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Article: Juvenile pernicious anaemia in association with vitiligo, selective IgA deficiency, defective interleukin 12 production and T cell dysfunction
Title | Juvenile pernicious anaemia in association with vitiligo, selective IgA deficiency, defective interleukin 12 production and T cell dysfunction |
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Authors | |
Keywords | Interleukin 12 Juvenile pernicious anaemia Selective IgA deficiency T cell dysfunction Vitiligo |
Issue Date | 2006 |
Publisher | Medcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp |
Citation | Hong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 59-63 How to Cite? |
Abstract | The coexistence of juvenile pernicious anaemia, vitiligo and selective IgA deficiency in a Southern Chinese boy stimulated a comprehensive work-up of his immune functions. He was found to have an imbalance of T-helper cell (CD4+) and T-suppressor cell (CD8+) activity, leading to low B cell response in vitro to pokeweed-mitogen in production of IgA. Interleukin 12 production in response to various mitogens was also deficient. These abnormalities persisted despite effective vitamin B12 treatment. We speculate that the defective immunoregulatory environment is an intrinsic defect rather than an acquired phenomenon due to vitamin B12 deficiency, which may play an important role in the pathogenesis of juvenile pernicious anaemia. |
Persistent Identifier | http://hdl.handle.net/10722/80126 |
ISSN | 2023 Impact Factor: 0.1 2023 SCImago Journal Rankings: 0.117 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ho, MHK | en_HK |
dc.contributor.author | Chan, GCF | en_HK |
dc.contributor.author | Jones, BM | en_HK |
dc.contributor.author | Lee, TL | en_HK |
dc.contributor.author | Chiang, AKS | en_HK |
dc.contributor.author | Ha, SY | en_HK |
dc.contributor.author | Lau, YL | en_HK |
dc.date.accessioned | 2010-09-06T08:02:42Z | - |
dc.date.available | 2010-09-06T08:02:42Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | Hong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 59-63 | en_HK |
dc.identifier.issn | 1013-9923 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/80126 | - |
dc.description.abstract | The coexistence of juvenile pernicious anaemia, vitiligo and selective IgA deficiency in a Southern Chinese boy stimulated a comprehensive work-up of his immune functions. He was found to have an imbalance of T-helper cell (CD4+) and T-suppressor cell (CD8+) activity, leading to low B cell response in vitro to pokeweed-mitogen in production of IgA. Interleukin 12 production in response to various mitogens was also deficient. These abnormalities persisted despite effective vitamin B12 treatment. We speculate that the defective immunoregulatory environment is an intrinsic defect rather than an acquired phenomenon due to vitamin B12 deficiency, which may play an important role in the pathogenesis of juvenile pernicious anaemia. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Medcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp | en_HK |
dc.relation.ispartof | Hong Kong Journal of Paediatrics | en_HK |
dc.subject | Interleukin 12 | en_HK |
dc.subject | Juvenile pernicious anaemia | en_HK |
dc.subject | Selective IgA deficiency | en_HK |
dc.subject | T cell dysfunction | en_HK |
dc.subject | Vitiligo | en_HK |
dc.title | Juvenile pernicious anaemia in association with vitiligo, selective IgA deficiency, defective interleukin 12 production and T cell dysfunction | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9923&volume=11&spage=59&epage=63&date=2006&atitle=Juvenile+Pernicious+Anaemia+in+Association+with+Vitiligo,+Selective+IgA+Deficiency,+Defective+Interleukin+12+Production+and+T+Cell+Dysfunction | en_HK |
dc.identifier.email | Chan, GCF:gcfchan@hkucc.hku.hk | en_HK |
dc.identifier.email | Chiang, AKS:chiangak@hkucc.hku.hk | en_HK |
dc.identifier.email | Lau, YL:lauylung@hkucc.hku.hk | en_HK |
dc.identifier.authority | Chan, GCF=rp00431 | en_HK |
dc.identifier.authority | Chiang, AKS=rp00403 | en_HK |
dc.identifier.authority | Lau, YL=rp00361 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.scopus | eid_2-s2.0-31344470365 | en_HK |
dc.identifier.hkuros | 114552 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-31344470365&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 11 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 59 | en_HK |
dc.identifier.epage | 63 | en_HK |
dc.publisher.place | Hong Kong | en_HK |
dc.identifier.scopusauthorid | Ho, MHK=36554116300 | en_HK |
dc.identifier.scopusauthorid | Chan, GCF=16160154400 | en_HK |
dc.identifier.scopusauthorid | Jones, BM=7404958958 | en_HK |
dc.identifier.scopusauthorid | Lee, TL=24483772800 | en_HK |
dc.identifier.scopusauthorid | Chiang, AKS=7101623534 | en_HK |
dc.identifier.scopusauthorid | Ha, SY=7202501115 | en_HK |
dc.identifier.scopusauthorid | Lau, YL=7201403380 | en_HK |
dc.identifier.issnl | 1013-9923 | - |