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Article: Recurrent major infections in juvenile-onset systemic lupus erythematosus - A close link with long-term disease damage

TitleRecurrent major infections in juvenile-onset systemic lupus erythematosus - A close link with long-term disease damage
Authors
KeywordsChildren
Infections
SLE
SlE Damage Index
Issue Date2007
PublisherOxford University Press. The Journal's web site is located at http://rheumatology.oxfordjournals.org/
Citation
Rheumatology, 2007, v. 46 n. 8, p. 1290-1296 How to Cite?
AbstractObjectives. We postulate that patients with systemic lupus erythematosus (SLE) having recurrent infections are more likely to have poorer disease outcome. The aim of this study is to describe the pattern of infections and disease damage that occurred in a cohort of patients with juvenile-onset SLE, and to find out whether cumulative disease damage was associated with recurrent infections in these patients. Method. We retrospectively reviewed (1988-2004) the clinical characteristics, infective complications, and disease damage as measured by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (SDI) in 47 juvenile-onset SLE patients. Potential risk factors for disease damage were evaluated by univariate analysis and logistic regression. The correlation between number of major infections and disease damage was determined. Results. Thirty-two (68.1%) patients had lupus nephropathy and 16 patients (34%) had neuropsychiatric lupus. Sixty-one episodes of major infections, defined as infections requiring more than 1 week of antimicrobial agents, occurred in 27 patients (57.4%), and 18 patients (31.4%) had recurrent major infections (≥ 2 episodes). Organ damage (SDI ≥ 1) was documented in 21 subjects (44.7%). By logistic regression, occurrence of major infections (P lt; 0.001) was the only significant risk factor for disease damage. There was a positive correlation between SDI score with the number of recurrent major infections (Spearman's correlation coefficient = 0.50, P lt; 0.001). Conclusion. Infections and disease damage are common co-morbidities in juvenile-onset SLE. Recurrent infections could predict poorer disease outcome and associated organ damage in SLE. © The Author 2007.
Persistent Identifierhttp://hdl.handle.net/10722/80023
ISSN
2015 Impact Factor: 4.524
2015 SCImago Journal Rankings: 1.449
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, PPWen_HK
dc.contributor.authorLee, TLen_HK
dc.contributor.authorHo, MHKen_HK
dc.contributor.authorWong, WHSen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-06T08:01:29Z-
dc.date.available2010-09-06T08:01:29Z-
dc.date.issued2007en_HK
dc.identifier.citationRheumatology, 2007, v. 46 n. 8, p. 1290-1296en_HK
dc.identifier.issn1462-0324en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80023-
dc.description.abstractObjectives. We postulate that patients with systemic lupus erythematosus (SLE) having recurrent infections are more likely to have poorer disease outcome. The aim of this study is to describe the pattern of infections and disease damage that occurred in a cohort of patients with juvenile-onset SLE, and to find out whether cumulative disease damage was associated with recurrent infections in these patients. Method. We retrospectively reviewed (1988-2004) the clinical characteristics, infective complications, and disease damage as measured by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (SDI) in 47 juvenile-onset SLE patients. Potential risk factors for disease damage were evaluated by univariate analysis and logistic regression. The correlation between number of major infections and disease damage was determined. Results. Thirty-two (68.1%) patients had lupus nephropathy and 16 patients (34%) had neuropsychiatric lupus. Sixty-one episodes of major infections, defined as infections requiring more than 1 week of antimicrobial agents, occurred in 27 patients (57.4%), and 18 patients (31.4%) had recurrent major infections (≥ 2 episodes). Organ damage (SDI ≥ 1) was documented in 21 subjects (44.7%). By logistic regression, occurrence of major infections (P lt; 0.001) was the only significant risk factor for disease damage. There was a positive correlation between SDI score with the number of recurrent major infections (Spearman's correlation coefficient = 0.50, P lt; 0.001). Conclusion. Infections and disease damage are common co-morbidities in juvenile-onset SLE. Recurrent infections could predict poorer disease outcome and associated organ damage in SLE. © The Author 2007.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://rheumatology.oxfordjournals.org/en_HK
dc.relation.ispartofRheumatologyen_HK
dc.rightsRheumatology. Copyright © S Karger AG.en_HK
dc.subjectChildrenen_HK
dc.subjectInfectionsen_HK
dc.subjectSLEen_HK
dc.subjectSlE Damage Indexen_HK
dc.titleRecurrent major infections in juvenile-onset systemic lupus erythematosus - A close link with long-term disease damageen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0080-2727&volume=46&issue=8&spage=1290&epage=1296&date=2007&atitle=Recurrent+major+infections+in+juvenile-onset+systemic+Lupus+erythematosus+-+a+close+link+with+long-term+disease+damageen_HK
dc.identifier.emailLee, PPW:ppwlee@hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityLee, PPW=rp00462en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/rheumatology/kem102en_HK
dc.identifier.pmid17522097-
dc.identifier.scopuseid_2-s2.0-34547830793en_HK
dc.identifier.hkuros128420en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547830793&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume46en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1290en_HK
dc.identifier.epage1296en_HK
dc.identifier.isiWOS:000248686800015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLee, PPW=14048822200en_HK
dc.identifier.scopusauthoridLee, TL=24483772800en_HK
dc.identifier.scopusauthoridHo, MHK=8925896400en_HK
dc.identifier.scopusauthoridWong, WHS=13310222200en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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