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Article: B-cell and T-regulatory cell dysfunction in six Chinese children with hypogammaglobulinaemia

TitleB-cell and T-regulatory cell dysfunction in six Chinese children with hypogammaglobulinaemia
Authors
KeywordsB-lymphocytes
Hypogammaglobulinaemia
Plaque-forming cells
T-helper cells
T-suppressor cells
Issue Date1993
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00431/index.htm
Citation
European Journal Of Pediatrics, 1993, v. 152 n. 5, p. 409-413 How to Cite?
AbstractWe report six Chinese boys with hypogammaglobulinaemia. All but one had very low or undetectable circulating B-lymphocytes, two had reversed CD4/CD8 ratios (in one of whom this later became normal), one had reduced lymphocyte proliferative responses to concanavalin A and pokeweed mitogen and three had deficient responses to OKT3. Generation of antibody-secreting cells in response to pokeweed mitogen was markedly defective in all patients. Co-cultures of purified lymphocyte subsets from the patients with those of normal donors revealed that in addition to B-cell deficiency seen in all patients, two had T-helper cell deficiency and two had T-suppressor cell hyperactivity. One of the latter patients was treated with cimetidine in an attempt to ablate histamine type 2 receptor-bearing suppressor cells: the absolute number of such cells was temporarily reduced but there was no concurrent correction of the functional hyperactivity. These studies point to the variable nature of T-regulatory cell deficiencies in hypogammaglobulinaemia.
Persistent Identifierhttp://hdl.handle.net/10722/80090
ISSN
2015 Impact Factor: 1.791
2015 SCImago Journal Rankings: 0.772
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJones, BMen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorWong, KLen_HK
dc.date.accessioned2010-09-06T08:02:17Z-
dc.date.available2010-09-06T08:02:17Z-
dc.date.issued1993en_HK
dc.identifier.citationEuropean Journal Of Pediatrics, 1993, v. 152 n. 5, p. 409-413en_HK
dc.identifier.issn0340-6199en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80090-
dc.description.abstractWe report six Chinese boys with hypogammaglobulinaemia. All but one had very low or undetectable circulating B-lymphocytes, two had reversed CD4/CD8 ratios (in one of whom this later became normal), one had reduced lymphocyte proliferative responses to concanavalin A and pokeweed mitogen and three had deficient responses to OKT3. Generation of antibody-secreting cells in response to pokeweed mitogen was markedly defective in all patients. Co-cultures of purified lymphocyte subsets from the patients with those of normal donors revealed that in addition to B-cell deficiency seen in all patients, two had T-helper cell deficiency and two had T-suppressor cell hyperactivity. One of the latter patients was treated with cimetidine in an attempt to ablate histamine type 2 receptor-bearing suppressor cells: the absolute number of such cells was temporarily reduced but there was no concurrent correction of the functional hyperactivity. These studies point to the variable nature of T-regulatory cell deficiencies in hypogammaglobulinaemia.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00431/index.htmen_HK
dc.relation.ispartofEuropean Journal of Pediatricsen_HK
dc.subjectB-lymphocytesen_HK
dc.subjectHypogammaglobulinaemiaen_HK
dc.subjectPlaque-forming cellsen_HK
dc.subjectT-helper cellsen_HK
dc.subjectT-suppressor cellsen_HK
dc.titleB-cell and T-regulatory cell dysfunction in six Chinese children with hypogammaglobulinaemiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0340-6199&volume=152&spage=409&epage=413&date=1993&atitle=B-cell+and+T-regulatory+cell+dysfunction+in+six+Chinese+children+with+hypogammaglobulinaemiaen_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8319707-
dc.identifier.scopuseid_2-s2.0-0027264931en_HK
dc.identifier.hkuros30220en_HK
dc.identifier.volume152en_HK
dc.identifier.issue5en_HK
dc.identifier.spage409en_HK
dc.identifier.epage413en_HK
dc.identifier.isiWOS:A1993LA20000010-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridJones, BM=7404958958en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridWong, KL=37096566800en_HK

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