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Article: Near-haploid common acute lymphoblastic leukaemia of childhood with a second hyperdiploid line: A DNA ploidy and fluorescence in-situ hybridization study

TitleNear-haploid common acute lymphoblastic leukaemia of childhood with a second hyperdiploid line: A DNA ploidy and fluorescence in-situ hybridization study
Authors
KeywordsALL
FISH
Hyperdiploid
Near-haploid
T(9
12) (q11
q13)
Issue Date1998
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 1998, v. 103 n. 3, p. 750-755 How to Cite?
AbstractNear-haploidy is a rare cytogenetic finding in childhood acute lymphoblastic leukaemia (ALL) and is associated with a poor prognosis. A second hyperdiploid line, occurring presumably by endoreduplication of the near-haploid stemline, is often observed. We present a case of common ALL in relapse characterized morphologically by a dual population of small and large lymphoblasts. Cytogenetic analysis supplemented with fluorescence in-situ hybridization (FISH) studies localized near-haploidy and hyperdiploidy to the small and large blast population respectively. DNA ploidy determination confirmed two abnormal clones with near-haploidy as the predominant one. A novel t(9;12)(q11;q13) was present in the near-haploid clone and was duplicated in the hyperdiploid clone. This finding identified cells bearing near-haploidy to be the clonogenic population following malignant transformation and confirmed endoreduplication as the mechanism for the presence of associated hyperdiploidy.
Persistent Identifierhttp://hdl.handle.net/10722/80119
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMa, SKen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorWan, TSKen_HK
dc.contributor.authorLam, CKen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorChan, LCen_HK
dc.date.accessioned2010-09-06T08:02:37Z-
dc.date.available2010-09-06T08:02:37Z-
dc.date.issued1998en_HK
dc.identifier.citationBritish Journal Of Haematology, 1998, v. 103 n. 3, p. 750-755en_HK
dc.identifier.issn0007-1048en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80119-
dc.description.abstractNear-haploidy is a rare cytogenetic finding in childhood acute lymphoblastic leukaemia (ALL) and is associated with a poor prognosis. A second hyperdiploid line, occurring presumably by endoreduplication of the near-haploid stemline, is often observed. We present a case of common ALL in relapse characterized morphologically by a dual population of small and large lymphoblasts. Cytogenetic analysis supplemented with fluorescence in-situ hybridization (FISH) studies localized near-haploidy and hyperdiploidy to the small and large blast population respectively. DNA ploidy determination confirmed two abnormal clones with near-haploidy as the predominant one. A novel t(9;12)(q11;q13) was present in the near-haploid clone and was duplicated in the hyperdiploid clone. This finding identified cells bearing near-haploidy to be the clonogenic population following malignant transformation and confirmed endoreduplication as the mechanism for the presence of associated hyperdiploidy.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_HK
dc.relation.ispartofBritish Journal of Haematologyen_HK
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectALLen_HK
dc.subjectFISHen_HK
dc.subjectHyperdiploiden_HK
dc.subjectNear-haploiden_HK
dc.subjectT(9en_HK
dc.subject12) (q11en_HK
dc.subjectq13)en_HK
dc.subject.meshChilden_HK
dc.subject.meshChromosomes, Human, Pair 12 - geneticsen_HK
dc.subject.meshChromosomes, Human, Pair 9 - geneticsen_HK
dc.subject.meshClone Cellsen_HK
dc.subject.meshDNA, Neoplasm - geneticsen_HK
dc.subject.meshDiploidyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHaploidyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Hybridization, Fluorescenceen_HK
dc.subject.meshKaryotypingen_HK
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma - geneticsen_HK
dc.subject.meshTranslocation, Geneticen_HK
dc.titleNear-haploid common acute lymphoblastic leukaemia of childhood with a second hyperdiploid line: A DNA ploidy and fluorescence in-situ hybridization studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1048&volume=103&spage=750&epage=755&date=1998&atitle=Near-haploid+common+acute+lymphoblastic+leukaemia+of+childhood+with+a+second+hyperdiploid+line:+a+DNA+ploidy+and+fluorescence+in-situ+hybridization+studyen_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1365-2141.1998.01044.xen_HK
dc.identifier.pmid9858226en_HK
dc.identifier.scopuseid_2-s2.0-0031729221en_HK
dc.identifier.hkuros39134en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031729221&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume103en_HK
dc.identifier.issue3en_HK
dc.identifier.spage750en_HK
dc.identifier.epage755en_HK
dc.identifier.isiWOS:000077457400022-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMa, SK=9042504200en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridWan, TSK=25623981600en_HK
dc.identifier.scopusauthoridLam, CK=7402990801en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK

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