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Article: Early child health in Lahore, Pakistan: II. Inbreeding

TitleEarly child health in Lahore, Pakistan: II. Inbreeding
Authors
Keywordsbirth defects
inbreeding
Pakistan
urbanization
Issue Date1993
Citation
Acta Paediatrica, International Journal Of Paediatrics, Supplement, 1993, v. 82 n. 390, p. 17-26 How to Cite?
AbstractThe prevalence of consanguineous marriages was studied in 940 families belonging to four different socio-economic groups in and around Lahore, Pakistan. The births occurring in these families from September 1984 to March 1987 were also investigated for birth defects. The overall prevalence of consanguineous marriages was 46%. The first cousin marriages were most common (67%), followed by the marriages between second cousins, 19%. The prevalence of consanguineous marriages was clearly associated with the socio-economic status of the study groups; 50% of the marriages was related in the periurban slum, 49% in the village, 44% in the urban slum and 31% in the upper middle class. The birth defects were also more prevalent in the poorer areas, being highest in the periurban slum (17.7%) followed by the urban slum (15.6%) and then the village (14.8%) and lowest in the upper middle class (12.3%). Although, the frequency of both consanguinity and birth defects were related with the socio-economic levels of the study groups, there was no association between inbreeding and birth defects. Perhaps, deleterious recessive genes for birth defects have been 'bred out', because of continuous inbreeding over generations in this population. There was a significant predilection of major birth defects in boys without clear sex linkage. The conclusion is that the rate of consanguineous marriages was high, especially in the poorer areas, but the relationship between consanguineous marriages and birth defects was little or none. However, other child health indicators may be affected by consanguineous marriages.
Persistent Identifierhttp://hdl.handle.net/10722/80047
ISSN
2014 SCImago Journal Rankings: 0.123
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYaqoob, Men_HK
dc.contributor.authorGustavson, KHen_HK
dc.contributor.authorJalil, Fen_HK
dc.contributor.authorKarlberg, Jen_HK
dc.contributor.authorIselius, Len_HK
dc.date.accessioned2010-09-06T08:01:45Z-
dc.date.available2010-09-06T08:01:45Z-
dc.date.issued1993en_HK
dc.identifier.citationActa Paediatrica, International Journal Of Paediatrics, Supplement, 1993, v. 82 n. 390, p. 17-26en_HK
dc.identifier.issn0803-5326en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80047-
dc.description.abstractThe prevalence of consanguineous marriages was studied in 940 families belonging to four different socio-economic groups in and around Lahore, Pakistan. The births occurring in these families from September 1984 to March 1987 were also investigated for birth defects. The overall prevalence of consanguineous marriages was 46%. The first cousin marriages were most common (67%), followed by the marriages between second cousins, 19%. The prevalence of consanguineous marriages was clearly associated with the socio-economic status of the study groups; 50% of the marriages was related in the periurban slum, 49% in the village, 44% in the urban slum and 31% in the upper middle class. The birth defects were also more prevalent in the poorer areas, being highest in the periurban slum (17.7%) followed by the urban slum (15.6%) and then the village (14.8%) and lowest in the upper middle class (12.3%). Although, the frequency of both consanguinity and birth defects were related with the socio-economic levels of the study groups, there was no association between inbreeding and birth defects. Perhaps, deleterious recessive genes for birth defects have been 'bred out', because of continuous inbreeding over generations in this population. There was a significant predilection of major birth defects in boys without clear sex linkage. The conclusion is that the rate of consanguineous marriages was high, especially in the poorer areas, but the relationship between consanguineous marriages and birth defects was little or none. However, other child health indicators may be affected by consanguineous marriages.en_HK
dc.languageengen_HK
dc.relation.ispartofActa Paediatrica, International Journal of Paediatrics, Supplementen_HK
dc.subjectbirth defectsen_HK
dc.subjectinbreedingen_HK
dc.subjectPakistanen_HK
dc.subjecturbanizationen_HK
dc.titleEarly child health in Lahore, Pakistan: II. Inbreedingen_HK
dc.typeArticleen_HK
dc.identifier.emailKarlberg, J: jpekarl@hkucc.hku.hken_HK
dc.identifier.authorityKarlberg, J=rp00400en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8219463-
dc.identifier.scopuseid_2-s2.0-0027196163en_HK
dc.identifier.hkuros30223en_HK
dc.identifier.volume82en_HK
dc.identifier.issue390en_HK
dc.identifier.spage17en_HK
dc.identifier.epage26en_HK
dc.identifier.isiWOS:A1993MB05200003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYaqoob, M=55339406200en_HK
dc.identifier.scopusauthoridGustavson, KH=7103138225en_HK
dc.identifier.scopusauthoridJalil, F=7004018034en_HK
dc.identifier.scopusauthoridKarlberg, J=7005218406en_HK
dc.identifier.scopusauthoridIselius, L=7006971468en_HK

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