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Article: Risk factors and treatment of hemorrhagic cystitis in children who underwent hematopoietic stem cell transplantation

TitleRisk factors and treatment of hemorrhagic cystitis in children who underwent hematopoietic stem cell transplantation
Authors
KeywordsChildren
Formalin
Hematopoietic stem cell transplantation
Hemorrhagic cystitis
Issue Date2006
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0934-0874&site=1
Citation
Transplant International, 2006, v. 20 n. 1, p. 73-81 How to Cite?
AbstractA retrospective cohort of 163 children with 171 hematopoietic stem cell transplantation (HSCT) performed during Mar. 1992-Dec. 2005 were analyzed to evaluate the incidence, risk factors, management, and outcome of hemorrhagic cystitis (HC). Fourteen patients (8.2%) developed HC (6 boys, median age 6.6 years) at 0-166 days after HSCT (median 25 days), and lasted for 3-96 days (median 26 days). Older age at transplant (median 11.0 vs. 6.4 years, P = 0.013), allogeneic transplant (OR = 4.4, P = 0.02), cyclophosphamide-containing conditioning (OR = 4.87, P = 0.008), moderate-to-severe acute graft-versus-host disease (GVHD) (OR = 3.56, P = 0.025) and hepatic GVHD (OR = 3.62, P = 0.017) were associated with higher risks of HC in univariate but not multivariate analyses. While estrogen was ineffective in most patients, intravesical formalin, which was used in five patients, was found to be a very effective yet safe treatment for intractable HC. Patients with HC had longer hospital stay (median 175 vs. 88 days, P = 0.004). HC resolved after treatments in all cases but eight of the 14 patients subsequently died of other complications of HSCT. In conclusion, HC is a serious complication of allogeneic HSCT. Treatment with intravesical formalin appears effective and safe and can be considered early in severe HC to reduce the risk of morbidity and mortality. © 2006 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/79990
ISSN
2015 Impact Factor: 2.835
2015 SCImago Journal Rankings: 1.107
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheuk, DKLen_HK
dc.contributor.authorLee, TLen_HK
dc.contributor.authorChiang, AKSen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorChan, GCFen_HK
dc.date.accessioned2010-09-06T08:01:06Z-
dc.date.available2010-09-06T08:01:06Z-
dc.date.issued2006en_HK
dc.identifier.citationTransplant International, 2006, v. 20 n. 1, p. 73-81en_HK
dc.identifier.issn0934-0874en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79990-
dc.description.abstractA retrospective cohort of 163 children with 171 hematopoietic stem cell transplantation (HSCT) performed during Mar. 1992-Dec. 2005 were analyzed to evaluate the incidence, risk factors, management, and outcome of hemorrhagic cystitis (HC). Fourteen patients (8.2%) developed HC (6 boys, median age 6.6 years) at 0-166 days after HSCT (median 25 days), and lasted for 3-96 days (median 26 days). Older age at transplant (median 11.0 vs. 6.4 years, P = 0.013), allogeneic transplant (OR = 4.4, P = 0.02), cyclophosphamide-containing conditioning (OR = 4.87, P = 0.008), moderate-to-severe acute graft-versus-host disease (GVHD) (OR = 3.56, P = 0.025) and hepatic GVHD (OR = 3.62, P = 0.017) were associated with higher risks of HC in univariate but not multivariate analyses. While estrogen was ineffective in most patients, intravesical formalin, which was used in five patients, was found to be a very effective yet safe treatment for intractable HC. Patients with HC had longer hospital stay (median 175 vs. 88 days, P = 0.004). HC resolved after treatments in all cases but eight of the 14 patients subsequently died of other complications of HSCT. In conclusion, HC is a serious complication of allogeneic HSCT. Treatment with intravesical formalin appears effective and safe and can be considered early in severe HC to reduce the risk of morbidity and mortality. © 2006 The Authors.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0934-0874&site=1en_HK
dc.relation.ispartofTransplant Internationalen_HK
dc.rightsTransplant International. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectChildrenen_HK
dc.subjectFormalinen_HK
dc.subjectHematopoietic stem cell transplantationen_HK
dc.subjectHemorrhagic cystitisen_HK
dc.titleRisk factors and treatment of hemorrhagic cystitis in children who underwent hematopoietic stem cell transplantationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0934-0874&volume=20&spage=73&epage=81&date=2007&atitle=Risk+factors+and+treatment+of+hemorrhagic+cystitis+in+children+who+underwent+hematopoietic+stem+cell+transplantationen_HK
dc.identifier.emailChiang, AKS:chiangak@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityChiang, AKS=rp00403en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1432-2277.2006.00404.xen_HK
dc.identifier.pmid17181656-
dc.identifier.scopuseid_2-s2.0-33845616344en_HK
dc.identifier.hkuros126105en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845616344&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue1en_HK
dc.identifier.spage73en_HK
dc.identifier.epage81en_HK
dc.identifier.isiWOS:000242871100011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheuk, DKL=8705936100en_HK
dc.identifier.scopusauthoridLee, TL=8508917400en_HK
dc.identifier.scopusauthoridChiang, AKS=7101623534en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.citeulike996465-

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