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Article: Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley

TitleResponse of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley
Authors
KeywordsBarley
Ganoderma lucidum
Human dendritic cell
Immunomodulation
Polysaccharides
Issue Date2007
PublisherOxford University Press. The Journal's web site is located at http://intimm.oxfordjournals.org/
Citation
International Immunology, 2007, v. 19 n. 7, p. 891-899 How to Cite?
AbstractPolysaccharides derived from fungi and plants have been increasingly used as dietary supplement with therapeutic intention for cancer. However, whether these polysaccharides from different sources and structures can elicit similar immunological effects remain unknown. This study aims to investigate and compare the effects of selected groups of purified and crude polysaccharides on human dendritic cells (DCs), the most potent antigen-presenting cells. The selected polysaccharides were from Ganoderma lucidum [(GL) Lingzhi, Reishi], a medicinal mushroom commonly used by oriental; and barley glucan, a purified polysaccharide with known in vivo immunomodulating effect. We found that purified polysaccharides from GL mycelium could induce human PBMC proliferation and phenotypic and functional maturation of DCs with significant IL-12 and IL-10 production. Polysaccharides of GL spore and barley were both rather weak immunostimulator in vitro. In general, all these polysaccharides did not polarize T cells into either T1 or Th2 or regulatory T cells, except for crude spore polysaccharides-treated DCs which could suppress T cell proliferation with IL-10 production. This study revealed the polysaccharides of different sources have different immune potency and effect on human immune cells including DCs. Our study also provides a reproducible biological platform for comparing the potential therapeutic effects of different herbal-derived polysaccharides in the future. © The Japanese Society for Immunology. 2007. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/80161
ISSN
2015 Impact Factor: 3.031
2015 SCImago Journal Rankings: 1.613
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, WKen_HK
dc.contributor.authorLaw, HKLen_HK
dc.contributor.authorLin, ZBen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorChan, GCFen_HK
dc.date.accessioned2010-09-06T08:03:06Z-
dc.date.available2010-09-06T08:03:06Z-
dc.date.issued2007en_HK
dc.identifier.citationInternational Immunology, 2007, v. 19 n. 7, p. 891-899en_HK
dc.identifier.issn0953-8178en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80161-
dc.description.abstractPolysaccharides derived from fungi and plants have been increasingly used as dietary supplement with therapeutic intention for cancer. However, whether these polysaccharides from different sources and structures can elicit similar immunological effects remain unknown. This study aims to investigate and compare the effects of selected groups of purified and crude polysaccharides on human dendritic cells (DCs), the most potent antigen-presenting cells. The selected polysaccharides were from Ganoderma lucidum [(GL) Lingzhi, Reishi], a medicinal mushroom commonly used by oriental; and barley glucan, a purified polysaccharide with known in vivo immunomodulating effect. We found that purified polysaccharides from GL mycelium could induce human PBMC proliferation and phenotypic and functional maturation of DCs with significant IL-12 and IL-10 production. Polysaccharides of GL spore and barley were both rather weak immunostimulator in vitro. In general, all these polysaccharides did not polarize T cells into either T1 or Th2 or regulatory T cells, except for crude spore polysaccharides-treated DCs which could suppress T cell proliferation with IL-10 production. This study revealed the polysaccharides of different sources have different immune potency and effect on human immune cells including DCs. Our study also provides a reproducible biological platform for comparing the potential therapeutic effects of different herbal-derived polysaccharides in the future. © The Japanese Society for Immunology. 2007. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://intimm.oxfordjournals.org/en_HK
dc.relation.ispartofInternational Immunologyen_HK
dc.rightsInternational Immunology. Copyright © Oxford University Press.en_HK
dc.subjectBarleyen_HK
dc.subjectGanoderma lucidumen_HK
dc.subjectHuman dendritic cellen_HK
dc.subjectImmunomodulationen_HK
dc.subjectPolysaccharidesen_HK
dc.titleResponse of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barleyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0953-8178&volume=19 &issue=7&spage=891&epage=899&date=2007&atitle=Response+of+human+dendritic+cells+to+different+immunomodulatory+polysaccharides+derived+from+mushroom+and+barleyen_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/intimm/dxm061en_HK
dc.identifier.pmid17606977-
dc.identifier.scopuseid_2-s2.0-34547838395en_HK
dc.identifier.hkuros129296en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547838395&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue7en_HK
dc.identifier.spage891en_HK
dc.identifier.epage899en_HK
dc.identifier.isiWOS:000249127900008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, WK=35080149500en_HK
dc.identifier.scopusauthoridLaw, HKL=7101939394en_HK
dc.identifier.scopusauthoridLin, ZB=7404230065en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK

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