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Article: Complex cytogenetic abnormalities in T-lymphoblastic lymphoma: Resolution by spectral karyotyping

TitleComplex cytogenetic abnormalities in T-lymphoblastic lymphoma: Resolution by spectral karyotyping
Authors
Issue Date2000
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2000, v. 118 n. 1, p. 24-27 How to Cite?
AbstractWe describe a case of T-lymphoblastic lymphoma (T-LBL) in a 13-year-old boy in which conventional cytogenetic analysis of lymph node tissue showed complex karyotypic aberrations including add(1p), add(2q), and multiple chromosomal deletions involving 5q, 7p, 7q, 13q, and 16q. Analysis by spectral karyotyping (SKY) refined add(1p) to a paracentric inversion of 1p, and add(2q) to an unbalanced translocation between chromosomes 2 and 4. The chromosomal deletions were simple deletions except del(5q), which was confirmed by SKY to be a cryptic unbalanced translocation between chromosomes 5 and 18. The present report illustrates that SKY technology is useful in identifying subtle translocations and resolving complex karyotypic aberrations in neoplastic disorders. Copyright (C) 2000 Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/80002
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWan, TSKen_HK
dc.contributor.authorMa, SKen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorChing, LMen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorChan, LCen_HK
dc.date.accessioned2010-09-06T08:01:14Z-
dc.date.available2010-09-06T08:01:14Z-
dc.date.issued2000en_HK
dc.identifier.citationCancer Genetics And Cytogenetics, 2000, v. 118 n. 1, p. 24-27en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/80002-
dc.description.abstractWe describe a case of T-lymphoblastic lymphoma (T-LBL) in a 13-year-old boy in which conventional cytogenetic analysis of lymph node tissue showed complex karyotypic aberrations including add(1p), add(2q), and multiple chromosomal deletions involving 5q, 7p, 7q, 13q, and 16q. Analysis by spectral karyotyping (SKY) refined add(1p) to a paracentric inversion of 1p, and add(2q) to an unbalanced translocation between chromosomes 2 and 4. The chromosomal deletions were simple deletions except del(5q), which was confirmed by SKY to be a cryptic unbalanced translocation between chromosomes 5 and 18. The present report illustrates that SKY technology is useful in identifying subtle translocations and resolving complex karyotypic aberrations in neoplastic disorders. Copyright (C) 2000 Elsevier Science Inc.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.en_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshChromosome Aberrations - geneticsen_HK
dc.subject.meshChromosome Bandingen_HK
dc.subject.meshChromosome Deletionen_HK
dc.subject.meshChromosome Inversionen_HK
dc.subject.meshColoren_HK
dc.subject.meshCytogenetic Analysisen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKaryotypingen_HK
dc.subject.meshMaleen_HK
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma - genetics - pathologyen_HK
dc.subject.meshTranslocation, Geneticen_HK
dc.titleComplex cytogenetic abnormalities in T-lymphoblastic lymphoma: Resolution by spectral karyotypingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0165-4608&volume=118&spage=24&epage=27&date=2000&atitle=Complex+cytogenetic+abnormalities+in+t-lymphoblastic+lymphoma:+resolution+by+spectral+karyotypingen_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0165-4608(99)00174-0en_HK
dc.identifier.pmid10731586-
dc.identifier.scopuseid_2-s2.0-0034175958en_HK
dc.identifier.hkuros48885en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034175958&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume118en_HK
dc.identifier.issue1en_HK
dc.identifier.spage24en_HK
dc.identifier.epage27en_HK
dc.identifier.isiWOS:000086124000005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWan, TSK=25623981600en_HK
dc.identifier.scopusauthoridMa, SK=9042504200en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridChing, LM=24293081200en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK

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