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Article: Effect of postmenopausal hormone replacement therapy on lipoprotein and homocysteine levels in Chinese women

TitleEffect of postmenopausal hormone replacement therapy on lipoprotein and homocysteine levels in Chinese women
Authors
KeywordsEstrogen
Homocysteine
Hormone replacement therapy
Lip proteins
Progestin
Issue Date2001
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177
Citation
Molecular And Cellular Biochemistry, 2001, v. 225 n. 1-2, p. 129-134 How to Cite?
AbstractEpidemiological studies have revealed that postmenopausal estrogen replacement therapy results in a marked reduction in the risk for cardiovascular diseases. In the present study, we evaluated plasma lipoprotein profile as well as homocysteine levels in 145 postmenopausal and premenopausal Chinese women living in Hong Kong. We also investigated the effect of hormone-replacement therapy (HRT) with estrogen or estrogen combined with progestin on plasma lipoprotein profile and homocysteine concentrations in those individuals. Postmenopausal women displayed significantly higher plasma levels of total cholesterol, LDL-cholesterol and apoB as well as higher plasma homocysteine levels than that of premenopausal women. HRT with either estrogen (17β-estradiol or conjugated equine estrogen) alone or estrogen combined with progestin for 3.5-4.5 years significantly improved the lipoprotein profile in postmenopausal women by decreasing the levels of total cholesterol (12-20% reduction), LDL-cholesterol (26-29% reduction) and apoB (21-25% reduction). In women treated with 17β-estradiol or conjugated equine estrogens their plasma levels of apoAI were significantly elevated (18% elevation) as compared to non-users. HRT also reduced plasma concentrations of homocysteine (13-15% reduction). In conclusion, we found that long-term HRT was associated with improvement in plasma lipoprotein profile and a reduction in homocysteine concentration in postmenopausal women. These results support the notion that the improvement of lipoprotein profile and a reduction in homocysteine concentration may contribute to the beneficial effect of HRT on cardiovascular risk.
Persistent Identifierhttp://hdl.handle.net/10722/80192
ISSN
2015 Impact Factor: 2.613
2015 SCImago Journal Rankings: 1.019
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMan, RYKen_HK
dc.contributor.authorTing, LKFen_HK
dc.contributor.authorFan, Sen_HK
dc.contributor.authorLau, MMHen_HK
dc.contributor.authorSiow, YLen_HK
dc.contributor.authorChung, YHen_HK
dc.contributor.authorK, Oen_HK
dc.date.accessioned2010-09-06T08:03:32Z-
dc.date.available2010-09-06T08:03:32Z-
dc.date.issued2001en_HK
dc.identifier.citationMolecular And Cellular Biochemistry, 2001, v. 225 n. 1-2, p. 129-134en_HK
dc.identifier.issn0300-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80192-
dc.description.abstractEpidemiological studies have revealed that postmenopausal estrogen replacement therapy results in a marked reduction in the risk for cardiovascular diseases. In the present study, we evaluated plasma lipoprotein profile as well as homocysteine levels in 145 postmenopausal and premenopausal Chinese women living in Hong Kong. We also investigated the effect of hormone-replacement therapy (HRT) with estrogen or estrogen combined with progestin on plasma lipoprotein profile and homocysteine concentrations in those individuals. Postmenopausal women displayed significantly higher plasma levels of total cholesterol, LDL-cholesterol and apoB as well as higher plasma homocysteine levels than that of premenopausal women. HRT with either estrogen (17β-estradiol or conjugated equine estrogen) alone or estrogen combined with progestin for 3.5-4.5 years significantly improved the lipoprotein profile in postmenopausal women by decreasing the levels of total cholesterol (12-20% reduction), LDL-cholesterol (26-29% reduction) and apoB (21-25% reduction). In women treated with 17β-estradiol or conjugated equine estrogens their plasma levels of apoAI were significantly elevated (18% elevation) as compared to non-users. HRT also reduced plasma concentrations of homocysteine (13-15% reduction). In conclusion, we found that long-term HRT was associated with improvement in plasma lipoprotein profile and a reduction in homocysteine concentration in postmenopausal women. These results support the notion that the improvement of lipoprotein profile and a reduction in homocysteine concentration may contribute to the beneficial effect of HRT on cardiovascular risk.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177en_HK
dc.relation.ispartofMolecular and Cellular Biochemistryen_HK
dc.subjectEstrogenen_HK
dc.subjectHomocysteineen_HK
dc.subjectHormone replacement therapyen_HK
dc.subjectLip proteinsen_HK
dc.subjectProgestinen_HK
dc.titleEffect of postmenopausal hormone replacement therapy on lipoprotein and homocysteine levels in Chinese womenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-8177&volume=225&spage=129&epage=34&date=2001&atitle=Effect+of+postmenopausal+hormone+replacement+therapy+on+lipoprotein+and+homocysteine+levels+in+Chinese+womenen_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1023/A:1017405507246en_HK
dc.identifier.pmid11716354en_HK
dc.identifier.scopuseid_2-s2.0-0034750734en_HK
dc.identifier.hkuros73805en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034750734&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume225en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage129en_HK
dc.identifier.epage134en_HK
dc.identifier.isiWOS:000171402500015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK
dc.identifier.scopusauthoridTing, LKF=7102388977en_HK
dc.identifier.scopusauthoridFan, S=11639038000en_HK
dc.identifier.scopusauthoridLau, MMH=7102344977en_HK
dc.identifier.scopusauthoridSiow, YL=7003336463en_HK
dc.identifier.scopusauthoridChung, YH=7404388012en_HK
dc.identifier.scopusauthoridK, O=24174711400en_HK

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