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Article: Different allelic frequencies of several cytokine genes in Hong Kong Chinese and Swedish Caucasians

TitleDifferent allelic frequencies of several cytokine genes in Hong Kong Chinese and Swedish Caucasians
Authors
KeywordsGene polymorphism
IL10
TGFB1
TNFA
TNFR1
Issue Date2001
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/gene
Citation
Genes And Immunity, 2001, v. 2 n. 5, p. 280-283 How to Cite?
AbstractIt has been shown that cytokine gene polymorphisms are important in the regulation of the level of cytokine production that may affect the development and extent of inflammatory diseases and transplant rejections. The frequency of the -308 TNFA, -383 TNFR1, -1087 IL10 and codon 25 TGFB1 alleles were analysed in two different ethnic groups: Chinese from Hong Kong and Caucasians from western Sweden. Significant differences in the occurrence of the analysed alleles were shown between the two populations. The most profound difference was found in the frequency of the A/A genotype at the -1087 position of IL10 gene (18% in Caucasians and 89% in Chinese, P < 0.0001, both for the genotype and allele frequencies) and less although statistically significant for other investigated genes. The noted differences in the frequency of functionally important alleles of cytokine genes may have consequences for the mode of appearance and outcome of certain diseases in individuals of different ethnicity.
Persistent Identifierhttp://hdl.handle.net/10722/80005
ISSN
2015 Impact Factor: 2.472
2015 SCImago Journal Rankings: 1.636
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPadyukov, Len_HK
dc.contributor.authorHahnZoric, Men_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorHanson, LÅen_HK
dc.date.accessioned2010-09-06T08:01:16Z-
dc.date.available2010-09-06T08:01:16Z-
dc.date.issued2001en_HK
dc.identifier.citationGenes And Immunity, 2001, v. 2 n. 5, p. 280-283en_HK
dc.identifier.issn1466-4879en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80005-
dc.description.abstractIt has been shown that cytokine gene polymorphisms are important in the regulation of the level of cytokine production that may affect the development and extent of inflammatory diseases and transplant rejections. The frequency of the -308 TNFA, -383 TNFR1, -1087 IL10 and codon 25 TGFB1 alleles were analysed in two different ethnic groups: Chinese from Hong Kong and Caucasians from western Sweden. Significant differences in the occurrence of the analysed alleles were shown between the two populations. The most profound difference was found in the frequency of the A/A genotype at the -1087 position of IL10 gene (18% in Caucasians and 89% in Chinese, P < 0.0001, both for the genotype and allele frequencies) and less although statistically significant for other investigated genes. The noted differences in the frequency of functionally important alleles of cytokine genes may have consequences for the mode of appearance and outcome of certain diseases in individuals of different ethnicity.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/geneen_HK
dc.relation.ispartofGenes and Immunityen_HK
dc.subjectGene polymorphismen_HK
dc.subjectIL10en_HK
dc.subjectTGFB1en_HK
dc.subjectTNFAen_HK
dc.subjectTNFR1en_HK
dc.titleDifferent allelic frequencies of several cytokine genes in Hong Kong Chinese and Swedish Caucasiansen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1466-4879&volume=2&spage=280&epage=283&date=2001&atitle=Different+allelic+frequencies+of+several+cytokine+genes+in+Hong+Kong+Chinese+and+Swedish+Caucasiansen_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj.gene.6363771en_HK
dc.identifier.pmid11528523-
dc.identifier.scopuseid_2-s2.0-0035433214en_HK
dc.identifier.hkuros65008en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035433214&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2en_HK
dc.identifier.issue5en_HK
dc.identifier.spage280en_HK
dc.identifier.epage283en_HK
dc.identifier.isiWOS:000170607300009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPadyukov, L=6603725900en_HK
dc.identifier.scopusauthoridHahnZoric, M=7003445850en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridHanson, LÅ=7201657486en_HK

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