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Article: Bone marrow transplantation for fanconi anaemia using a fludarabine-based preparative regimen with CD34+ cell selection

TitleBone marrow transplantation for fanconi anaemia using a fludarabine-based preparative regimen with CD34+ cell selection
Authors
KeywordsAplastic anaemia
Bone marrow transplantation
Fanconi anaemia
Issue Date2006
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Hong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 39-44 How to Cite?
AbstractFanconi anaemia (FA) is an important cause of inherited aplastic anemia in childhood because of its relatively high frequency of occurrence, the implication for different management, and the need for genetic counselling. The common manifestations are congenital physical abnormalities, marrow failure, and predisposition to development of cancers. Bone marrow transplantation has been used to treat marrow failure for FA patients but they are at increased risks of transplant related toxicities and graft versus host disease. We report two children with FA who were treated successfully with matched sibling bone marrow transplantation using a new fludarabine-based conditioning regimen without irradiation. The stem cell source was from marrow which was infused after positive selection of CD34+ cells. Both patients had haematological recovery and no major post-transplant complications occurred. One achieved full donor chimerism and stable mixed chimerism was present in another. This regimen appears to be effective and can prevent FA patients from major transplant related complications.
Persistent Identifierhttp://hdl.handle.net/10722/80179
ISSN
2015 Impact Factor: 0.194
2015 SCImago Journal Rankings: 0.123
References

 

DC FieldValueLanguage
dc.contributor.authorHa, SYen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorChiang, AKSen_HK
dc.contributor.authorLee, ACWen_HK
dc.contributor.authorLee, TLen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-06T08:03:18Z-
dc.date.available2010-09-06T08:03:18Z-
dc.date.issued2006en_HK
dc.identifier.citationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 39-44en_HK
dc.identifier.issn1013-9923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80179-
dc.description.abstractFanconi anaemia (FA) is an important cause of inherited aplastic anemia in childhood because of its relatively high frequency of occurrence, the implication for different management, and the need for genetic counselling. The common manifestations are congenital physical abnormalities, marrow failure, and predisposition to development of cancers. Bone marrow transplantation has been used to treat marrow failure for FA patients but they are at increased risks of transplant related toxicities and graft versus host disease. We report two children with FA who were treated successfully with matched sibling bone marrow transplantation using a new fludarabine-based conditioning regimen without irradiation. The stem cell source was from marrow which was infused after positive selection of CD34+ cells. Both patients had haematological recovery and no major post-transplant complications occurred. One achieved full donor chimerism and stable mixed chimerism was present in another. This regimen appears to be effective and can prevent FA patients from major transplant related complications.en_HK
dc.languageengen_HK
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.aspen_HK
dc.relation.ispartofHong Kong Journal of Paediatricsen_HK
dc.subjectAplastic anaemiaen_HK
dc.subjectBone marrow transplantationen_HK
dc.subjectFanconi anaemiaen_HK
dc.titleBone marrow transplantation for fanconi anaemia using a fludarabine-based preparative regimen with CD34+ cell selectionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9923&volume=11&spage=39&epage=44&date=2006&atitle=Bone+Marrow+Transplantation+for+Fanconi+Anaemia+Using+a+Fludarabine-based+Preparative+Regimen+with+CD34++Cell+Selectionen_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailChiang, AKS:chiangak@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityChiang, AKS=rp00403en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.scopuseid_2-s2.0-31344443583en_HK
dc.identifier.hkuros114557en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-31344443583&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue1en_HK
dc.identifier.spage39en_HK
dc.identifier.epage44en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridChiang, AKS=7101623534en_HK
dc.identifier.scopusauthoridLee, ACW=7405631431en_HK
dc.identifier.scopusauthoridLee, TL=24483772800en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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