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Article: Juvenile pernicious anaemia in association with vitiligo, selective IgA deficiency, defective interleukin 12 production and T cell dysfunction

TitleJuvenile pernicious anaemia in association with vitiligo, selective IgA deficiency, defective interleukin 12 production and T cell dysfunction
Authors
KeywordsInterleukin 12
Juvenile pernicious anaemia
Selective IgA deficiency
T cell dysfunction
Vitiligo
Issue Date2006
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Hong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 59-63 How to Cite?
AbstractThe coexistence of juvenile pernicious anaemia, vitiligo and selective IgA deficiency in a Southern Chinese boy stimulated a comprehensive work-up of his immune functions. He was found to have an imbalance of T-helper cell (CD4+) and T-suppressor cell (CD8+) activity, leading to low B cell response in vitro to pokeweed-mitogen in production of IgA. Interleukin 12 production in response to various mitogens was also deficient. These abnormalities persisted despite effective vitamin B12 treatment. We speculate that the defective immunoregulatory environment is an intrinsic defect rather than an acquired phenomenon due to vitamin B12 deficiency, which may play an important role in the pathogenesis of juvenile pernicious anaemia.
Persistent Identifierhttp://hdl.handle.net/10722/80126
ISSN
2015 Impact Factor: 0.194
2015 SCImago Journal Rankings: 0.123
References

 

DC FieldValueLanguage
dc.contributor.authorHo, MHKen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorJones, BMen_HK
dc.contributor.authorLee, TLen_HK
dc.contributor.authorChiang, AKSen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-06T08:02:42Z-
dc.date.available2010-09-06T08:02:42Z-
dc.date.issued2006en_HK
dc.identifier.citationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 59-63en_HK
dc.identifier.issn1013-9923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80126-
dc.description.abstractThe coexistence of juvenile pernicious anaemia, vitiligo and selective IgA deficiency in a Southern Chinese boy stimulated a comprehensive work-up of his immune functions. He was found to have an imbalance of T-helper cell (CD4+) and T-suppressor cell (CD8+) activity, leading to low B cell response in vitro to pokeweed-mitogen in production of IgA. Interleukin 12 production in response to various mitogens was also deficient. These abnormalities persisted despite effective vitamin B12 treatment. We speculate that the defective immunoregulatory environment is an intrinsic defect rather than an acquired phenomenon due to vitamin B12 deficiency, which may play an important role in the pathogenesis of juvenile pernicious anaemia.en_HK
dc.languageengen_HK
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.aspen_HK
dc.relation.ispartofHong Kong Journal of Paediatricsen_HK
dc.subjectInterleukin 12en_HK
dc.subjectJuvenile pernicious anaemiaen_HK
dc.subjectSelective IgA deficiencyen_HK
dc.subjectT cell dysfunctionen_HK
dc.subjectVitiligoen_HK
dc.titleJuvenile pernicious anaemia in association with vitiligo, selective IgA deficiency, defective interleukin 12 production and T cell dysfunctionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9923&volume=11&spage=59&epage=63&date=2006&atitle=Juvenile+Pernicious+Anaemia+in+Association+with+Vitiligo,+Selective+IgA+Deficiency,+Defective+Interleukin+12+Production+and+T+Cell+Dysfunctionen_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailChiang, AKS:chiangak@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityChiang, AKS=rp00403en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-31344470365en_HK
dc.identifier.hkuros114552en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-31344470365&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue1en_HK
dc.identifier.spage59en_HK
dc.identifier.epage63en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridHo, MHK=36554116300en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridJones, BM=7404958958en_HK
dc.identifier.scopusauthoridLee, TL=24483772800en_HK
dc.identifier.scopusauthoridChiang, AKS=7101623534en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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