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Article: Serum mannose-binding lectin levels and mbl2 gene polymorphisms in different age and gender groups of southern Chinese adults

TitleSerum mannose-binding lectin levels and mbl2 gene polymorphisms in different age and gender groups of southern Chinese adults
Authors
Issue Date2004
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/SJI
Citation
Scandinavian Journal Of Immunology, 2004, v. 59 n. 3, p. 310-314 How to Cite?
AbstractMannose-binding lectin (MBL) is an acute-phase serum protein, and its inherited deficiency has been shown to predispose to infections. The developmental profile of serum MBL in preterm infants has been demonstrated previously. To determine the profiles of serum MBL levels and mbl2 polymorphisms over age and genders in an adult population, samples from 689 southern Chinese (age range 16-57 years; 382 males and 307 females) were studied using enzyme-linked immunosorbent assay and high-throughput genotyping of mbl2. Serum MBL levels maintained within a narrow range from age groups of 16-20 years old to 31-40 years old (mean of 2050-2160 μg/l) and declined to a mean of 1466 μg/l in the last age group 41-57 years old. No significant differences were found in the distributions of mbl2 haplotypes (YA, XA and YB) among all these age groups. Between gender groups, no significant imbalance of MBL profile in terms of serum MBL levels and distribution of mbl2 haplotypes was found. Results suggest an important role of circulating MBL in first-line host defence because MBL maintains at fairly constant levels after childhood and no gender influence on the MBL profile.
Persistent Identifierhttp://hdl.handle.net/10722/80020
ISSN
2015 Impact Factor: 2.27
2015 SCImago Journal Rankings: 0.934
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorIp, WKen_HK
dc.contributor.authorTo, YFen_HK
dc.contributor.authorCheng, SKen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-06T08:01:26Z-
dc.date.available2010-09-06T08:01:26Z-
dc.date.issued2004en_HK
dc.identifier.citationScandinavian Journal Of Immunology, 2004, v. 59 n. 3, p. 310-314en_HK
dc.identifier.issn0300-9475en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80020-
dc.description.abstractMannose-binding lectin (MBL) is an acute-phase serum protein, and its inherited deficiency has been shown to predispose to infections. The developmental profile of serum MBL in preterm infants has been demonstrated previously. To determine the profiles of serum MBL levels and mbl2 polymorphisms over age and genders in an adult population, samples from 689 southern Chinese (age range 16-57 years; 382 males and 307 females) were studied using enzyme-linked immunosorbent assay and high-throughput genotyping of mbl2. Serum MBL levels maintained within a narrow range from age groups of 16-20 years old to 31-40 years old (mean of 2050-2160 μg/l) and declined to a mean of 1466 μg/l in the last age group 41-57 years old. No significant differences were found in the distributions of mbl2 haplotypes (YA, XA and YB) among all these age groups. Between gender groups, no significant imbalance of MBL profile in terms of serum MBL levels and distribution of mbl2 haplotypes was found. Results suggest an important role of circulating MBL in first-line host defence because MBL maintains at fairly constant levels after childhood and no gender influence on the MBL profile.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/SJIen_HK
dc.relation.ispartofScandinavian Journal of Immunologyen_HK
dc.rightsScandinavian Journal of Immunology. Copyright © Blackwell Publishing Ltd.en_HK
dc.titleSerum mannose-binding lectin levels and mbl2 gene polymorphisms in different age and gender groups of southern Chinese adultsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-9475&volume=59&spage=310&epage=314&date=2004&atitle=Serum+Mannose-Binding+Lectin+Levels+and+mbl2+Gene+Polymorphisms+in+Different+Age+and+Gender+Groups+of+Southern+Chinese+Adultsen_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.0300-9475.2004.01392.xen_HK
dc.identifier.pmid15030583-
dc.identifier.scopuseid_2-s2.0-1842505122en_HK
dc.identifier.hkuros85828en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1842505122&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume59en_HK
dc.identifier.issue3en_HK
dc.identifier.spage310en_HK
dc.identifier.epage314en_HK
dc.identifier.isiWOS:000220356300011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridIp, WK=35083568800en_HK
dc.identifier.scopusauthoridTo, YF=11641177600en_HK
dc.identifier.scopusauthoridCheng, SK=7404685125en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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