 365-374 How to Cite?
AbstractHeparin is a highly sulfated glycosaminoglycan found in secretory granules of mast cells. It is known for its anticoagulant activity and used for various coagulation disorders and vascular problems. Recently, more novel actions other than the anticoagulant function have been identified. It was reported to promote gastric ulcer healing and inhibit inflammation in the colon. These actions were shown to be mediated through the increase of expressions and functions of various growth factors, such as basic fibroblast growth factor, epidermal growth factor and insulin-like growth factor. Heparin also stimulated the gastric mucus synthesis via activation of nitric oxide synthase. This article summarizes these actions and reports the potential therapeutic application of heparin on gastric ulcer and ulcerative colitis both in animals and humans.
Persistent Identifierhttp://hdl.handle.net/10722/80206
ISSN
2015 Impact Factor: 2.304
2015 SCImago Journal Rankings: 0.974
References

 

DC FieldValueLanguage
dc.contributor.authorYe, YNen_HK
dc.contributor.authorLi, Yen_HK
dc.contributor.authorKoo, MWLen_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2010-09-06T08:03:42Z-
dc.date.available2010-09-06T08:03:42Z-
dc.date.issued2002en_HK
dc.identifier.citationInflammopharmacology, 2002, v. 10 n. 4-6, p. 365-374en_HK
dc.identifier.issn0925-4692en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80206-
dc.description.abstractHeparin is a highly sulfated glycosaminoglycan found in secretory granules of mast cells. It is known for its anticoagulant activity and used for various coagulation disorders and vascular problems. Recently, more novel actions other than the anticoagulant function have been identified. It was reported to promote gastric ulcer healing and inhibit inflammation in the colon. These actions were shown to be mediated through the increase of expressions and functions of various growth factors, such as basic fibroblast growth factor, epidermal growth factor and insulin-like growth factor. Heparin also stimulated the gastric mucus synthesis via activation of nitric oxide synthase. This article summarizes these actions and reports the potential therapeutic application of heparin on gastric ulcer and ulcerative colitis both in animals and humans.en_HK
dc.languageengen_HK
dc.publisherBirkhaeuser Verlag AG.en_HK
dc.relation.ispartofInflammopharmacologyen_HK
dc.subjectGastric ulceren_HK
dc.subjectHeparinen_HK
dc.subjectUlcerative colitisen_HK
dc.titleA new role of heparin: A polysaccharide for gastrointestinal diseasesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0925-4692&volume=10 No 4-6&spage=365&epage=374&date=2002&atitle=A+new+role+of+heparin:+A+polysaccharide+for+gastrointestinal+diseases+en_HK
dc.identifier.emailKoo, MWL: wlkoo@hku.hken_HK
dc.identifier.authorityKoo, MWL=rp00233en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1163/156856002321544837-
dc.identifier.scopuseid_2-s2.0-0038445109en_HK
dc.identifier.hkuros77987en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038445109&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue4-6en_HK
dc.identifier.spage365en_HK
dc.identifier.epage374en_HK
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridYe, YN=7401627402en_HK
dc.identifier.scopusauthoridLi, Y=54970770000en_HK
dc.identifier.scopusauthoridKoo, MWL=7004550899en_HK
dc.identifier.scopusauthoridCho, CH=7403100461en_HK

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