Article: Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia

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TitleFusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia
AuthorsMa, Z5
Morris, SW4 5
Valentine, V5
L, M7
Herbrick, JA7
Cui, X5
Bouman, D6
Li, Y7
Mehta, PK5
Nizetic, D1
Kaneko, Y3
Chan, GCF2
Chan, LC2
Squire, J6
Scherer, SW6 7
Hitzler, JK7
Issue Date2001
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
CitationNature Genetics, 2001, v. 28 n. 3, p. 220-221 [How to Cite?]
DOI: http://dx.doi.org/10.1038/90054
Abstractt(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.
ISSN1061-4036
2011 Impact Factor: 35.532
2011 SCImago Journal Rankings: 8.923
DOIhttp://dx.doi.org/10.1038/90054
ISI Accession Number IDWOS:000169656400013
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorMa, Z
dc.contributor.authorMorris, SW
dc.contributor.authorValentine, V
dc.contributor.authorL, M
dc.contributor.authorHerbrick, JA
dc.contributor.authorCui, X
dc.contributor.authorBouman, D
dc.contributor.authorLi, Y
dc.contributor.authorMehta, PK
dc.contributor.authorNizetic, D
dc.contributor.authorKaneko, Y
dc.contributor.authorChan, GCF
dc.contributor.authorChan, LC
dc.contributor.authorSquire, J
dc.contributor.authorScherer, SW
dc.contributor.authorHitzler, JK
dc.date.accessioned2010-09-06T08:01:36Z
dc.date.available2010-09-06T08:01:36Z
dc.date.issued2001
dc.description.abstractt(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationNature Genetics, 2001, v. 28 n. 3, p. 220-221 [How to Cite?]
DOI: http://dx.doi.org/10.1038/90054
dc.identifier.doihttp://dx.doi.org/10.1038/90054
dc.identifier.epage221
dc.identifier.hkuros67655
dc.identifier.isiWOS:000169656400013
dc.identifier.issn1061-4036
2011 Impact Factor: 35.532
2011 SCImago Journal Rankings: 8.923
dc.identifier.issue3
dc.identifier.openurl
dc.identifier.pmid11431691
dc.identifier.scopuseid_2-s2.0-0034941166
dc.identifier.spage220
dc.identifier.urihttp://hdl.handle.net/10722/80033
dc.identifier.volume28
dc.languageeng
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
dc.publisher.placeUnited States
dc.relation.ispartofNature Genetics
dc.relation.referencesReferences in Scopus
dc.subject.meshChromosomes, Human, Pair 1 - genetics
dc.subject.meshChromosomes, Human, Pair 22 - genetics
dc.subject.meshDNA-Binding Proteins - genetics
dc.subject.meshHumans
dc.subject.meshLeukemia, Megakaryoblastic, Acute - genetics
dc.subject.meshMolecular Sequence Data
dc.subject.meshOncogene Proteins, Fusion - genetics
dc.subject.meshRNA-Binding Proteins - genetics
dc.subject.meshTranslocation, Genetic
dc.titleFusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia
dc.typeArticle
Author Affiliations
  1. School of Pharmacy University of London
  2. The University of Hong Kong
  3. Saitama Cancer Center
  4. University of Tennessee Health Science Center
  5. St. Jude Children Research Hospital
  6. University of Toronto
  7. Hospital for Sick Children, Toronto