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Article: Haemophilia B: Should we stop using prothrombin complex concentrates in Hong Kong?

TitleHaemophilia B: Should we stop using prothrombin complex concentrates in Hong Kong?
Authors
KeywordsCoagulation factor concentrate
Haemophilia B
Prothrombin complex concentrate
Thromboembolism
Issue Date2006
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Hong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 50-54 How to Cite?
AbstractThe use of coagulation factor concentrates remains the mainstay treatment for haemophilias. Prothrombin complex concentrates, plasma-derived products that contain other vitamin K-dependent factors additional to factor IX, have been used for treatment of haemophilia B since 1959. However, they carry a small but significant risk of thromboembolic complications, and fatalities subsequent to myocardial infarction have been reported. We recommend that highly purified plasma-derived or recombinant products of factor IX concentrates should be the treatment of choice for patients with haemophilia B, especially those who are at higher risk for thromboembolism.
Persistent Identifierhttp://hdl.handle.net/10722/79981
ISSN
2015 Impact Factor: 0.194
2015 SCImago Journal Rankings: 0.123
References

 

DC FieldValueLanguage
dc.contributor.authorLee, ACWen_HK
dc.contributor.authorShing, MMKen_HK
dc.contributor.authorLing, SCen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorYuen, HLen_HK
dc.date.accessioned2010-09-06T08:01:00Z-
dc.date.available2010-09-06T08:01:00Z-
dc.date.issued2006en_HK
dc.identifier.citationHong Kong Journal Of Paediatrics, 2006, v. 11 n. 1, p. 50-54en_HK
dc.identifier.issn1013-9923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79981-
dc.description.abstractThe use of coagulation factor concentrates remains the mainstay treatment for haemophilias. Prothrombin complex concentrates, plasma-derived products that contain other vitamin K-dependent factors additional to factor IX, have been used for treatment of haemophilia B since 1959. However, they carry a small but significant risk of thromboembolic complications, and fatalities subsequent to myocardial infarction have been reported. We recommend that highly purified plasma-derived or recombinant products of factor IX concentrates should be the treatment of choice for patients with haemophilia B, especially those who are at higher risk for thromboembolism.en_HK
dc.languageengen_HK
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.aspen_HK
dc.relation.ispartofHong Kong Journal of Paediatricsen_HK
dc.subjectCoagulation factor concentrateen_HK
dc.subjectHaemophilia Ben_HK
dc.subjectProthrombin complex concentrateen_HK
dc.subjectThromboembolismen_HK
dc.titleHaemophilia B: Should we stop using prothrombin complex concentrates in Hong Kong?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9923&volume=11&spage=50&epage=54&date=2006&atitle=Haemophilia+B:+Should+We+Stop+Using+Prothrombin+Complex+Concentrates+in+Hong+Kong?en_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-31344442220en_HK
dc.identifier.hkuros114551en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-31344442220&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue1en_HK
dc.identifier.spage50en_HK
dc.identifier.epage54en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridLee, ACW=7405631431en_HK
dc.identifier.scopusauthoridShing, MMK=7006423846en_HK
dc.identifier.scopusauthoridLing, SC=7102701299en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridYuen, HL=7103253677en_HK

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