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Article: Prognostic factors in children requiring admission to an intensive care unit after hematopoietic stem cell transplant

TitlePrognostic factors in children requiring admission to an intensive care unit after hematopoietic stem cell transplant
Authors
KeywordsHematopoietic stem cell transplant
Intensive care
Pediatric
Prognosis
Scoring system
Issue Date2004
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/3182
Citation
Hematological Oncology, 2004, v. 22 n. 1, p. 1-9 How to Cite?
AbstractThe objectives of this study are to identify prognostic factors of survival to discharge in pediatric hematopoietic stem cell transplant (HSCT) recipients requiring intensive care unit (ICU) admission, and to determine the utility of the Oncological Pediatric Risk of Mortality (O-PRISM) in predicting death of these patients. A retrospective cohort of 125 pediatric HSCT recipients from October 1992 to September 2002 was analysed to evaluate risk factors of mortality in those admitted to ICU after HSCT. Nineteen patients (median age 7.8 years, 14 boys) required 24 ICU admissions post-HSCT. The most frequent underlying diseases were acute myeloid leukemia (n = 5). The survival rate on discharge from ICU was 54%. In univariate analysis, risk factors of mortality included earlier requirement of ICU admission post-HSCT (median 34 versus 166 days, p = 0.002), a longer delay before ICU admission (median 12 versus 5 h, p = 0.02), lack of neutrophil (p = 0.011) or platelet engraftment (p = 0.008), macroscopic hemorrhage (p < 0.001), tachypnoea (p = 0.033), hypoxemia (p = 0.031), renal impairment (p = 0.011), coagulopathy (p = 0.012), mechanical ventilation (p < 0.001), and an increasing number of organ failures (p = 0.003). Macroscopic hemorrhage and mechanical ventilation remained significant in multivariate analysis. Both PRISM and O-PRISM scores were significant composite prognosticators. It was concluded that mortality of post-HSCT children requiring ICU admission is high, especially in those with poor prognosticators. Copyright © 2004 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/80068
ISSN
2015 Impact Factor: 3.494
2015 SCImago Journal Rankings: 0.767
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheuk, DKLen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorLee, SLen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorTsoi, NSen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-06T08:02:00Z-
dc.date.available2010-09-06T08:02:00Z-
dc.date.issued2004en_HK
dc.identifier.citationHematological Oncology, 2004, v. 22 n. 1, p. 1-9en_HK
dc.identifier.issn0278-0232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80068-
dc.description.abstractThe objectives of this study are to identify prognostic factors of survival to discharge in pediatric hematopoietic stem cell transplant (HSCT) recipients requiring intensive care unit (ICU) admission, and to determine the utility of the Oncological Pediatric Risk of Mortality (O-PRISM) in predicting death of these patients. A retrospective cohort of 125 pediatric HSCT recipients from October 1992 to September 2002 was analysed to evaluate risk factors of mortality in those admitted to ICU after HSCT. Nineteen patients (median age 7.8 years, 14 boys) required 24 ICU admissions post-HSCT. The most frequent underlying diseases were acute myeloid leukemia (n = 5). The survival rate on discharge from ICU was 54%. In univariate analysis, risk factors of mortality included earlier requirement of ICU admission post-HSCT (median 34 versus 166 days, p = 0.002), a longer delay before ICU admission (median 12 versus 5 h, p = 0.02), lack of neutrophil (p = 0.011) or platelet engraftment (p = 0.008), macroscopic hemorrhage (p < 0.001), tachypnoea (p = 0.033), hypoxemia (p = 0.031), renal impairment (p = 0.011), coagulopathy (p = 0.012), mechanical ventilation (p < 0.001), and an increasing number of organ failures (p = 0.003). Macroscopic hemorrhage and mechanical ventilation remained significant in multivariate analysis. Both PRISM and O-PRISM scores were significant composite prognosticators. It was concluded that mortality of post-HSCT children requiring ICU admission is high, especially in those with poor prognosticators. Copyright © 2004 John Wiley & Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/3182en_HK
dc.relation.ispartofHematological Oncologyen_HK
dc.rightsHematological Oncology. Copyright © John Wiley & Sons Ltd.en_HK
dc.subjectHematopoietic stem cell transplanten_HK
dc.subjectIntensive careen_HK
dc.subjectPediatricen_HK
dc.subjectPrognosisen_HK
dc.subjectScoring systemen_HK
dc.titlePrognostic factors in children requiring admission to an intensive care unit after hematopoietic stem cell transplanten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0278-0232&volume=22&spage=1&epage=9&date=2004&atitle=Prognostic+factors+in+children+requiring+admission+to+an+intensive+care+unit+after+hematopoietic+stem+cell+transplanten_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hon.724en_HK
dc.identifier.pmid15152366-
dc.identifier.scopuseid_2-s2.0-2642560196en_HK
dc.identifier.hkuros88097en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2642560196&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue1en_HK
dc.identifier.spage1en_HK
dc.identifier.epage9en_HK
dc.identifier.isiWOS:000221733600001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheuk, DKL=8705936100en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridLee, SL=8708381600en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridTsoi, NS=6603693887en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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