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Article: Overnight urinary growth hormone in normally growing prepubertal children: Effect of urine volume

TitleOvernight urinary growth hormone in normally growing prepubertal children: Effect of urine volume
Authors
KeywordsChildhood
Growth
Growth hormone
Urine
Issue Date1998
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/HRE
Citation
Hormone Research, 1998, v. 49 n. 1, p. 8-16 How to Cite?
AbstractGrowth hormone excretion can easily be measured in the urine using ultrasensitive methods. The large day-to-day variation has, however, restricted its diagnostic usefulness. The present study aimed to evaluate the individual variation of GH in the urine (uGH) during normal prepubertal growth. Eighty-four prepubertal normally growing children were followed monthly for 13 months. During this period, 3207 overnight urine samples were collected. The urine collection time was unrelated to the uGH concentration (p > 0.05), while there was a significant negative correlation between the uGH concentration and urine volume (the Spearman correlation coefficient of -0.33, p < 0.0001), while the calculated excretion of GH in the urine showed a positive correlation with the urine volume (r = 0.35; p < 0.0001). A reference chart, based on SD scores, was developed in order to avoid this volume dependency and to optimally normalize the skewed distribution of the uGH concentrations. The use of this model reduced the individual day-to-day variation of uGH from a coefficient of variation of 43 to 21%. Differences in mean cross-sectional urinary GH concentration was found between different months exceeding the expected methodological variation. This variation showed no seasonal pattern. Only 0.2% of triplicate values (three consecutive overnight uGH values) were all below -2 SD scores and 0.1% were above +2 SD scores. The mean uGH SD score for the boys was 0.01 (SD = 0.98), which was similar to that for the girls (-0.04; SD = 1.06). We found that uGH excretion can be estimated in a more robust way, using a SD score based reference chart that handles both the positive correlation between urinary GH and urine volume and the skewed distribution of urinary GH. This model reduced the day-to-day variability of uGH by half. Overestimation of GH in large urine volumes may be due to increased gradient between GH in urine and serum following increased urine volumes.
Persistent Identifierhttp://hdl.handle.net/10722/80091
ISSN
2011 Impact Factor: 2.48
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGelander, Len_HK
dc.contributor.authorKarlberg, JPEen_HK
dc.contributor.authorLarsson, LAen_HK
dc.contributor.authorRosberg, Sen_HK
dc.contributor.authorAlbertssonWikland, Ken_HK
dc.date.accessioned2010-09-06T08:02:18Z-
dc.date.available2010-09-06T08:02:18Z-
dc.date.issued1998en_HK
dc.identifier.citationHormone Research, 1998, v. 49 n. 1, p. 8-16en_HK
dc.identifier.issn0301-0163en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80091-
dc.description.abstractGrowth hormone excretion can easily be measured in the urine using ultrasensitive methods. The large day-to-day variation has, however, restricted its diagnostic usefulness. The present study aimed to evaluate the individual variation of GH in the urine (uGH) during normal prepubertal growth. Eighty-four prepubertal normally growing children were followed monthly for 13 months. During this period, 3207 overnight urine samples were collected. The urine collection time was unrelated to the uGH concentration (p > 0.05), while there was a significant negative correlation between the uGH concentration and urine volume (the Spearman correlation coefficient of -0.33, p < 0.0001), while the calculated excretion of GH in the urine showed a positive correlation with the urine volume (r = 0.35; p < 0.0001). A reference chart, based on SD scores, was developed in order to avoid this volume dependency and to optimally normalize the skewed distribution of the uGH concentrations. The use of this model reduced the individual day-to-day variation of uGH from a coefficient of variation of 43 to 21%. Differences in mean cross-sectional urinary GH concentration was found between different months exceeding the expected methodological variation. This variation showed no seasonal pattern. Only 0.2% of triplicate values (three consecutive overnight uGH values) were all below -2 SD scores and 0.1% were above +2 SD scores. The mean uGH SD score for the boys was 0.01 (SD = 0.98), which was similar to that for the girls (-0.04; SD = 1.06). We found that uGH excretion can be estimated in a more robust way, using a SD score based reference chart that handles both the positive correlation between urinary GH and urine volume and the skewed distribution of urinary GH. This model reduced the day-to-day variability of uGH by half. Overestimation of GH in large urine volumes may be due to increased gradient between GH in urine and serum following increased urine volumes.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/HREen_HK
dc.relation.ispartofHormone Researchen_HK
dc.rightsHormone Research. Copyright © S Karger AG.en_HK
dc.subjectChildhooden_HK
dc.subjectGrowthen_HK
dc.subjectGrowth hormoneen_HK
dc.subjectUrineen_HK
dc.titleOvernight urinary growth hormone in normally growing prepubertal children: Effect of urine volumeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0301-0163&volume=49&spage=8&epage=16&date=1998&atitle=Overnight+urinary+growth+hormone+in+normally+growing+prepubertal+children:+effect+of+urine+volumeen_HK
dc.identifier.emailKarlberg, JPE: jpekarl@hkucc.hku.hken_HK
dc.identifier.authorityKarlberg, JPE=rp00400en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000023119en_HK
dc.identifier.pmid9438779-
dc.identifier.scopuseid_2-s2.0-0031974834en_HK
dc.identifier.hkuros29612en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031974834&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue1en_HK
dc.identifier.spage8en_HK
dc.identifier.epage16en_HK
dc.identifier.isiWOS:000071315000002-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridGelander, L=6602383676en_HK
dc.identifier.scopusauthoridKarlberg, JPE=7005218406en_HK
dc.identifier.scopusauthoridLarsson, LA=7402201043en_HK
dc.identifier.scopusauthoridRosberg, S=7003930898en_HK
dc.identifier.scopusauthoridAlbertssonWikland, K=19639814800en_HK

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