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Article: Prediction of the growth response of short prepubertal children treated with growth hormone

TitlePrediction of the growth response of short prepubertal children treated with growth hormone
Authors
KeywordsGH status
GH treatment
Growth prediction
Growth response
Prepubertal children
Issue Date1995
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1328-8067&site=1
Citation
Acta Paediatrica, International Journal Of Paediatrics, 1995, v. 84 n. 1, p. 51-57 How to Cite?
AbstractThe aim of this study was to identify predictors of the growth response to growth hormone (GH) during the first 2 years of GH treatment, using auxological data and the maximum GH response (GH(max)) to provocation tests. The patients were 169 prepubertal short children (27F, 142M), with G(max) values ranging from 0 to 65 mU/l. Their mean age (± SD) was 8.3 ± 2.4 years (range 3-13 years), mean height SDS -3.0 ± 0.7 (range -1.5 to -6.0 SDS) and mean pretreatment height velocity was normal (± 0.0 SDS) (range 1.6 to ± 0.9 SDS). The increase in height SDS during the first 2 years of GH treatment (0.1 U/kg/day) varied from 0.10 to 3.75 SDS, with younger children having a better growth response. Individual growth responses correlated (p < 0.001) with GH(max) (r =- 0.37), age (r = -0.35), 1-year pretreatment delta SDS (r = -0.25), mid-parental height SDS (r = 0.34), height SDS at start of treatment (r = -0.22) and difference between height SDS of an individual child at the onset of GH treatment and mid-parental height expressed in SDS (diff SDS) (r = -0.43). In a multiple stepwise linear regression model, diff SDS and log GH(max) were found to be the strongest predictors of the magnitude of the growth response. In the short children in this study who exhibited a broad range of GH(max) values, 33% of the growth response during the first 2 years of treatment could be predicted.
Persistent Identifierhttp://hdl.handle.net/10722/80092
ISSN
2015 Impact Factor: 1.647
2015 SCImago Journal Rankings: 0.794
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKristrom, Ben_HK
dc.contributor.authorKarlberg, Jen_HK
dc.contributor.authorAlbertssonWikland, Ken_HK
dc.date.accessioned2010-09-06T08:02:18Z-
dc.date.available2010-09-06T08:02:18Z-
dc.date.issued1995en_HK
dc.identifier.citationActa Paediatrica, International Journal Of Paediatrics, 1995, v. 84 n. 1, p. 51-57en_HK
dc.identifier.issn0803-5253en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80092-
dc.description.abstractThe aim of this study was to identify predictors of the growth response to growth hormone (GH) during the first 2 years of GH treatment, using auxological data and the maximum GH response (GH(max)) to provocation tests. The patients were 169 prepubertal short children (27F, 142M), with G(max) values ranging from 0 to 65 mU/l. Their mean age (± SD) was 8.3 ± 2.4 years (range 3-13 years), mean height SDS -3.0 ± 0.7 (range -1.5 to -6.0 SDS) and mean pretreatment height velocity was normal (± 0.0 SDS) (range 1.6 to ± 0.9 SDS). The increase in height SDS during the first 2 years of GH treatment (0.1 U/kg/day) varied from 0.10 to 3.75 SDS, with younger children having a better growth response. Individual growth responses correlated (p < 0.001) with GH(max) (r =- 0.37), age (r = -0.35), 1-year pretreatment delta SDS (r = -0.25), mid-parental height SDS (r = 0.34), height SDS at start of treatment (r = -0.22) and difference between height SDS of an individual child at the onset of GH treatment and mid-parental height expressed in SDS (diff SDS) (r = -0.43). In a multiple stepwise linear regression model, diff SDS and log GH(max) were found to be the strongest predictors of the magnitude of the growth response. In the short children in this study who exhibited a broad range of GH(max) values, 33% of the growth response during the first 2 years of treatment could be predicted.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1328-8067&site=1en_HK
dc.relation.ispartofActa Paediatrica, International Journal of Paediatricsen_HK
dc.rightsActa Paediatrica. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectGH statusen_HK
dc.subjectGH treatmenten_HK
dc.subjectGrowth predictionen_HK
dc.subjectGrowth responseen_HK
dc.subjectPrepubertal childrenen_HK
dc.titlePrediction of the growth response of short prepubertal children treated with growth hormoneen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0803-5253&volume=84&spage=51&epage=57&date=1995&atitle=Prediction+of+the+growth+response+of+short+prepubertal+children+treated+with+growth+hormoneen_HK
dc.identifier.emailKarlberg, J: jpekarl@hkucc.hku.hken_HK
dc.identifier.authorityKarlberg, J=rp00400en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid7734899-
dc.identifier.scopuseid_2-s2.0-0028894181en_HK
dc.identifier.hkuros2901en_HK
dc.identifier.volume84en_HK
dc.identifier.issue1en_HK
dc.identifier.spage51en_HK
dc.identifier.epage57en_HK
dc.identifier.isiWOS:A1995QF43200012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKristrom, B=6603784721en_HK
dc.identifier.scopusauthoridKarlberg, J=7005218406en_HK
dc.identifier.scopusauthoridAlbertssonWikland, K=19639814800en_HK

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