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Article: Cytotoxic chemotherapy has minimal direct effect on gastric myoelectric activity in children with 5HT3 antagonist prophylaxis

TitleCytotoxic chemotherapy has minimal direct effect on gastric myoelectric activity in children with 5HT3 antagonist prophylaxis
Authors
KeywordsCancer
Chemotherapy
Childhood cancer
Electrogastrography
Vomiting
Issue Date2000
PublisherJohn Wiley & Sons, Inc.
Citation
Medical And Pediatric Oncology, 2000, v. 34 n. 6, p. 421-423 How to Cite?
AbstractBackground. Cancer patients receiving cytotoxic chemotherapy frequently develop nausea and vomiting. The direct effect of chemotherapy on gastric pacemaker is not clear. The objective of this study was to assess the direct interference of gastric electrical activity by chemotherapeutic agents as a possible cause of vomiting using electrogastrography (EGG). Procedure. Fasting surface EGGs were recorded in 24 children with malignancy and 24 age- matched controls. All oncology patients received the intravenous prophylactic ondansetron. According to the known emetic potential of the medications they received, the children were divided into mild, moderate, and severe groups. The EGG recordings of oncology patients were segmented into prechemotherapy period, chemotherapy period, and emetic period. The EGG data from each period were collected and analyzed (paired t-test and Mann-Whitney U test). Results. There were 24 children (M:F ratio: 14:10), with a mean age of 9.6 years. Eight children vomited during the course of recording (0/3 from the mild group, 2/6 from the moderate group, and 6/15 from the severe group). The average duration of intravenous medication infusion was 7.8 hr (range 2 min to 24 hr). There was no difference between the EGG of normal control and the prechemotherapy EGG of the oncology patients. No difference was detected between the EGG data from the prechemotherapy period and the chemotherapy period. A statistically significant increase in tachygastria was detected in emetic periods (28 episodes, mean duration 5 min; P= 0.01). Conclusions. Insignificant EGG changes during chemotherapy suggest that chemotherapy has a minimal direct effect on gastric pacemaker. Tachygastria seemed to be a secondary effect of vomiting rather than the cause of it. These preliminary findings suggest that efforts to modify gastric electrical rhythm as a means of management of chemotherapy-induced vomiting may be futile. Further studies to identify factors responsible for vomiting are warranted. (C) 2000 Wiley- Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/80114
ISSN
2005 Impact Factor: 1.649
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, Wen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2010-09-06T08:02:34Z-
dc.date.available2010-09-06T08:02:34Z-
dc.date.issued2000en_HK
dc.identifier.citationMedical And Pediatric Oncology, 2000, v. 34 n. 6, p. 421-423en_HK
dc.identifier.issn0098-1532en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80114-
dc.description.abstractBackground. Cancer patients receiving cytotoxic chemotherapy frequently develop nausea and vomiting. The direct effect of chemotherapy on gastric pacemaker is not clear. The objective of this study was to assess the direct interference of gastric electrical activity by chemotherapeutic agents as a possible cause of vomiting using electrogastrography (EGG). Procedure. Fasting surface EGGs were recorded in 24 children with malignancy and 24 age- matched controls. All oncology patients received the intravenous prophylactic ondansetron. According to the known emetic potential of the medications they received, the children were divided into mild, moderate, and severe groups. The EGG recordings of oncology patients were segmented into prechemotherapy period, chemotherapy period, and emetic period. The EGG data from each period were collected and analyzed (paired t-test and Mann-Whitney U test). Results. There were 24 children (M:F ratio: 14:10), with a mean age of 9.6 years. Eight children vomited during the course of recording (0/3 from the mild group, 2/6 from the moderate group, and 6/15 from the severe group). The average duration of intravenous medication infusion was 7.8 hr (range 2 min to 24 hr). There was no difference between the EGG of normal control and the prechemotherapy EGG of the oncology patients. No difference was detected between the EGG data from the prechemotherapy period and the chemotherapy period. A statistically significant increase in tachygastria was detected in emetic periods (28 episodes, mean duration 5 min; P= 0.01). Conclusions. Insignificant EGG changes during chemotherapy suggest that chemotherapy has a minimal direct effect on gastric pacemaker. Tachygastria seemed to be a secondary effect of vomiting rather than the cause of it. These preliminary findings suggest that efforts to modify gastric electrical rhythm as a means of management of chemotherapy-induced vomiting may be futile. Further studies to identify factors responsible for vomiting are warranted. (C) 2000 Wiley- Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc.en_HK
dc.relation.ispartofMedical and Pediatric Oncologyen_HK
dc.rightsMedical and Pediatric Oncology. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectCanceren_HK
dc.subjectChemotherapyen_HK
dc.subjectChildhood canceren_HK
dc.subjectElectrogastrographyen_HK
dc.subjectVomitingen_HK
dc.titleCytotoxic chemotherapy has minimal direct effect on gastric myoelectric activity in children with 5HT3 antagonist prophylaxisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0098-1532&volume=34&spage=421&epage=423&date=2000&atitle=Cytotoxic+chemotherapy+has+minimal+direct+effect+on+gastric+myoelectric+activity+in+children+with+5+HT3+antagonist+prophylaxisen_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailTam, PKH:paultam@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1096-911X(200006)34:6<421::AID-MPO7>3.0.CO;2-6en_HK
dc.identifier.pmid10842249-
dc.identifier.scopuseid_2-s2.0-0034119441en_HK
dc.identifier.hkuros48687en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034119441&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue6en_HK
dc.identifier.spage421en_HK
dc.identifier.epage423en_HK
dc.identifier.isiWOS:000087286500007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheng, W=7402169228en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK

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