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Article: Combined factor V and factor VIII deficiency in a girl with haemarthrosis

TitleCombined factor V and factor VIII deficiency in a girl with haemarthrosis
Authors
KeywordsClotting proteins
Factor V deficiency
Factor VIII deficiency
Haemarthrosis
Haemophilia
Issue Date1996
PublisherMedcom Limited.
Citation
Hong Kong Journal of Paediatrics, 1996, v. 1 n. 1, p. 70-73 How to Cite?
AbstractFactor VIII and factor V are clotting proteins acting as cofactors respectively for factor IX in the intrinsic pathway and factor X in the common pathway of the coagulation cascade. Haemophilia A due to factor VIII deficiency is transmitted as an X-linked disease occurring in 1 in 10,000 males. Factor V deficiency alone is rare and is autosomal recessive with an estimated incidence of 1 in a million persons. Combined factor V and factor VIII deficiency is also rare but is the commonest of the inherited deficiencies of more than one coagulation factors. We describe a 5 year old Chinese girl who presented with haemarthrosis and diagnosed to have combined factor V and VIII deficiencies. She was found to have prolonged activated partial thromboplastin time and prolonged prothrombin time. Factor assays showed low factor V level of 0.14 u/ml and low factor VIII level of 0.20 u/ml. Her symptoms subsided with infusion of fresh frozen plasma. Over a 2 year follow up period, she has been free from further major bleeding.
Persistent Identifierhttp://hdl.handle.net/10722/79978
ISSN
2015 Impact Factor: 0.194
2015 SCImago Journal Rankings: 0.123

 

DC FieldValueLanguage
dc.contributor.authorWei, DCCen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-06T08:00:58Z-
dc.date.available2010-09-06T08:00:58Z-
dc.date.issued1996en_HK
dc.identifier.citationHong Kong Journal of Paediatrics, 1996, v. 1 n. 1, p. 70-73en_HK
dc.identifier.issn1013-9923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/79978-
dc.description.abstractFactor VIII and factor V are clotting proteins acting as cofactors respectively for factor IX in the intrinsic pathway and factor X in the common pathway of the coagulation cascade. Haemophilia A due to factor VIII deficiency is transmitted as an X-linked disease occurring in 1 in 10,000 males. Factor V deficiency alone is rare and is autosomal recessive with an estimated incidence of 1 in a million persons. Combined factor V and factor VIII deficiency is also rare but is the commonest of the inherited deficiencies of more than one coagulation factors. We describe a 5 year old Chinese girl who presented with haemarthrosis and diagnosed to have combined factor V and VIII deficiencies. She was found to have prolonged activated partial thromboplastin time and prolonged prothrombin time. Factor assays showed low factor V level of 0.14 u/ml and low factor VIII level of 0.20 u/ml. Her symptoms subsided with infusion of fresh frozen plasma. Over a 2 year follow up period, she has been free from further major bleeding.-
dc.languageengen_HK
dc.publisherMedcom Limited.en_HK
dc.relation.ispartofHong Kong Journal of Paediatricsen_HK
dc.subjectClotting proteins-
dc.subjectFactor V deficiency-
dc.subjectFactor VIII deficiency-
dc.subjectHaemarthrosis-
dc.subjectHaemophilia-
dc.titleCombined factor V and factor VIII deficiency in a girl with haemarthrosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9923&volume=1&issue=1&spage=70&epage=73&date=1996&atitle=Combined+factor+V+and+factor+VIII+deficiency+in+a+girl+with+haemarthrosisen_HK
dc.identifier.emailHa, SY: syha@hkucc.hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hkucc.hku.hken_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros14096en_HK

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