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Article: Anti-cyclic citrullinated peptide: Diagnostic and prognostic values in juvenile idiopathic arthritis and rheumatoid arthritis in a Chinese population

TitleAnti-cyclic citrullinated peptide: Diagnostic and prognostic values in juvenile idiopathic arthritis and rheumatoid arthritis in a Chinese population
Authors
Issue Date2005
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03009742.asp
Citation
Scandinavian Journal Of Rheumatology, 2005, v. 34 n. 5, p. 359-366 How to Cite?
AbstractObjective: The incidence and clinical significance of anti-cyclic citrullinated peptide (CCP) antibodies in a cohort of Chinese patients with juvenile idiopathic arthritis (JIA) and adults with rheumatoid arthritis (RA) were studied. Methods: Anti-CCP antibodies were determined by enzyme-linked immunosorbent assay (ELISA) in 59 patients with JIA, 129 adult RA patients, 48 children with diseases other than JIA, 68 adult patients with rheumatic diseases other than RA, and 60 normal adults. Associations between anti-CCP antibodies and clinical and laboratory parameters were determined by Fisher's exact test. Results: Six of 59 (10.2%) patients with JIA and 71 of 129 (55%) patients with RA were positive for anti-CCP. Four of five RF-positive JIA patients and two of 54 RF-negative JIA patients were positive (p<0.001). One paediatric patient with allergy (0.9%) and two adult patients with rheumatic diseases other than RA (2.3%) were positive. All healthy controls were negative for anti-CCP. The specificity was 99.1% for JIA and 98.4% for RA. The sensitivity was 10.2% for JIA and 55% for RA. Positive predictive values were 85.7% for JIA and 97.3% for RA and negative predictive values were 66.9% for JIA and 68.5% for RA. Conclusion: The anti-CCP antibody assay is a valuable tool for the diagnosis of RA and a subset of JIA in Chinese patients. It could be a useful predictive test for joint erosion in JIA of the polyarticular RF-positive subset and may be influential in the choice of the best therapeutic strategy in patients with recent-onset arthritis. © 2005 Taylor & Francis on license from Scandinavian Rheumatology Research Foundation.
Persistent Identifierhttp://hdl.handle.net/10722/80052
ISSN
2015 Impact Factor: 2.307
2015 SCImago Journal Rankings: 1.125
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwok, JSYen_HK
dc.contributor.authorHui, KHen_HK
dc.contributor.authorLee, TLen_HK
dc.contributor.authorWong, Wen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorWong, RWSen_HK
dc.contributor.authorKim, DLen_HK
dc.contributor.authorJones, BMen_HK
dc.date.accessioned2010-09-06T08:01:49Z-
dc.date.available2010-09-06T08:01:49Z-
dc.date.issued2005en_HK
dc.identifier.citationScandinavian Journal Of Rheumatology, 2005, v. 34 n. 5, p. 359-366en_HK
dc.identifier.issn0300-9742en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80052-
dc.description.abstractObjective: The incidence and clinical significance of anti-cyclic citrullinated peptide (CCP) antibodies in a cohort of Chinese patients with juvenile idiopathic arthritis (JIA) and adults with rheumatoid arthritis (RA) were studied. Methods: Anti-CCP antibodies were determined by enzyme-linked immunosorbent assay (ELISA) in 59 patients with JIA, 129 adult RA patients, 48 children with diseases other than JIA, 68 adult patients with rheumatic diseases other than RA, and 60 normal adults. Associations between anti-CCP antibodies and clinical and laboratory parameters were determined by Fisher's exact test. Results: Six of 59 (10.2%) patients with JIA and 71 of 129 (55%) patients with RA were positive for anti-CCP. Four of five RF-positive JIA patients and two of 54 RF-negative JIA patients were positive (p<0.001). One paediatric patient with allergy (0.9%) and two adult patients with rheumatic diseases other than RA (2.3%) were positive. All healthy controls were negative for anti-CCP. The specificity was 99.1% for JIA and 98.4% for RA. The sensitivity was 10.2% for JIA and 55% for RA. Positive predictive values were 85.7% for JIA and 97.3% for RA and negative predictive values were 66.9% for JIA and 68.5% for RA. Conclusion: The anti-CCP antibody assay is a valuable tool for the diagnosis of RA and a subset of JIA in Chinese patients. It could be a useful predictive test for joint erosion in JIA of the polyarticular RF-positive subset and may be influential in the choice of the best therapeutic strategy in patients with recent-onset arthritis. © 2005 Taylor & Francis on license from Scandinavian Rheumatology Research Foundation.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03009742.aspen_HK
dc.relation.ispartofScandinavian Journal of Rheumatologyen_HK
dc.rightsScandinavian Journal of Rheumatology. Copyright © Informa Healthcare.en_HK
dc.titleAnti-cyclic citrullinated peptide: Diagnostic and prognostic values in juvenile idiopathic arthritis and rheumatoid arthritis in a Chinese populationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-9742&volume=34&issue=5&spage=359&epage=366&date=2005&atitle=Anti-cyclic+citrullinated+peptide:+diagnostic+and+prognostic+values+in+juvenile+idiopathic+arthritis+and+rheumatoid+arthritis+in+a+Chinese+populationen_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/03009740510026634en_HK
dc.identifier.pmid16234183-
dc.identifier.scopuseid_2-s2.0-27544512187en_HK
dc.identifier.hkuros114302en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-27544512187&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue5en_HK
dc.identifier.spage359en_HK
dc.identifier.epage366en_HK
dc.identifier.isiWOS:000232610200004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKwok, JSY=7006208874en_HK
dc.identifier.scopusauthoridHui, KH=8851798900en_HK
dc.identifier.scopusauthoridLee, TL=8508917400en_HK
dc.identifier.scopusauthoridWong, W=35789454600en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridWong, RWS=34875928200en_HK
dc.identifier.scopusauthoridKim, DL=8851799400en_HK
dc.identifier.scopusauthoridJones, BM=7404958958en_HK
dc.identifier.citeulike383264-

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