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Article: Antiangiogenic effect of a highly selective cyclooxygenase-2 inhibitor on gastric ulcer healing in rats

TitleAntiangiogenic effect of a highly selective cyclooxygenase-2 inhibitor on gastric ulcer healing in rats
Authors
KeywordsAngiogenesis
Basic fibroblast growth factor
Cyclooxygenase
Gastric ulcer
Rofecoxib
Issue Date2002
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/taap
Citation
Toxicology And Applied Pharmacology, 2002, v. 183 n. 1, p. 41-45 How to Cite?
AbstractSelective cyclooxygenase-2 (COX-2) inhibitors have been shown to produce fewer gastrointestinal adverse reactions when compared with conventional nonselective nonsteroidal anti-inflammatory drugs and they suppress angiogenesis in tumors. The purpose of the present study was to investigate the effects of highly selective COX-2 inhibitor on angiogenesis and protein expression of angiogenic factor during gastric ulcer healing. Gastric ulcers were induced in male Sprague-Dawley rats by a luminal application of acetic acid solution. Rofecoxib, a selective COX-2 inhibitor, was administered at a dose of 10 mg/kg/day by gastric intubation for 14 successive days. The ulcer size was measured at different time intervals after ulcer induction. The microvessels that were immunohistologically positive for von Willebrand factor within the ulcer bed were counted. The protein levels of basic fibroblast growth factor (bFGF) and concentration of prostaglandin E2 (PGE2) in the ulcer tissues were analyzed with Western blotting and immunoassay methods, respectively. The results demonstrated that rofecoxib treatment significantly increased the ulcer size at days 6, 10, and 15. It decreased the number of microvessels, bFGF protein expression, and PGE2 level in the ulcer base at day 6. The findings that highly selective COX-2 inhibitor delayed ulcer healing in rats and impaired angiogenesis in the ulcer base raise cautions regarding the use of COX-2 inhibitors in patients with gastric ulcers. © 2002 Elsevier Science (USA).
Persistent Identifierhttp://hdl.handle.net/10722/80197
ISSN
2015 Impact Factor: 3.847
2015 SCImago Journal Rankings: 1.593
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuo, JSen_HK
dc.contributor.authorCho, CHen_HK
dc.contributor.authorLam Liu, ESen_HK
dc.contributor.authorChoy, HTen_HK
dc.contributor.authorWang, JYen_HK
dc.contributor.authorLeung Koo, MWen_HK
dc.date.accessioned2010-09-06T08:03:36Z-
dc.date.available2010-09-06T08:03:36Z-
dc.date.issued2002en_HK
dc.identifier.citationToxicology And Applied Pharmacology, 2002, v. 183 n. 1, p. 41-45en_HK
dc.identifier.issn0041-008Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/80197-
dc.description.abstractSelective cyclooxygenase-2 (COX-2) inhibitors have been shown to produce fewer gastrointestinal adverse reactions when compared with conventional nonselective nonsteroidal anti-inflammatory drugs and they suppress angiogenesis in tumors. The purpose of the present study was to investigate the effects of highly selective COX-2 inhibitor on angiogenesis and protein expression of angiogenic factor during gastric ulcer healing. Gastric ulcers were induced in male Sprague-Dawley rats by a luminal application of acetic acid solution. Rofecoxib, a selective COX-2 inhibitor, was administered at a dose of 10 mg/kg/day by gastric intubation for 14 successive days. The ulcer size was measured at different time intervals after ulcer induction. The microvessels that were immunohistologically positive for von Willebrand factor within the ulcer bed were counted. The protein levels of basic fibroblast growth factor (bFGF) and concentration of prostaglandin E2 (PGE2) in the ulcer tissues were analyzed with Western blotting and immunoassay methods, respectively. The results demonstrated that rofecoxib treatment significantly increased the ulcer size at days 6, 10, and 15. It decreased the number of microvessels, bFGF protein expression, and PGE2 level in the ulcer base at day 6. The findings that highly selective COX-2 inhibitor delayed ulcer healing in rats and impaired angiogenesis in the ulcer base raise cautions regarding the use of COX-2 inhibitors in patients with gastric ulcers. © 2002 Elsevier Science (USA).en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/taapen_HK
dc.relation.ispartofToxicology and Applied Pharmacologyen_HK
dc.subjectAngiogenesisen_HK
dc.subjectBasic fibroblast growth factoren_HK
dc.subjectCyclooxygenaseen_HK
dc.subjectGastric ulceren_HK
dc.subjectRofecoxiben_HK
dc.titleAntiangiogenic effect of a highly selective cyclooxygenase-2 inhibitor on gastric ulcer healing in ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0041-008X&volume=183&spage=41&epage=45&date=2002&atitle=Antiangiogenic+effect+of+a+highly+selective+cyclooxygenase-2+inhibitor+on+gastric+ulcer+healing+in+ratsen_HK
dc.identifier.emailLeung Koo, MW: wlkoo@hku.hken_HK
dc.identifier.authorityLeung Koo, MW=rp00233en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1006/taap.2002.9457en_HK
dc.identifier.pmid12217640-
dc.identifier.scopuseid_2-s2.0-0036382867en_HK
dc.identifier.hkuros73763en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036382867&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume183en_HK
dc.identifier.issue1en_HK
dc.identifier.spage41en_HK
dc.identifier.epage45en_HK
dc.identifier.isiWOS:000177879700004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGuo, JS=7404488815en_HK
dc.identifier.scopusauthoridCho, CH=7403100461en_HK
dc.identifier.scopusauthoridLam Liu, ES=15767589000en_HK
dc.identifier.scopusauthoridChoy, HT=15767178500en_HK
dc.identifier.scopusauthoridWang, JY=8071004900en_HK
dc.identifier.scopusauthoridLeung Koo, MW=7004550899en_HK

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