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Article: Non-genomic vascular actions of female sex hormones: Physiological implications and signalling pathways

TitleNon-genomic vascular actions of female sex hormones: Physiological implications and signalling pathways
Authors
Keywords17β-oestradiol
Coronary heart disease
Endothelium
Hormone replacement therapy
Non-genomic
Vascular reactivity
Issue Date2007
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP
Citation
Clinical And Experimental Pharmacology And Physiology, 2007, v. 34 n. 8, p. 822-826 How to Cite?
Abstract1. Epidemiological studies indicate a lower incidence of coronary heart disease in premenopausal women compared with age-matched men and post-menopausal women. Accumulating evidence suggests that this cardiovascular protection observed in premenopausal women is at least partially attributed to the direct action of oestrogens on the vascular system. 2. Research focused on vascular actions of 17β-oestradiol indicates that this female sex hormone favourably modulates vascular reactivity at physiological concentrations. The vascular actions of 17β-oestradiol appear independent of its genomic actions. Both endothelium-dependent and -independent signalling cascades have been implicated in the vascular effects of 17β-oestradiol. 3. However, clinical trials on hormone-replacement therapy argue against a role of oestrogens in preventing the development of coronary heart disease. Supplementation with oestrogen is also complicated with the increased risk of breast and endometrial cancer. Hence, a better understanding of the vascular actions of 17β-oestradiol will serve to enhance our understanding of its role in coronary heart disease. © 2007 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/80199
ISSN
2012 Impact Factor: 2.16
2015 SCImago Journal Rankings: 0.944
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, SWSen_HK
dc.contributor.authorTeoh, Hen_HK
dc.contributor.authorKeung, Wen_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2010-09-06T08:03:37Z-
dc.date.available2010-09-06T08:03:37Z-
dc.date.issued2007en_HK
dc.identifier.citationClinical And Experimental Pharmacology And Physiology, 2007, v. 34 n. 8, p. 822-826en_HK
dc.identifier.issn0305-1870en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80199-
dc.description.abstract1. Epidemiological studies indicate a lower incidence of coronary heart disease in premenopausal women compared with age-matched men and post-menopausal women. Accumulating evidence suggests that this cardiovascular protection observed in premenopausal women is at least partially attributed to the direct action of oestrogens on the vascular system. 2. Research focused on vascular actions of 17β-oestradiol indicates that this female sex hormone favourably modulates vascular reactivity at physiological concentrations. The vascular actions of 17β-oestradiol appear independent of its genomic actions. Both endothelium-dependent and -independent signalling cascades have been implicated in the vascular effects of 17β-oestradiol. 3. However, clinical trials on hormone-replacement therapy argue against a role of oestrogens in preventing the development of coronary heart disease. Supplementation with oestrogen is also complicated with the increased risk of breast and endometrial cancer. Hence, a better understanding of the vascular actions of 17β-oestradiol will serve to enhance our understanding of its role in coronary heart disease. © 2007 The Authors.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEPen_HK
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_HK
dc.subject17β-oestradiolen_HK
dc.subjectCoronary heart diseaseen_HK
dc.subjectEndotheliumen_HK
dc.subjectHormone replacement therapyen_HK
dc.subjectNon-genomicen_HK
dc.subjectVascular reactivityen_HK
dc.titleNon-genomic vascular actions of female sex hormones: Physiological implications and signalling pathwaysen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0305-1870&volume=34&spage=822&epage=826&date=2007&atitle=Non-genomic+vascular+actions+of+female+sex+hormones:+physiological+implications+and+signalling+pathways.en_HK
dc.identifier.emailLeung, SWS: swsleung@hku.hken_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SWS=rp00235en_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1681.2007.04686.xen_HK
dc.identifier.pmid17600565-
dc.identifier.scopuseid_2-s2.0-34347348070en_HK
dc.identifier.hkuros130667en_HK
dc.identifier.hkuros214407-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34347348070&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue8en_HK
dc.identifier.spage822en_HK
dc.identifier.epage826en_HK
dc.identifier.isiWOS:000247575500023-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridLeung, SWS=24540419500en_HK
dc.identifier.scopusauthoridTeoh, H=7003816542en_HK
dc.identifier.scopusauthoridKeung, W=19337708900en_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK
dc.identifier.citeulike1421073-

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