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Article: Linear growth in early treated children with congenital hypothyroidism

TitleLinear growth in early treated children with congenital hypothyroidism
Authors
Issue Date1997
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1328-8067&site=1
Citation
Acta Paediatrica, International Journal Of Paediatrics, 1997, v. 86 n. 5, p. 479-483 How to Cite?
AbstractLength/height was studied from birth to 6 years of age in 103 children with congenital hypothyroidism identified by the Norwegian or Swedish screening programs. We used the 'infancy childhood-puberty (ICP) growth model'. This model describes normal linear growth during the first 3 years of life by an infancy component with the addition of a childhood component, the latter acting from the second half of the first year. In comparison with reference children, children with hypothyroidism had reduced growth from 6 to 12 months, and increased growth after 12 months of age. Mean onset of the childhood component of growth was delayed from 8.1 months (SD 1.9) to 10.4 months (SD 2.2) in girls, and from 8.9 months (SD 2.0) to 11.0 months (SD 2.1) in boys. Age at onset of the childhood component was correlated with age at start of treatment (r=0.24), and in children with more severe hypothyroidism (pretreatment serum thyroxine <40 nmol/l) inversely correlated with the L-thyroxine dose at start of treatment (r = -0.40). Change in height standard deviation score from 1 to 3 years of age was correlated with the serum thyroxine concentration at age 1 year (r = 0.30). The delay in the onset of the childhood component of growth and the association with age at start of treatment and initial (L)-thyroxine dose indicate that thyroid hormones during the first months of life are essential for normal onset of the childhood component of growth, which otherwise is assumed to be growth hormone dependent.
Persistent Identifierhttp://hdl.handle.net/10722/80142
ISSN
2015 Impact Factor: 1.647
2015 SCImago Journal Rankings: 0.794
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHeyerdahl, Sen_HK
dc.contributor.authorIlicki, Aen_HK
dc.contributor.authorKarlberg, Jen_HK
dc.contributor.authorKase, BFen_HK
dc.contributor.authorLarsson, Aen_HK
dc.date.accessioned2010-09-06T08:02:53Z-
dc.date.available2010-09-06T08:02:53Z-
dc.date.issued1997en_HK
dc.identifier.citationActa Paediatrica, International Journal Of Paediatrics, 1997, v. 86 n. 5, p. 479-483en_HK
dc.identifier.issn0803-5253en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80142-
dc.description.abstractLength/height was studied from birth to 6 years of age in 103 children with congenital hypothyroidism identified by the Norwegian or Swedish screening programs. We used the 'infancy childhood-puberty (ICP) growth model'. This model describes normal linear growth during the first 3 years of life by an infancy component with the addition of a childhood component, the latter acting from the second half of the first year. In comparison with reference children, children with hypothyroidism had reduced growth from 6 to 12 months, and increased growth after 12 months of age. Mean onset of the childhood component of growth was delayed from 8.1 months (SD 1.9) to 10.4 months (SD 2.2) in girls, and from 8.9 months (SD 2.0) to 11.0 months (SD 2.1) in boys. Age at onset of the childhood component was correlated with age at start of treatment (r=0.24), and in children with more severe hypothyroidism (pretreatment serum thyroxine <40 nmol/l) inversely correlated with the L-thyroxine dose at start of treatment (r = -0.40). Change in height standard deviation score from 1 to 3 years of age was correlated with the serum thyroxine concentration at age 1 year (r = 0.30). The delay in the onset of the childhood component of growth and the association with age at start of treatment and initial (L)-thyroxine dose indicate that thyroid hormones during the first months of life are essential for normal onset of the childhood component of growth, which otherwise is assumed to be growth hormone dependent.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1328-8067&site=1en_HK
dc.relation.ispartofActa Paediatrica, International Journal of Paediatricsen_HK
dc.titleLinear growth in early treated children with congenital hypothyroidismen_HK
dc.typeArticleen_HK
dc.identifier.emailKarlberg, J: jpekarl@hkucc.hku.hken_HK
dc.identifier.authorityKarlberg, J=rp00400en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9183486-
dc.identifier.scopuseid_2-s2.0-0030958695en_HK
dc.identifier.hkuros22716en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030958695&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume86en_HK
dc.identifier.issue5en_HK
dc.identifier.spage479en_HK
dc.identifier.epage483en_HK
dc.identifier.isiWOS:A1997XC12200009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHeyerdahl, S=6701829987en_HK
dc.identifier.scopusauthoridIlicki, A=6602275222en_HK
dc.identifier.scopusauthoridKarlberg, J=7005218406en_HK
dc.identifier.scopusauthoridKase, BF=7003992938en_HK
dc.identifier.scopusauthoridLarsson, A=7201419939en_HK

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