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Article: Bone marrow transplantation for hepatitis-associated aplastic anaemia: Case reports and a review of the literature

TitleBone marrow transplantation for hepatitis-associated aplastic anaemia: Case reports and a review of the literature
Authors
KeywordsAplastic anaemia
Bone marrow transplantation
Hepatitis
Issue Date2006
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Hong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 32-38 How to Cite?
AbstractHepatitis-associated aplastic anaemia is a rare cause of bone marrow aplasia. The exact aetiology and the pathogenetic mechanisms involved are largely unknown. The marrow aplasia is usually progressive and severe. Mortality is high without treatment. We report two cases of severe hepatitis-associated aplastic anaemia treated successfully with matched sibling allogeneic bone marrow transplantation, followed by a brief review of the major case series in the literature. Immunosuppressive conditioning regimen usually results in rapid resolution of hepatitis without concomitant liver injury. Bone marrow transplantation for the treatment of hepatitis-associated aplastic anaemia appears to result in good recovery of blood counts with favourable outcome similar to other causes of severe aplastic anaemia. Allogeneic bone marrow transplantation should be considered a preferred option for treatment of severe hepatitis-associated aplastic anaemia when a matched sibling donor is available.
Persistent Identifierhttp://hdl.handle.net/10722/80036
ISSN
2015 Impact Factor: 0.194
2015 SCImago Journal Rankings: 0.123
References

 

DC FieldValueLanguage
dc.contributor.authorCheuk, DKLen_HK
dc.contributor.authorLee, TLen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorChiang, AKSen_HK
dc.date.accessioned2010-09-06T08:01:38Z-
dc.date.available2010-09-06T08:01:38Z-
dc.date.issued2006en_HK
dc.identifier.citationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 32-38en_HK
dc.identifier.issn1013-9923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80036-
dc.description.abstractHepatitis-associated aplastic anaemia is a rare cause of bone marrow aplasia. The exact aetiology and the pathogenetic mechanisms involved are largely unknown. The marrow aplasia is usually progressive and severe. Mortality is high without treatment. We report two cases of severe hepatitis-associated aplastic anaemia treated successfully with matched sibling allogeneic bone marrow transplantation, followed by a brief review of the major case series in the literature. Immunosuppressive conditioning regimen usually results in rapid resolution of hepatitis without concomitant liver injury. Bone marrow transplantation for the treatment of hepatitis-associated aplastic anaemia appears to result in good recovery of blood counts with favourable outcome similar to other causes of severe aplastic anaemia. Allogeneic bone marrow transplantation should be considered a preferred option for treatment of severe hepatitis-associated aplastic anaemia when a matched sibling donor is available.en_HK
dc.languageengen_HK
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.aspen_HK
dc.relation.ispartofHong Kong Journal of Paediatricsen_HK
dc.subjectAplastic anaemiaen_HK
dc.subjectBone marrow transplantationen_HK
dc.subjectHepatitisen_HK
dc.titleBone marrow transplantation for hepatitis-associated aplastic anaemia: Case reports and a review of the literatureen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9923&volume=11&spage=32&epage=38&date=2006&atitle=Bone+Marrow+Transplantation+for+Hepatitis-associated+Aplastic+Anaemia:+Case+Reports+and+a+Review+of+the+Literatureen_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.emailChiang, AKS:chiangak@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityChiang, AKS=rp00403en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.scopuseid_2-s2.0-31344477268en_HK
dc.identifier.hkuros115024en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-31344477268&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue1en_HK
dc.identifier.spage32en_HK
dc.identifier.epage38en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridCheuk, DKL=8705936100en_HK
dc.identifier.scopusauthoridLee, TL=24483772800en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridChiang, AKS=7101623534en_HK

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