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Article: Perinatal hypoxia-/ischemia-induced endothelin-1 mRNA in astrocyte-like and endothelial cells

TitlePerinatal hypoxia-/ischemia-induced endothelin-1 mRNA in astrocyte-like and endothelial cells
Authors
KeywordsBrain injury
Cortex
Glia
Hippocampus
Mouse
Neurodegeneration
Issue Date2001
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 2001, v. 12 n. 10, p. 2265-2270 How to Cite?
AbstractUnder pathological conditions in the adult CNS, such as ischemia, subarachnoid hemorrhage and Alzheimer's disease, endothelin (ET)-1- and -3-like immunoreactivities are elevated in astrocytes of the injured adult brain. However, it is not clear whether this is due to increased synthesis or increased binding of ET-1. Further, it is not known whether ET-1 expression is altered in the perinatal brain after cerebral hypoxia/ischemia (H/I). Here, we determined the sites of ET-1 expression in perinatal mouse brain after H/I injury by in situ hybridization using a probe specific for the ET-1 gene. Astrocyte-like cells, which do not normally express ET-1 mRNA, showed high levels of ET-I mRNA expression. Endothelial cells of the capillaries and small vessels also showed an increased level of ET-1 mRNA. Our data suggest that ET-1 mRNA levels in the astrocyte-like cells and vascular endothelial cells are dynamically regulated by ischemia and may participate in perinatal ischemia-relatecl neural damage. © 2001 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/80138
ISSN
2015 Impact Factor: 1.343
2015 SCImago Journal Rankings: 0.783
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsang, MCSen_HK
dc.contributor.authorLo, ACYen_HK
dc.contributor.authorPik To Cheungen_HK
dc.contributor.authorChung, SSMen_HK
dc.contributor.authorChung, SKen_HK
dc.date.accessioned2010-09-06T08:02:51Z-
dc.date.available2010-09-06T08:02:51Z-
dc.date.issued2001en_HK
dc.identifier.citationNeuroreport, 2001, v. 12 n. 10, p. 2265-2270en_HK
dc.identifier.issn0959-4965en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80138-
dc.description.abstractUnder pathological conditions in the adult CNS, such as ischemia, subarachnoid hemorrhage and Alzheimer's disease, endothelin (ET)-1- and -3-like immunoreactivities are elevated in astrocytes of the injured adult brain. However, it is not clear whether this is due to increased synthesis or increased binding of ET-1. Further, it is not known whether ET-1 expression is altered in the perinatal brain after cerebral hypoxia/ischemia (H/I). Here, we determined the sites of ET-1 expression in perinatal mouse brain after H/I injury by in situ hybridization using a probe specific for the ET-1 gene. Astrocyte-like cells, which do not normally express ET-1 mRNA, showed high levels of ET-I mRNA expression. Endothelial cells of the capillaries and small vessels also showed an increased level of ET-1 mRNA. Our data suggest that ET-1 mRNA levels in the astrocyte-like cells and vascular endothelial cells are dynamically regulated by ischemia and may participate in perinatal ischemia-relatecl neural damage. © 2001 Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_HK
dc.relation.ispartofNeuroReporten_HK
dc.rightsNeuroReport. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectBrain injuryen_HK
dc.subjectCortexen_HK
dc.subjectGliaen_HK
dc.subjectHippocampusen_HK
dc.subjectMouseen_HK
dc.subjectNeurodegenerationen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnimals, Newborn - metabolismen_HK
dc.subject.meshAstrocytes - metabolismen_HK
dc.subject.meshBrain - cytology - metabolismen_HK
dc.subject.meshBrain Chemistry - genetics - physiologyen_HK
dc.subject.meshCell Death - physiologyen_HK
dc.subject.meshEndothelin-1 - biosynthesis - geneticsen_HK
dc.subject.meshEndothelium, Vascular - cytology - metabolismen_HK
dc.subject.meshHypoxia-Ischemia, Brain - metabolismen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred C57BLen_HK
dc.subject.meshRNA, Messenger - biosynthesisen_HK
dc.titlePerinatal hypoxia-/ischemia-induced endothelin-1 mRNA in astrocyte-like and endothelial cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0959-4965&volume=12&issue=10&spage=2265&epage=2270&date=2001&atitle=Perinatal+hypoxia-/ischemia-induced+endothelin-1+mRNA+in+astrocyte-like+and+endothelial+cellsen_HK
dc.identifier.emailLo, ACY: amylo@hkucc.hku.hken_HK
dc.identifier.emailPik To Cheung: ptcheung@hku.hken_HK
dc.identifier.emailChung, SSM: smchung@hkucc.hku.hken_HK
dc.identifier.emailChung, SK: skchung@hkucc.hku.hken_HK
dc.identifier.authorityLo, ACY=rp00425en_HK
dc.identifier.authorityPik To Cheung=rp00351en_HK
dc.identifier.authorityChung, SSM=rp00376en_HK
dc.identifier.authorityChung, SK=rp00381en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11447347-
dc.identifier.scopuseid_2-s2.0-0035919751en_HK
dc.identifier.hkuros61499en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035919751&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue10en_HK
dc.identifier.spage2265en_HK
dc.identifier.epage2270en_HK
dc.identifier.isiWOS:000169809200045-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTsang, MCS=9239694300en_HK
dc.identifier.scopusauthoridLo, ACY=7102780640en_HK
dc.identifier.scopusauthoridPik To Cheung=7202595465en_HK
dc.identifier.scopusauthoridChung, SSM=14120761600en_HK
dc.identifier.scopusauthoridChung, SK=7404292976en_HK

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