File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Herpes zoster in juvenile-onset systemic lupus erythematosus: Incidence, clinical characteristics and risk factors

TitleHerpes zoster in juvenile-onset systemic lupus erythematosus: Incidence, clinical characteristics and risk factors
Authors
KeywordsChildren
Herpes zoster
Juvenile-onset
Systemic lupus erythematosus
Issue Date2006
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pidj.com
Citation
Pediatric Infectious Disease Journal, 2006, v. 25 n. 8, p. 728-732 How to Cite?
AbstractBACKGROUND: Herpes zoster (HZ) is common in systemic lupus erythematosus (SLE) patients, but its clinical features and risk factors in juvenile-onset SLE have not been well described before. METHODS: A retrospective review of the clinical course and infections in pediatric SLE patients managed in our institution from 1988-2004 was performed. Clinical characteristics and potential risk factors for HZ were analyzed. RESULTS: Forty-nine children with SLE were identified. Nineteen episodes of HZ were recorded in 15 patients, and 2 of them had recurrent HZ. The incidence rate was 58.7 episodes/1000 patient-years. No patient had disseminated HZ, postherpetic neuralgia, or cutaneous scarring, and no death was attributed to HZ. Most (63.2%) HZ occurred within 6 months from onset of SLE or disease flare-up. There was no significant difference in age of onset of SLE, gender, disease duration, use of high dose steroid, or other immunosuppressive agents in patients with and without HZ. Patients with HZ were more likely to have prior or concurrent lupus nephritis (86.7%) than those without HZ (58.5%) (P = 0.096). Occurrence of other major infections was also significantly more common in those who had HZ (80.0%) than those without (32.3%) (P = 0.006). CONCLUSIONS: Herpes zoster was common in juvenile-onset SLE patients. Most were benign, without systemic dissemination and postherpetic neuralgia. SLE patients with renal involvement and heightened lupus activity were at greater risk of having HZ. Those with HZ were also more likely to have other major infections during their disease course. Copyright © 2006 by Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/80159
ISSN
2015 Impact Factor: 2.587
2015 SCImago Journal Rankings: 1.416
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, PPWen_HK
dc.contributor.authorLee, TLen_HK
dc.contributor.authorHokKung Ho, Men_HK
dc.contributor.authorWong, WHSen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-06T08:03:05Z-
dc.date.available2010-09-06T08:03:05Z-
dc.date.issued2006en_HK
dc.identifier.citationPediatric Infectious Disease Journal, 2006, v. 25 n. 8, p. 728-732en_HK
dc.identifier.issn0891-3668en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80159-
dc.description.abstractBACKGROUND: Herpes zoster (HZ) is common in systemic lupus erythematosus (SLE) patients, but its clinical features and risk factors in juvenile-onset SLE have not been well described before. METHODS: A retrospective review of the clinical course and infections in pediatric SLE patients managed in our institution from 1988-2004 was performed. Clinical characteristics and potential risk factors for HZ were analyzed. RESULTS: Forty-nine children with SLE were identified. Nineteen episodes of HZ were recorded in 15 patients, and 2 of them had recurrent HZ. The incidence rate was 58.7 episodes/1000 patient-years. No patient had disseminated HZ, postherpetic neuralgia, or cutaneous scarring, and no death was attributed to HZ. Most (63.2%) HZ occurred within 6 months from onset of SLE or disease flare-up. There was no significant difference in age of onset of SLE, gender, disease duration, use of high dose steroid, or other immunosuppressive agents in patients with and without HZ. Patients with HZ were more likely to have prior or concurrent lupus nephritis (86.7%) than those without HZ (58.5%) (P = 0.096). Occurrence of other major infections was also significantly more common in those who had HZ (80.0%) than those without (32.3%) (P = 0.006). CONCLUSIONS: Herpes zoster was common in juvenile-onset SLE patients. Most were benign, without systemic dissemination and postherpetic neuralgia. SLE patients with renal involvement and heightened lupus activity were at greater risk of having HZ. Those with HZ were also more likely to have other major infections during their disease course. Copyright © 2006 by Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pidj.comen_HK
dc.relation.ispartofPediatric Infectious Disease Journalen_HK
dc.rightsThe Pediatric Infectious Disease Journal. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectChildrenen_HK
dc.subjectHerpes zosteren_HK
dc.subjectJuvenile-onseten_HK
dc.subjectSystemic lupus erythematosusen_HK
dc.titleHerpes zoster in juvenile-onset systemic lupus erythematosus: Incidence, clinical characteristics and risk factorsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0891-3668&volume=25&spage=728&epage=732&date=2006&atitle=Herpes+Zoster+in+Juvenile-Onset+Systemic+Lupus+Erythematosusen_HK
dc.identifier.emailLee, PPW:ppwlee@hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityLee, PPW=rp00462en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/01.inf.0000226841.03751.1fen_HK
dc.identifier.pmid16874173-
dc.identifier.scopuseid_2-s2.0-33746743076en_HK
dc.identifier.hkuros120563en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746743076&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue8en_HK
dc.identifier.spage728en_HK
dc.identifier.epage732en_HK
dc.identifier.isiWOS:000239697000011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLee, PPW=14048822200en_HK
dc.identifier.scopusauthoridLee, TL=24483772800en_HK
dc.identifier.scopusauthoridHokKung Ho, M=14055825300en_HK
dc.identifier.scopusauthoridWong, WHS=13310222200en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats