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Article: Platelet-activating factor enhanced the pressor response of endothelin-1

TitlePlatelet-activating factor enhanced the pressor response of endothelin-1
Authors
KeywordsBlood pressure
Endothelin-1
ETA receptors
Platelet-activating factor
Rats
Issue Date2002
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 2002, v. 40 n. 4, p. 528-532 How to Cite?
AbstractBoth endothelin-1 (ET-1) and platelet-activating factor (PAF) have been suggested to play a role in the regulation of the cardiovascular system. In view of the limited data regarding the interaction between ET-1 and PAF, the hemodynamic effects of ET-1 and PAF, either alone or in combination, were investigated in the current study. Anesthetized male Sprague Dawley rats received bolus intravenous injections of ET-1 (1 and 2 nmol/kg) and/or PAF (0.075, 0.15 and 0.3 nmol/kg). In some experiments, the ETA receptor antagonist, FR-139317 (2.5 or 5 mg/kg), were injected 5 min before the administration of ET-1 or PAF. ET-1 caused a biphasic response consisting of an initial depressor followed by a delayed but sustained pressor response. Injection of PAF to anesthetized rats resulted only in a decrease in arterial blood pressure. Interestingly, the pressor effect of ET-1 was significantly enhanced in the concomitant presence of PAF. Pretreatment with FR-139317 inhibited the magnitude of ET-1-induced hypertension and increased the duration of the depressor action of ET-1. The time-course of PAF-induced decrease of arterial blood pressure was also prolonged in rats pretreated with FR-139317. These data therefore suggested that ETA receptors were activated, either directly or indirectly, by PAF, possibly to facilitate the return of blood pressure to resting level following a depressor response. Thus the activation of ETA receptors by PAF might result in the enhancement of the pressor response of ET-1 observed in the current study.
Persistent Identifierhttp://hdl.handle.net/10722/80201
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, SWSen_HK
dc.contributor.authorMan, GSKen_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2010-09-06T08:03:39Z-
dc.date.available2010-09-06T08:03:39Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 2002, v. 40 n. 4, p. 528-532en_HK
dc.identifier.issn0160-2446en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80201-
dc.description.abstractBoth endothelin-1 (ET-1) and platelet-activating factor (PAF) have been suggested to play a role in the regulation of the cardiovascular system. In view of the limited data regarding the interaction between ET-1 and PAF, the hemodynamic effects of ET-1 and PAF, either alone or in combination, were investigated in the current study. Anesthetized male Sprague Dawley rats received bolus intravenous injections of ET-1 (1 and 2 nmol/kg) and/or PAF (0.075, 0.15 and 0.3 nmol/kg). In some experiments, the ETA receptor antagonist, FR-139317 (2.5 or 5 mg/kg), were injected 5 min before the administration of ET-1 or PAF. ET-1 caused a biphasic response consisting of an initial depressor followed by a delayed but sustained pressor response. Injection of PAF to anesthetized rats resulted only in a decrease in arterial blood pressure. Interestingly, the pressor effect of ET-1 was significantly enhanced in the concomitant presence of PAF. Pretreatment with FR-139317 inhibited the magnitude of ET-1-induced hypertension and increased the duration of the depressor action of ET-1. The time-course of PAF-induced decrease of arterial blood pressure was also prolonged in rats pretreated with FR-139317. These data therefore suggested that ETA receptors were activated, either directly or indirectly, by PAF, possibly to facilitate the return of blood pressure to resting level following a depressor response. Thus the activation of ETA receptors by PAF might result in the enhancement of the pressor response of ET-1 observed in the current study.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_HK
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_HK
dc.rightsJournal of Cardiovascular Pharmacology. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectBlood pressureen_HK
dc.subjectEndothelin-1en_HK
dc.subjectETA receptorsen_HK
dc.subjectPlatelet-activating factoren_HK
dc.subjectRatsen_HK
dc.titlePlatelet-activating factor enhanced the pressor response of endothelin-1en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0160-2446&volume=40&spage=528&epage=532&date=2002&atitle=Platelet-Activating+Factor+Enhanced+the+Pressor+Response+of+Endothelin-1en_HK
dc.identifier.emailLeung, SWS: swsleung@hku.hken_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SWS=rp00235en_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00005344-200210000-00005en_HK
dc.identifier.pmid12352314-
dc.identifier.scopuseid_2-s2.0-0036784874en_HK
dc.identifier.hkuros76249en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036784874&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume40en_HK
dc.identifier.issue4en_HK
dc.identifier.spage528en_HK
dc.identifier.epage532en_HK
dc.identifier.isiWOS:000178253500005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLeung, SWS=24540419500en_HK
dc.identifier.scopusauthoridMan, GSK=7003741547en_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK

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