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Article: Percentile ranges for serum IgG subclass concentrations in healthy Chinese children

TitlePercentile ranges for serum IgG subclass concentrations in healthy Chinese children
Authors
KeywordsChinese
IgG subclasses
percentile ranges
Issue Date1993
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEI
Citation
Clinical And Experimental Immunology, 1993, v. 91 n. 2, p. 337-341 How to Cite?
AbstractIn order to establish normal reference ranges of serum immunoglobulin G subclasses for different age groups in Chinese, we measured the four IgG subclasses by radial immunodiffusion using polyclonal antisera in 350 normal healthy subjects (148 males and 202 females) recruited from the community. There was no significant sex difference for all the four IgG subclasses. Using Box-Cox transformation, we constructed smooth age-dependent percentile curves for the four IgG subclasses. For the 50th percentile values, the plateaus for IgG1 to IgG4 are respectively 970 mg/dl at 13 years old, 481 mg/dl at 18, 48 mg/dl at 17 and 80 mg/dl at 13. Methodology, reagents, environmental and genetic factors might be responsible for the observed difference among the various reports. The IgG2 level in our Chinese population seemed to be higher than that in Caucasians, which might account for the very low incidence of invasive Haemophilus influenzae type b disease among the Chinese. Our IgG1 level also plateaued later andat a higher level than that in other studies.
Persistent Identifierhttp://hdl.handle.net/10722/80031
ISSN
2015 Impact Factor: 3.148
2015 SCImago Journal Rankings: 1.369
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, YLen_HK
dc.contributor.authorJones, BMen_HK
dc.contributor.authorNg, KWen_HK
dc.contributor.authorYeung, CYen_HK
dc.date.accessioned2010-09-06T08:01:34Z-
dc.date.available2010-09-06T08:01:34Z-
dc.date.issued1993en_HK
dc.identifier.citationClinical And Experimental Immunology, 1993, v. 91 n. 2, p. 337-341en_HK
dc.identifier.issn0009-9104en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80031-
dc.description.abstractIn order to establish normal reference ranges of serum immunoglobulin G subclasses for different age groups in Chinese, we measured the four IgG subclasses by radial immunodiffusion using polyclonal antisera in 350 normal healthy subjects (148 males and 202 females) recruited from the community. There was no significant sex difference for all the four IgG subclasses. Using Box-Cox transformation, we constructed smooth age-dependent percentile curves for the four IgG subclasses. For the 50th percentile values, the plateaus for IgG1 to IgG4 are respectively 970 mg/dl at 13 years old, 481 mg/dl at 18, 48 mg/dl at 17 and 80 mg/dl at 13. Methodology, reagents, environmental and genetic factors might be responsible for the observed difference among the various reports. The IgG2 level in our Chinese population seemed to be higher than that in Caucasians, which might account for the very low incidence of invasive Haemophilus influenzae type b disease among the Chinese. Our IgG1 level also plateaued later andat a higher level than that in other studies.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEIen_HK
dc.relation.ispartofClinical and Experimental Immunologyen_HK
dc.rightsClinical and Experimental Immunology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectChineseen_HK
dc.subjectIgG subclassesen_HK
dc.subjectpercentile rangesen_HK
dc.titlePercentile ranges for serum IgG subclass concentrations in healthy Chinese childrenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0009-9104&volume=91&spage=337&epage=341&date=1993&atitle=Percentile+ranges+for+serum+IgG+subclass+concentrations+in+healthy+Chinese+childrenen_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8428400-
dc.identifier.scopuseid_2-s2.0-0027474402en_HK
dc.identifier.hkuros30217en_HK
dc.identifier.volume91en_HK
dc.identifier.issue2en_HK
dc.identifier.spage337en_HK
dc.identifier.epage341en_HK
dc.identifier.isiWOS:A1993KJ15700026-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridJones, BM=7404958958en_HK
dc.identifier.scopusauthoridNg, KW=37062713700en_HK
dc.identifier.scopusauthoridYeung, CY=7201354144en_HK

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